[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100533759":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":27,"locations":33,"responsibleParty":48,"collaborators":18,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":18,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":35,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Chiang Mai University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Protocol based-furosemide stress test","EXPERIMENTAL","Furosemide at 1.5 mg\u002Fkg intravenously",[13],"Drug: Furosemide Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care","NO_INTERVENTION","Standard CRRT care without furosemide use during treatment.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Furosemide Injection","After taking furosemide at 1.5 mg\u002Fkg intravenously, if the urine output exceeds 200 mL within 2 hours, the patients are going to withhold CRRT. But if there is no response, the titration of furosemide to 2.5 mg\u002Fkg and 3.5 mg\u002Fkg every 6 hours is scheduled according to the urine output \\>200 mL in 2 hours (not exceeding 250 mg).",[9],[26],"Furosemide stress test",[28],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},"Prit Kusirisin, MD","CONTACT","+66897574028","jingprit@hotmail.com",[34],{"facility":5,"status":35,"city":36,"state":18,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Chiang Mai","50200","Thailand","TH",{"type":41,"coordinates":42},"Point",[43,44],98.98468,18.79038,{"lat":44,"lon":43},[47],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},{"type":49,"investigatorFullName":29,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Principal investigator","100533759","phase-4-a-protocol-based-furosemide-stress-test-to-evaluate-renal-recovery-during-continuous-renal-replacement-therapy-100533759",false,"NCT06229990","A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy","A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy (FST-STOP): A Randomized Controlled Trial","FST-STOP","Inclusion Criteria:\n\n* Adult 20 year of age or older\n* Acute kidney injury (AKI) stage 3 according to Kidney Disease Improving Global Outcomes (KDIGO) classification with oliguria (urine \\\u003C400 ml\u002Fday)\n* Initiate CRRT in ICU (medical ICU, surgical ICU, cardiac care unit) for at least 48 hours (time for initiation and modality of CRRT can adjust by clinician)\n\nExclusion Criteria:\n\n* Use any inotropic drug (norepinephrine, epinephrine, dopamine, dobutamine)\n* Blood urea nitrogen (BUN) \\>80 mg\u002FdL\n* Serum K \\\u003C3.5 or \\>5 mmol\u002FL\n* Arterial potential of Hydrogen (pH) \\\u003C7.3\n* Serum bicarbonate (HCO3) \\\u003C15 mmol\u002FL\n* Urine volume \\\u003C400 or \\>2,100 mL\u002Fday\n* Urine creatinine clearance (CrCl) at 6 hours \\>20 mL\u002Fmin\n* Previous chronic kidney disease (CKD) stage 5 or estimated glomerular filtration rate (eGFR) \\\u003C15 mL\u002Fmin\u002F1.73 m2\n* Previous RRT within 14 days\n* Kidney transplantation\n* Obstructive etiology for AKI\n* Toxin\u002Fdrug that necessitates RRT\n* Allergy to furosemide\n* Moribund with expected death within 24 hours\n* Pregnancy","ALL","20 Years",{"count":62,"type":63},80,"ESTIMATED","INTERVENTIONAL",[66],"PHASE4","Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation. However, prolonged CRRT demonstrated the association of many unexpected events, such as catheter-related complications, catheter-related blood stream infection, hypotension, hypothermia, tachycardia, and atrial fibrillation. Up to now, there is a lack of evidence regarding the timing of withholding CRRT. The furosemide stress test (FST) is a tool that is easy to use and has more availability. The investigators aimed to apply FST to evaluate renal recovery compared with standard treatment in critically ill patients undergoing CRRT.",[69],"Acute Kidney Injury",[71,72,26,73,74],"Acute kidney injury","Continuous renal replacement therapy","Critical care","CRRT","2026-03-20",{"date":77,"type":78},"2026-03-24","ACTUAL",{"date":80,"type":78},"2024-01-01",{"date":82,"type":63},"2028-12-31",{"name":5,"class":6},1]