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(COPD) who meet the following criteria at screening:\n\n* Current or former smokers with a smoking history of ≥10 pack-years\n* Moderate-to-severe COPD (post-BD FEV1\u002FFVC ratio \\\u003C0.70 and post-BD FEV1 % predicted \\>30% and ≤70%)\n* Medical Research Council Dyspnea Scale grade ≥2 or COPD assessment test (CAT) score ≥10\n* Global Initiative for Chronic Obstructive Lung Disease (GOLD) category E , Frequent or severe exacerbations\n* Background triple therapy (ICS + LABA + LAMA) for 3 months before randomization with a stable dose of medication for ≥1 month before Visit 1; dual therapy (LABA + LAMA) allowed if ICS is contraindicated\n* Evidence of Type 2 inflammation: Participants with blood eosinophils ≥300 cells\u002FμL at screening or with blood eosinophils ≥150 cells\u002FμL at Visit 1 (screening) and with a history of blood eosinophils ≥300 cells\u002FμL within the past year during stable state (non-exacerbation).\n* Mucus score cutoff of ≥3\n\nExclusion Criteria:\n\n* A current diagnosis of asthma according to the Global Initiative for Asthma diagnostic (GINA) guidelines, or documented history of asthma\n* Significant pulmonary disease other than COPD (eg, lung fibrosis, sarcoidosis, interstitial lung disease, pulmonary hypertension, bronchiectasis, Churg-Strauss Syndrome) or another diagnosed pulmonary or systemic disease associated with elevated peripheral eosinophil counts\n* Treatment with oxygen \\>4.0 L\u002Fmin for ≥8 hours\u002Fday Respiratory tract infection within 4 weeks before screening, or during the screening period\n* Diagnosis of α-1 anti-trypsin deficiency\n* Any biologic therapy (including experimental treatments and dupilumab)\n* Participants on treatment with mucolytics unless on stable therapy for \\>6 months\n\nThe above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.","ALL","40 Years","85 Years",{"count":712,"type":713},218,"ESTIMATED","INTERVENTIONAL",[716],"PHASE4","LPS18583 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 4 study with 2 treatment groups. The purpose of this study is to assess the effect of dupilumab compared with placebo on airway inflammation, resistance, and remodeling including mucus plugging and its association with improvement on lung function, exacerbations, and quality of life improvement in participants aged 40 years of age up to 85 years of age (inclusive).\n\nStudy details include:\n\nThe study duration will be up to 40 weeks. The treatment duration will be up to 24 weeks. The number of visits will be 9.",[719],"Chronic Obstructive Pulmonary Disease","2026-06-11",{"date":722,"type":723},"2026-06-12","ACTUAL",{"date":725,"type":723},"2025-09-22",{"date":727,"type":713},"2029-02-02",{"name":5,"class":6},68]