[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625591":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":61,"collaborators":43,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":43,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":43,"enrollmentInfo":73,"targetDuration":43,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":85,"whyStopped":43,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tris-hydroxymethyl aminomethane (THAM)","EXPERIMENTAL","Patients randomized to the THAM arm will be treated with tris-hydroxymethyl aminomethane.\n\nDosage: Base excess less than -5, administer 500 mL of THAM",[13],"Drug: Tris-hydroxymethyl Aminomethane",{"label":15,"type":16,"description":17,"interventionNames":18},"Sodium bicarbonate (Bicarb)","ACTIVE_COMPARATOR","Patients randomized to the Bicarb arm will be treated with sodium bicarbonate (Bicarb).\n\nDosage: Base excess less than -5, administer 100 mEq of sodium bicarbonate",[19],"Drug: Sodium bicarbonate",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Sodium bicarbonate","Patients in the ICU following cardiothoracic surgery with use of cardiopulmonary bypass and requiring treatment for metabolic acidosis (base excess less than -5), will receive sodium bicarbonate (Bicarb) if randomized to the Bicarb arm.",[15],[27],"Bicarb",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Tris-hydroxymethyl Aminomethane","Patients in the ICU following cardiothoracic surgery with use of cardiopulmonary bypass, requiring treatment for metabolic acidosis (base excess less than -5), will receive tris-hydroxymethyl aminomethane (THAM) if randomized to the THAM arm.",[9],[33],"THAM",[35],{"name":36,"affiliation":5,"role":37},"Misty A. Radosevich, MD","PRINCIPAL_INVESTIGATOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Nicole M. Lenort, RRT, LRT","CONTACT","866-265-9263",null,"Lenort.Nicole@mayo.edu",[46],{"facility":5,"status":43,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Rochester","Minnesota","55901","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-92.4699,44.02163,{"lat":56,"lon":55},[59,60],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":43},{"name":36,"role":37,"phone":43,"phoneExt":43,"email":43},{"type":37,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Misty Radosevich","Principal Investigator","100625591","phase-4-a-study-of-tris-hydroxymethyl-aminomethane-tham-versus-sodium-bicarbonate-in-cardiac-surgical-patients-100625591",false,"NCT07424625","A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients","THAM VErsus Sodium BiCarbOnate In CaRdiac SuRgical PatiEnts, A PragmatiC, Comparative-effectiveness Prospective Trial","* Inclusion criteria\n\n  * Cardiothoracic surgery with use of cardiopulmonary bypass\n  * Presence of metabolic acidosis (defined as a base excess of \\\u003C-5)\n  * Minnesota Research Authorization\n* Exclusion criteria\n\n  * Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass\n  * Absence of metabolic acidosis (metabolic acidosis being defined as a base excess of \\\u003C-5)\n  * Pregnant patients\n  * Prisoners\n  * Opt out of Minnesota Research Authorization","ALL","21 Years",{"count":74,"type":75},250,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.",[81],"Metabolic Acidosis",[33,23,83,84],"metabolic acidosis","cardiac surgery","NOT_YET_RECRUITING","2026-06-11",{"date":88,"type":89},"2026-06-15","ACTUAL",{"date":91,"type":75},"2026-07",{"date":93,"type":75},"2027-08",{"name":5,"class":6},1]