[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629936":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":22,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":18,"enrollmentInfo":59,"targetDuration":18,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":34,"whyStopped":18,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EX-CIPN Exercise-based Intervention","EXPERIMENTAL","This arm is provided with an intervention that includes an individualized exercise program, remote monitoring, and remote person-to-person clinical support.",[13],"Behavioral: EX-CIPN",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care Control","NO_INTERVENTION","This arm is provided usual oncology care and is provided the intervention after completing all study assessments (5-6 months)",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","EX-CIPN","The 10-week intervention includes: Individualized Exercise Program: Each participant will receive an individualized progressive exercise program that includes cardiovascular and strength training as well as balance and desensitization exercises specific to CIPN symptoms. Remote Monitoring: Fitbit™ devices will be used to monitor patients' physical activity over the duration of the program. Fitness trackers can promote behaviour change. Remote Person-to-Person Clinical Support: Participants will have scheduled remote check-ins and health coaching sessions with their assigned RKin on weeks 2, 3, 4, 6, and 8 of the intervention. During these calls, the RKin will progress the exercise program as needed, discuss and develop goals, and identify potential barriers and solutions in achieving their goals.\n\nAfter the 10-week intervention participants will receive a 3-month maintenance phase with 2 monthly remote check-ins.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Eric Antonen, MSc","CONTACT","416-634-7784","eric.antonen2@uhn.ca",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"ELLICSR: Health Wellness and Cancer Survivorship Centre","RECRUITING","Toronto","Ontario","M5G 2N2","Canada","CA",{"type":41,"coordinates":42},"Point",[43,44],-79.39864,43.70643,{"lat":44,"lon":43},[47],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},{"type":49,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100629936","phase-3-trial-of-a-virtual-exercise-based-rehabilitation-program-to-treat-persistent-chemotherapy-induced-peripheral-neuropathy-cipn-100629936",false,"NCT07481149","Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)","A Pragmatic Randomized Controlled Trial of a Virtual Exercise-based Rehabilitation Intervention for Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN).","Inclusion Criteria:\n\n* diagnosed with any type of cancer\n* received chemotherapy treatment as part of curative-intent therapy (no minimum dose)\n* \\>6 months following chemotherapy completion with no current plans for further chemotherapy\n* report Grade 1 or higher on the numbness and tingling severity item of the Common Terminology Criteria for Adverse Events (CTCAE) v 5.0\n* neuropathic pain 3 or higher on the Neuropathic Pain 4 (DN4) (interview)\n* capable of ambulation and transfers (with or without gait\u002Ftransfer aid) (ECOG score 0-2)\n* are able to communicate sufficiently in English to complete intervention, questionnaires, and consent\n* have access to and able to operate videoconferencing\n\nExclusion Criteria:\n\n* currently meeting all recommendations from the physical activity guidelines for cancer survivors\n* have any neurological conditions influencing cognition (i.e. dementia, Alzheimer's) and preventing safe or appropriate engagement with exercise recommendation\n* have neuropathy that pre-existed chemotherapy receipt (i.e. diabetic neuropathy)\n* currently enrolled in other rehabilitation or exercise-based interventions","ALL","18 Years",{"count":60,"type":61},240,"ESTIMATED","INTERVENTIONAL",[64],"PHASE3","The purpose of this study is to determine the effectiveness of the EX-CIPN program in reducing the strength of CIPN symptoms and CIPN-related disability and improving the ability to complete everyday activities. This will be done by determining whether it is better to receive the EX-CIPN program or better to receive no additional intervention. To do this, some of the participants in this study will get EX-CIPN and others will receive usual care. Those who receive usual care will be offered EX-CIPN upon study completion. The main question it aims to answer is:\n\n• Is EX-CIPN effective in improving CIPN symptoms for cancer survivors experiencing persistent CIPN?\n\nParticipants in both study groups will be asked to:\n\n• Complete assessments at baseline, immediately post-intervention, and 3-months post-intervention\n\nParticipants in the EX-CIPN group will be asked to:\n\n* Complete an additional aassessment at 6-months post-intervention\n* Complete a 10-week remote, individualized exercise program\n* Receive health coaching calls on weeks 2, 3, 4, 6, and 8 of the intervention\n* Wear a FitBit throughout the study to track physical activity and promote behaviour change",[67],"Chemotherapy-induced Peripheral Neuropathy (CIPN)",[69,70,71],"cancer rehabilitation","peripheral neuropathy","randomized controlled trial","2026-06-03",{"date":74,"type":75},"2026-06-05","ACTUAL",{"date":77,"type":75},"2026-03-30",{"date":79,"type":61},"2029-07",{"name":5,"class":6},1]