[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100394987":3},{"organization":4,"armGroups":7,"interventions":44,"overallOfficials":257,"centralContacts":224,"locations":262,"responsibleParty":4132,"collaborators":4134,"id":4138,"slug":4139,"hasResults":4140,"nctId":4141,"briefTitle":4142,"officialTitle":4143,"acronym":224,"eligibilityCriteria":4144,"healthyVolunteers":4140,"sex":4145,"minAge":4146,"maxAge":224,"enrollmentInfo":4147,"targetDuration":224,"studyType":4150,"phases":4151,"briefSummary":4153,"conditions":4154,"keywords":224,"overallStatus":265,"whyStopped":224,"lastUpdateSubmitDate":4159,"lastUpdatePostDateStruct":4160,"startDateStruct":4163,"completionDateStruct":4165,"leadSponsor":4167,"locationsCount":4168},{"fullName":5,"class":6},"Eastern Cooperative Oncology Group","NETWORK",[8,25,31,35],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A (EBRT, short-term androgen deprivation therapy [STAD])","ACTIVE_COMPARATOR","STEP 0: Patients undergo SOC PET\u002FCT or PET\u002FMR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.\n\nSTEP 1: Patients who are PET negative for extera pelvic metastases undergo SOC EBRT for 6 months. Patients also receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC for 6 months starting up to 3 months prior to EBRT but no later than 7 days after start of EBRT. All treatment continues for 6 months in the absence of disease progression or unacceptable toxicity.",[13,14,15,16,17,18,19,20,21,22,23,24],"Procedure: Computed Tomography","Drug: Degarelix","Radiation: External Beam Radiation Therapy","Other: Fluciclovine F18","Drug: Goserelin Acetate","Drug: Leuprolide Acetate","Procedure: Magnetic Resonance Imaging","Procedure: Positron Emission Tomography","Other: Quality-of-Life Assessment","Other: Questionnaire Administration","Drug: Relugolix","Drug: Triptorelin",{"label":26,"type":27,"description":28,"interventionNames":29},"Arm B (EBRT, STAD, apalutamide)","EXPERIMENTAL","STEP 0: Patients undergo SOC PET\u002FCT or PET\u002FMR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.\n\nSTEP 1: Patients who are PET negative for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD for 6 months in the absence of disease progression or unacceptable toxicity.",[30,13,14,15,16,17,18,19,20,21,22,23,24],"Drug: Apalutamide",{"label":32,"type":27,"description":33,"interventionNames":34},"Arm C (EBRT, STAD, apalutamide)","STEP 0: Patients undergo SOC PET\u002FCT or PET\u002FMR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.\n\nSTEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A. Patients also receive apalutamide PO QD as in Arm B.",[30,13,14,15,16,17,18,19,20,21,22,23,24],{"label":36,"type":27,"description":37,"interventionNames":38},"Arm D (EBRT, STAD, apalutamide, RT)","STEP 0: Patients undergo SOC PET\u002FCT or PET\u002FMR scan at baseline. Patients randomized to Arms C or D and receiving fluciclovine F18 IV undergo a repeat PET2 at time of PSA progression or clinical concerns for progression or 12 months after completion of enhanced systemic therapy, whichever occurs first. Patients in Arm C or D using another tracer for PET1 do not undergo PET2.\n\nSTEP 1: Patients who are PET positive for extra pelvic metastases undergo SOC EBRT and receive goserelin acetate SC, leuprolide acetate IM, triptorelin IM, relugolix PO, or degarelix SC as in Arm A and apalutamide PO QD as in Arm B. Patients also undergo SBRT or 3D CRT, IMRT (including VMAT), and IMPT over 3-10 fractions in the absence of disease progression or unacceptable toxicity.",[39,30,13,14,15,16,17,40,41,18,19,20,21,22,23,42,24,43],"Radiation: 3-Dimensional Conformal Radiation Therapy","Procedure: Intensity-Modulated Proton Therapy","Radiation: Intensity-Modulated Radiation Therapy","Radiation: