[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505038":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":28,"locations":33,"responsibleParty":57,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":28,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":28,"enrollmentInfo":73,"targetDuration":28,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":36,"whyStopped":28,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound Shear Wave Elastography Examination - Lower","EXPERIMENTAL","Subjects identified as being administered low dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.",[13],"Drug: Fentanyl Injection",{"label":15,"type":10,"description":16,"interventionNames":17},"Ultrasound Shear Wave Elastography Examination - Mid","Subjects identified as being administered mid dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Ultrasound Shear Wave Elastography Examination - Higher","Subjects identified as being administered higher dose opioids during an elective lower extremity orthopedic surgery per standard of care will undergo an ultrasound shear wave elastography examination while performing different breathing techniques.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Fentanyl Injection","Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing",[19,9,15],null,[30],{"name":31,"affiliation":5,"role":32},"Carlos Mantilla, MD, PhD","PRINCIPAL_INVESTIGATOR",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Mayo Clinic Minnesota","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-92.4699,44.02163,{"lat":46,"lon":45},[49,54],{"name":50,"role":51,"phone":52,"phoneExt":28,"email":53},"Beth Martin","CONTACT","866-265-9263","martin.elizabeth@mayo.edu",{"name":55,"role":51,"phone":52,"phoneExt":28,"email":56},"Brenda Anderson","anderson.brenda@mayo.edu",{"type":32,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Carlos B Mantilla, MD, PhD","Principal Investigator",[61],{"name":62,"class":63},"National Institute on Drug Abuse (NIDA)","NIH","100505038","phase-4-a-study-to-investigate-of-the-effects-of-opioid-exposure-on-the-ability-of-the-diaphragm-muscle-100505038",false,"NCT05856136","A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle","Investigation of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle to Generate Higher Force Behaviors","Inclusion Criteria:\n\n\\- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).\n\nExclusion Criteria:\n\n* Patients who refuse research participation.\n* Patients who are pregnant.\n* Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).","ALL","18 Years",{"count":74,"type":75},69,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.",[81,82],"Respiratory Function Loss","Respiratory Complication",[84,85],"elastography","ultrasound","2026-06-18",{"date":88,"type":89},"2026-06-23","ACTUAL",{"date":91,"type":89},"2023-06-19",{"date":93,"type":75},"2027-01-01",{"name":5,"class":6},1]