[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477154":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":43,"responsibleParty":70,"collaborators":74,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":32,"eligibilityCriteria":87,"healthyVolunteers":84,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":32,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":45,"whyStopped":32,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Shanghai Pulmonary Hospital, Shanghai, China","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Vγ2Vδ2 T lymphocyte-based immunotherapy +Treatment regimens for MDR-TB","EXPERIMENTAL","Treatment was based on the principles of the WHO guidelines for the treatment of drug-resistant tuberculosis, with the addition of immunotherapy：zoledronic acid and recombinant human interleukin 2",[13,14],"Drug: Vγ2Vδ2 T lymphocyte-based immunotherapy","Drug: Treatment regimens for MDR-TB",{"label":16,"type":17,"description":18,"interventionNames":19},"Treatment regimens for MDR-TB","ACTIVE_COMPARATOR","Treatment regimens was based on the principles of the WHO guidelines for the treatment of drug-resistant tuberculosis.",[14],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vγ2Vδ2 T lymphocyte-based immunotherapy","Intravenous injection of zoledronic acid, followed by a subcutaneous injection recombinant human interleukin. Zoledronic acid was administered 3 times and recombinant human interleukin was administered 10 times for a total of 6 months.",[9],[27],"Drug combination (zoledronic acid\u002Finterleukin 2)",{"type":22,"name":16,"description":18,"armGroupLabels":29,"otherNames":30},[16,9],[31],"Treatment regimen for MDR-TB using WHO guidelines",null,[34,40],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Sha Wei","CONTACT","+8602165115006","2017","13671758200@126.com",{"name":41,"role":36,"phone":37,"phoneExt":38,"email":42},"Liu Yidian","13816676933@139.com",[44,62],{"facility":5,"status":45,"city":46,"state":32,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Shanghai","200433","China","CN",{"type":51,"coordinates":52},"Point",[53,54],121.45806,31.22222,{"lat":54,"lon":53},[57,59],{"name":58,"role":36,"phone":37,"phoneExt":38,"email":39},"sha wei",{"name":60,"role":36,"phone":37,"phoneExt":61,"email":42},"liu yidian","2011",{"facility":63,"status":45,"city":46,"state":32,"zip":32,"country":48,"countryCode":49,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Shanghai Pulmonary Hospital",{"type":51,"coordinates":65},[53,54],{"lat":54,"lon":53},[68],{"name":69,"role":36,"phone":37,"phoneExt":38,"email":42},"Liu yidian",{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Wei Sha MD & PhD","Director, Head of Tuberculosis Department,Shanghai Pulmonary Hospital, Principal Investigator, Clinical Professor",[75,78,80],{"name":76,"class":77},"Shanghai Public Health Clinical Center","OTHER_GOV",{"name":79,"class":6},"Huashan Hospital",{"name":81,"class":6},"No.85 Hospital, Changning, Shanghai, China","100477154","phase-4-a-exploratory-study-of-v2v2-t-lymphocyte-based-immunotherapy-for-mdr-tb-100477154",false,"NCT05493267","A Exploratory Study of Vγ2Vδ2 T Lymphocyte-based Immunotherapy for MDR-TB","Inclusion Criteria:\n\n* RR-TB\u002FMDR-TB (resistant to at least isoniazid and rifampicin).\n* Poor efficacy of the original treatment regimen or no response to treatment or less than 4 effective drugs.\n\nExclusion Criteria:\n\n* Immunosuppression due to co-morbidities, such as immune system disorders, tumors, etc.\n* Test confirms poor response to ZOL and IL-2 stimulation.","ALL","18 Years","65 Years",{"count":92,"type":93},30,"ESTIMATED","INTERVENTIONAL",[96],"PHASE4","A Exploratory Study of drug combination (zoledronic acid\u002Finterleukin 2) that specifically amplifies Vγ2Vδ2 T cells in combination with anti-tuberculosis chemotherapy for the treatment of MDR-TB.",[99,100],"MDR-TB","Immunotherapy",[102],"MDR-TB；Immunotherapy；","2022-08-08",{"date":105,"type":106},"2022-08-10","ACTUAL",{"date":108,"type":106},"2022-08-03",{"date":110,"type":93},"2027-08-03",{"name":5,"class":6},2]