Stereotactic Body Radiation Therapy","Radiation: Volume Modulated Arc Therapy",[45,61,73,88,95,113,131,137,143,153,186,202,215,221,225,233,241,250],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":50},"RADIATION","3-Dimensional Conformal Radiation Therapy","Undergo 3D CRT",[36],[51,52,53,54,55,56,57,58,59,60],"3-dimensional radiation therapy","3D Conformal","3D CONFORMAL RADIATION THERAPY","3D CRT","3D radiotherapy","3D-CRT","Conformal Therapy","Radiation Conformal Therapy","Radiation, 3D Conformal","Three dimensional external beam radiation therapy 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Associates in Radiation Medicine","RECRUITING","Anchorage","Alaska","98508","United States","US",{"type":272,"coordinates":273},"Point",[274,275],-149.90028,61.21806,{"lat":275,"lon":274},[278,283],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},"Site Public Contact","CONTACT","907-212-6871","AKPAMC.OncologyResearchSupport@providence.org",{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},"Alison K. Conlin",{"facility":286,"status":265,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":288,"geoPoint":290,"contacts":291},"Alaska Breast Care and Surgery LLC","99508",{"type":272,"coordinates":289},[274,275],{"lat":275,"lon":274},[292,293],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":295,"status":265,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":296,"geoPoint":298,"contacts":299},"Alaska Oncology and Hematology LLC",{"type":272,"coordinates":297},[274,275],{"lat":275,"lon":274},[300,301],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":303,"status":265,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":304,"geoPoint":306,"contacts":307},"Alaska Women's Cancer Care",{"type":272,"coordinates":305},[274,275],{"lat":275,"lon":274},[308,309],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":311,"status":312,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":313,"geoPoint":315,"contacts":224},"Anchorage Oncology Centre","SUSPENDED",{"type":272,"coordinates":314},[274,275],{"lat":275,"lon":274},{"facility":317,"status":265,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":318,"geoPoint":320,"contacts":321},"Katmai Oncology Group",{"type":272,"coordinates":319},[274,275],{"lat":275,"lon":274},[322,323],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":325,"status":265,"city":266,"state":267,"zip":287,"country":269,"countryCode":270,"cosmosGeoPoint":326,"geoPoint":328,"contacts":329},"Providence Alaska Medical Center",{"type":272,"coordinates":327},[274,275],{"lat":275,"lon":274},[330,331],{"name":279,"role":280,"phone":281,"phoneExt":224,"email":282},{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":333,"status":312,"city":334,"state":267,"zip":335,"country":269,"countryCode":270,"cosmosGeoPoint":336,"geoPoint":340,"contacts":224},"Fairbanks Memorial Hospital","Fairbanks","99701",{"type":272,"coordinates":337},[338,339],-147.71639,64.83778,{"lat":339,"lon":338},{"facility":342,"status":265,"city":343,"state":344,"zip":345,"country":269,"countryCode":270,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Cancer Center at Saint Joseph's","Phoenix","Arizona","85004",{"type":272,"coordinates":347},[348,349],-112.07404,33.44838,{"lat":349,"lon":348},[352,355],{"name":279,"role":280,"phone":353,"phoneExt":224,"email":354},"720-874-1881","ResearchInstituteInquiries@CommonSpirit.org",{"name":356,"role":261,"phone":224,"phoneExt":224,"email":224},"Shahzad Siddique",{"facility":358,"status":265,"city":359,"state":360,"zip":361,"country":269,"countryCode":270,"cosmosGeoPoint":362,"geoPoint":366,"contacts":367},"Mercy Hospital Fort Smith","Fort Smith","Arkansas","72903",{"type":272,"coordinates":363},[364,365],-94.39855,35.38592,{"lat":365,"lon":364},[368,370],{"name":279,"role":280,"phone":369,"phoneExt":224,"email":224},"800-378-9373",{"name":371,"role":261,"phone":224,"phoneExt":224,"email":224},"Jay W. Carlson",{"facility":373,"status":265,"city":374,"state":375,"zip":376,"country":269,"countryCode":270,"cosmosGeoPoint":377,"geoPoint":381,"contacts":382},"Mission Hope Medical Oncology - Arroyo Grande","Arroyo Grande","California","93420",{"type":272,"coordinates":378},[379,380],-120.59073,35.11859,{"lat":380,"lon":379},[383,384],{"name":279,"role":280,"phone":353,"phoneExt":224,"email":354},{"name":356,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":386,"status":265,"city":387,"state":375,"zip":388,"country":269,"countryCode":270,"cosmosGeoPoint":389,"geoPoint":393,"contacts":394},"Providence Saint Joseph Medical Center\u002FDisney Family Cancer Center","Burbank","91505",{"type":272,"coordinates":390},[391,392],-118.30897,34.18084,{"lat":392,"lon":391},[395,398],{"name":279,"role":280,"phone":396,"phoneExt":224,"email":397},"818-847-4793","Najee.Boucher@providence.org",{"name":284,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":400,"status":265,"city":401,"state":375,"zip":402,"country":269,"countryCode":270,"cosmosGeoPoint":403,"geoPoint":407,"contacts":408},"Mercy Cancer Center - Carmichael","Carmichael","95608",{"type":272,"coordinates":404},[405,406],-121.32828,38.61713,{"lat":406,"lon":405},[409,410],{"name":279,"role":280,"phone":353,"phoneExt":224,"email":354},{"name":356,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":412,"status":265,"city":401,"state":375,"zip":402,"country":269,"countryCode":270,"cosmosGeoPoint":413,"geoPoint":415,"contacts":416},"Mercy San Juan Medical Center",{"type":272,"coordinates":414},[405,406],{"lat":406,"lon":405},[417,420],{"name":279,"role":280,"phone":418,"phoneExt":224,"email":419},"916-556-3301","OncologyResearch@DignityHealth.org",{"name":356,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":422,"status":265,"city":423,"state":375,"zip":424,"country":269,"countryCode":270,"cosmosGeoPoint":425,"geoPoint":429,"contacts":430},"City of Hope Corona","Corona","92882",{"type":272,"coordinates":426},[427,428],-117.56644,33.87529,{"lat":428,"lon":427},[431,434],{"name":279,"role":280,"phone":432,"phoneExt":224,"email":433},"626-256-4673","becomingapatient@coh.org",{"name":435,"role":261,"phone":224,"phoneExt":224,"email":224},"Scott M. Glaser",{"facility":437,"status":265,"city":438,"state":375,"zip":439,"country":269,"countryCode":270,"cosmosGeoPoint":440,"geoPoint":444,"contacts":445},"City of Hope Comprehensive Cancer Center","Duarte","91010",{"type":272,"coordinates":441},[442,443],-117.97729,34.13945,{"lat":443,"lon":442},[446,449],{"name":435,"role":280,"phone":447,"phoneExt":224,"email":448},"626-218-2247","sglaser@coh.org",{"name":435,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":451,"status":265,"city":452,"state":375,"zip":453,"country":269,"countryCode":270,"cosmosGeoPoint":454,"geoPoint":458,"contacts":459},"Mercy Cancer Center - Elk Grove","Elk Grove","95758",{"type":272,"coordinates":455},[456,457],-121.37162,38.4088,{"lat":457,"lon":456},[460,461],{"name":279,"role":280,"phone":353,"phoneExt":224,"email":354},{"name":356,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":463,"status":265,"city":464,"state":375,"zip":465,"country":269,"countryCode":270,"cosmosGeoPoint":466,"geoPoint":470,"contacts":471},"UC San Diego Health System - Encinitas","Encinitas","92024",{"type":272,"coordinates":467},[468,469],-117.29198,33.03699,{"lat":469,"lon":468},[472,474],{"name":279,"role":280,"phone":473,"phoneExt":224,"email":224},"760-536-7700",{"name":475,"role":261,"phone":224,"phoneExt":224,"email":224},"James M. Randall",{"facility":477,"status":265,"city":478,"state":375,"zip":479,"country":269,"countryCode":270,"cosmosGeoPoint":480,"geoPoint":484,"contacts":485},"UC San Diego Moores Cancer Center","La Jolla","92093",{"type":272,"coordinates":481},[482,483],-117.2742,32.84727,{"lat":483,"lon":482},[486,489],{"name":279,"role":280,"phone":487,"phoneExt":224,"email":488},"858-822-5354","cancercto@ucsd.edu",{"name":475,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":491,"status":265,"city":492,"state":375,"zip":493,"country":269,"countryCode":270,"cosmosGeoPoint":494,"geoPoint":498,"contacts":499},"City of Hope Antelope 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Schuster",{"facility":3972,"status":265,"city":3958,"state":3913,"zip":3973,"country":269,"countryCode":270,"cosmosGeoPoint":3974,"geoPoint":3976,"contacts":3977},"University of Wisconsin Carbone Cancer Center - Eastpark Medical Center","53718",{"type":272,"coordinates":3975},[3962,3963],{"lat":3963,"lon":3962},[3978,3979],{"name":279,"role":280,"phone":3952,"phoneExt":224,"email":3953},{"name":3955,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":3981,"status":265,"city":3958,"state":3913,"zip":3982,"country":269,"countryCode":270,"cosmosGeoPoint":3983,"geoPoint":3985,"contacts":3986},"University of Wisconsin Carbone Cancer Center - University Hospital","53792",{"type":272,"coordinates":3984},[3962,3963],{"lat":3963,"lon":3962},[3987,3988],{"name":279,"role":280,"phone":3952,"phoneExt":224,"email":3953},{"name":3955,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":3990,"status":265,"city":3991,"state":3913,"zip":3992,"country":269,"countryCode":270,"cosmosGeoPoint":3993,"geoPoint":3997,"contacts":3998},"Marshfield Medical Center-Marshfield","Marshfield","54449",{"type":272,"coordinates":3994},[3995,3996],-90.1718,44.66885,{"lat":3996,"lon":3995},[3999,4000],{"name":279,"role":280,"phone":3937,"phoneExt":224,"email":3938},{"name":3940,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4002,"status":265,"city":4003,"state":3913,"zip":4004,"country":269,"countryCode":270,"cosmosGeoPoint":4005,"geoPoint":4009,"contacts":4010},"Marshfield Medical Center - Minocqua","Minocqua","54548",{"type":272,"coordinates":4006},[4007,4008],-89.71098,45.87134,{"lat":4008,"lon":4007},[4011,4012],{"name":279,"role":280,"phone":3937,"phoneExt":224,"email":3938},{"name":3940,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4014,"status":265,"city":4015,"state":3913,"zip":4016,"country":269,"countryCode":270,"cosmosGeoPoint":4017,"geoPoint":4021,"contacts":4022},"Cancer Center of Western Wisconsin","New Richmond","54017",{"type":272,"coordinates":4018},[4019,4020],-92.53659,45.12302,{"lat":4020,"lon":4019},[4023,4024],{"name":279,"role":280,"phone":1825,"phoneExt":224,"email":1826},{"name":1828,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4026,"status":265,"city":4027,"state":3913,"zip":4028,"country":269,"countryCode":270,"cosmosGeoPoint":4029,"geoPoint":4033,"contacts":4034},"Aspirus Cancer Care - James Beck Cancer Center","Rhinelander","54501",{"type":272,"coordinates":4030},[4031,4032],-89.41208,45.63662,{"lat":4032,"lon":4031},[4035,4038],{"name":279,"role":280,"phone":4036,"phoneExt":224,"email":4037},"715-847-2353","Beth.Knetter@aspirus.org",{"name":3925,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4040,"status":265,"city":4041,"state":3913,"zip":4042,"country":269,"countryCode":270,"cosmosGeoPoint":4043,"geoPoint":4047,"contacts":4048},"Marshfield Medical Center-Rice Lake","Rice Lake","54868",{"type":272,"coordinates":4044},[4045,4046],-91.73823,45.50607,{"lat":4046,"lon":4045},[4049,4050],{"name":279,"role":280,"phone":3937,"phoneExt":224,"email":3938},{"name":3940,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4052,"status":265,"city":4053,"state":3913,"zip":4054,"country":269,"countryCode":270,"cosmosGeoPoint":4055,"geoPoint":4059,"contacts":4060},"Aspirus Cancer Care - Stevens Point","Stevens Point","54481",{"type":272,"coordinates":4056},[4057,4058],-89.57456,44.52358,{"lat":4058,"lon":4057},[4061,4062],{"name":279,"role":280,"phone":4036,"phoneExt":224,"email":4037},{"name":3925,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4064,"status":265,"city":4053,"state":3913,"zip":4065,"country":269,"countryCode":270,"cosmosGeoPoint":4066,"geoPoint":4068,"contacts":4069},"Marshfield Medical Center-River Region at Stevens Point","54482",{"type":272,"coordinates":4067},[4057,4058],{"lat":4058,"lon":4057},[4070,4071],{"name":279,"role":280,"phone":3937,"phoneExt":224,"email":3938},{"name":3940,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4073,"status":265,"city":4074,"state":3913,"zip":4075,"country":269,"countryCode":270,"cosmosGeoPoint":4076,"geoPoint":4080,"contacts":4081},"Aspirus Regional Cancer Center","Wausau","54401",{"type":272,"coordinates":4077},[4078,4079],-89.63012,44.95914,{"lat":4079,"lon":4078},[4082,4084],{"name":279,"role":280,"phone":4083,"phoneExt":224,"email":224},"877-405-6866",{"name":3925,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4086,"status":265,"city":4087,"state":3913,"zip":4088,"country":269,"countryCode":270,"cosmosGeoPoint":4089,"geoPoint":4093,"contacts":4094},"Marshfield Medical Center - Weston","Weston","54476",{"type":272,"coordinates":4090},[4091,4092],-89.54762,44.8908,{"lat":4092,"lon":4091},[4095,4096],{"name":279,"role":280,"phone":3937,"phoneExt":224,"email":3938},{"name":3940,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4098,"status":265,"city":4099,"state":3913,"zip":4100,"country":269,"countryCode":270,"cosmosGeoPoint":4101,"geoPoint":4105,"contacts":4106},"Aspirus Cancer Care - Wisconsin Rapids","Wisconsin Rapids","54494",{"type":272,"coordinates":4102},[4103,4104],-89.81735,44.38358,{"lat":4104,"lon":4103},[4107,4109],{"name":279,"role":280,"phone":4108,"phoneExt":224,"email":224},"715-422-7718",{"name":3925,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4111,"status":265,"city":4112,"state":4113,"zip":4114,"country":269,"countryCode":270,"cosmosGeoPoint":4115,"geoPoint":4119,"contacts":4120},"Memorial Hospital of Laramie County","Cheyenne","Wyoming","82001",{"type":272,"coordinates":4116},[4117,4118],-104.82025,41.13998,{"lat":4118,"lon":4117},[4121,4122],{"name":279,"role":280,"phone":224,"phoneExt":224,"email":2473},{"name":951,"role":261,"phone":224,"phoneExt":224,"email":224},{"facility":4124,"status":312,"city":4125,"state":4113,"zip":4126,"country":269,"countryCode":270,"cosmosGeoPoint":4127,"geoPoint":4131,"contacts":224},"Welch Cancer Center","Sheridan","82801",{"type":272,"coordinates":4128},[4129,4130],-106.95618,44.79719,{"lat":4130,"lon":4129},{"type":4133,"investigatorFullName":224,"investigatorTitle":224,"investigatorAffiliation":224,"oldNameTitle":224,"oldOrganization":224},"SPONSOR",[4135],{"name":4136,"class":4137},"National Cancer Institute (NCI)","NIH","100394987","phase-3-treating-prostate-cancer-that-has-come-back-after-surgery-with-apalutamide-and-targeted-radiation-based-on-pet-imaging-100394987",false,"NCT04423211","Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging","Phase III Study of Local or Systemic Therapy INtensification DIrected by PET in Prostate CAncer Patients With Post-ProstaTEctomy Biochemical Recurrence (INDICATE)","Inclusion Criteria:\n\n* STEP 0: REGISTRATION ELIGIBILITY CRITERIA\n* Patient must be male and \\>= 18 years of age.\n* Patient must have had a radical prostatectomy (RP) as definitive therapy for histopathologically-proven prostatic adenocarcinoma\n* Patient must have biochemical recurrence (BCR) after RP, defined as follows:\n\n  * If time to BCR, defined as time to first detectable PSA ( \\> lower limit of normal for assay used) after RP, is \\\u003C 12 months, a minimum PSA level of \\>= 0.2 ng\u002FmL and a confirmatory reading of \\>= 0.2 ng\u002FmL is required, per the American Urological Association (AUA) definition (Note: patients with a persistent PSA reading of at least 0.2 ng\u002FmL are eligible)\n  * If time to BCR, defined as time to first detectable PSA (\\> lower limit of normal for assay used) after RP, is \\>= 12 months, a minimum absolute PSA of 0.5 ng\u002FmL is required\n  * If the patient has a detectable PSA (\\> lower limit of normal for assay used) at any time after RP AND has an eligible baseline SOC PET (PET1) with at least one positive lesion in any location, then there is no minimum PSA requirement\n* Patients must have no definite evidence for extrapelvic metastatic disease by conventional imaging modalities (CIM) (CT abdomen\u002Fpelvis or MRI abdomen\u002Fpelvis AND bone scintigraphy, or equivalent), within 26 weeks prior to Step 0 registration. If a patient only has a study-eligible PET\u002FCT or PET\u002FMR (i.e., PET done without prior CIM): if the PET is negative for extrapelvic lesions, then baseline CIM is NOT required. If the PET positive for extrapelvic lesions, then patient should have a baseline CT\u002FMRI for soft tissue lesions and\u002For a bone scan for osseous lesions\n\n  * Study eligible = PET using FDA-approved radiotracer and performed within 16 weeks prior to study registration\n* Extra-pelvic metastases is defined as any osseous metastases and\u002For any extrapelvic soft tissue, lymph nodes and organ metastases; extra-pelvic is defined as superior to common iliac bifurcation, outside of standard prostate bed + whole pelvis nodal RT fields. Baseline PET\u002FCT or PET\u002FMR scan (PET1) is eligible for this study if the SOC PET scan is completed with an FDA approved radiotracer for prostate cancer after Step 0 registration and prior to Step 1 randomization OR up to 16 weeks prior to Step 0 registration\n* Patient must be a candidate for SOC post-prostatectomy radiation therapy (RT) to the prostate bed and pelvic nodes with androgen deprivation therapy (ADT)\n* Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and\u002For family member available will also be considered eligible\n* Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2\n* Patient must not have started ADT for biochemical recurrence prior to baseline PET (PET1) imaging. A short course of low-dose anti-androgen such as bicalutamide, given after baseline study PET\u002FCT but prior to study registration, is permitted as a brief temporizing measure in advance of starting protocol-approved SOC ADT.\n* Patient must not be enrolled in another therapeutic clinical trial\n* Patient must be able to lie flat and still for approximately 20-30 minutes or otherwise tolerate a PET scan and radiation treatment planning and delivery\n* Patients undergoing a PET\u002FMR must meet local institutional safety guidelines for MRI\n* Patient must not have history of seizures or known condition that may cause predisposal to seizures (e.g., stroke or head trauma resulting in loss of consciousness) within 1 year prior to registration\n* Patient must not have history of inflammatory bowel disease or any gastrointestinal disorder affecting absorption that is expected to increase risk of complication from radiotherapy\n* Hemoglobin (Hgb) \\>= 9.0 g\u002FdL (independent of transfusion and\u002For growth factors within 3 months prior to Step 0 registration) (obtained within 8 weeks prior to Step 0 registration)\n* Leukocytes \\>= 3,000\u002FmcL (obtained within 8 weeks prior to Step 0 registration)\n* Absolute neutrophil count \\>= 1,500\u002FmcL (obtained within 8 weeks prior to Step 0 registration)\n* Platelets \\>= 100,000\u002FmcL (obtained within 8 weeks prior to Step 0 registration)\n* Total bilirubin \\\u003C 1.5 x institutional upper limit of normal (ULN) (patients with Gilbert's syndrome, if total bilirubin is \\> 1.5 x ULN, must have a direct bilirubin of \\\u003C 1.5 x ULN to be eligible) (obtained within 8 weeks prior to Step 0 registration)\n* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \\[SGOT\\])\u002Falanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \\[SGPT\\]) =\\\u003C 2.5 x institutional ULN (obtained within 8 weeks prior to Step 0 registration)\n* Creatine \\\u003C 1.5 x instituional ULN (or measured creatinine clearance \\> 30 mL\u002Fmin)\n* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial\n* Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class I or II (by patient symptoms) or A or B (by objective assessment)\n* Patient must not have completed a course of prior pelvic radiation therapy for any reason\n* Patient must agree not to father children while on study\n* Patient must be English or Spanish speaking to be eligible for the QOL component of the study\n\n  * NOTE: Sites cannot translate the associated QOL forms\n* STEP 1: RANDOMIZATION ELIGIBILITY CRITERIA\n* Patient must have completed a baseline SOC PET\u002FCT or PET\u002FMR (PET1 scan) using FDA approved radiotracer with results of extra-pelvic metastases involvement known (positive or negative). The PET1 must have been completed after Step 0 registration and prior to Step 1 randomization OR up to 12 weeks prior to Step 0 registration\n* For patients with negative extra-pelvic metastases, PET-imaging status of intra-pelvic nodes must be known (positive or negative)\n* For patients with positive extra-pelvic metastases (defined as any PET positive lesions outside of standard salvage RT fields \\[prostate bed +\u002F- typical whole pelvis\\]), the number of extra-pelvic lesions must be known (1 - 5 or \\> 5 extra-pelvic lesions)","MALE","18 Years",{"count":4148,"type":4149},804,"ESTIMATED","INTERVENTIONAL",[4152],"PHASE3","This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in patients with prostate cancer who experience biochemical recurrence (a rise in the blood level of prostate specific antigen \\[PSA\\] after surgical removal of the prostate cancer).\n\nA second question tests treatment in patients with biochemical recurrence who show prostate cancer spreading outside the pelvis (metastasis) by positron emission tomography (PET) imaging. In these patients, the benefit of adding metastasis-directed radiation to enhanced therapy (apalutamide in combination with abiraterone + prednisone) is tested.\n\nDiagnostic procedures, such as PET, may help doctors look for cancer that has spread to the pelvis. Androgens are hormones that may cause the growth of prostate cancer cells. Apalutamide may help fight prostate cancer by blocking the use of androgens by the tumor cells. Metastasis-directed targeted radiation therapy uses high energy rays to kill tumor cells and shrink tumors that have spread. This trial may help doctors determine if using PET results to deliver more tailored treatment (i.e., adding apalutamide, with or without targeted radiation therapy, to standard of care treatment) works better than standard of care treatment alone in patients with biochemical recurrence of prostate cancer.",[4155,4156,4157,4158],"Biochemically Recurrent Prostate Carcinoma","Metastatic Prostate Carcinoma","Prostate Adenocarcinoma","Stage IVB Prostate Cancer AJCC v8","2026-06-16",{"date":4161,"type":4162},"2026-06-18","ACTUAL",{"date":4164,"type":4162},"2020-10-08",{"date":4166,"type":4149},"2032-12-31",{"name":260,"class":6},342]