[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100450354":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":23,"centralContacts":23,"locations":28,"responsibleParty":61,"collaborators":23,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":23,"enrollmentInfo":74,"targetDuration":23,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":23,"overallStatus":31,"whyStopped":23,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Herlev Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Accelerated antibiotic treatment","EXPERIMENTAL","Patients are treated shorter than usual",[13],"Other: Accelerated antibiotic treatment",{"label":15,"type":6,"description":16,"interventionNames":17},"Standard length of antibiotic treatment","Patients are receiving the standard length of antibiotic treatment",[18],"Other: Standard treatment length",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"E. faecalis uncomplicated: 4 weeks.\n\nE. faecalis complicated: 4 weeks.\n\nS. aureus uncomplicated: 2 weeks.\n\nS. aureus complicated: 4 weeks.\n\nStreptococci spp. NVE: 2 weeks.\n\nStreptococci spp. PVE or abscess: 3 weeks.\n\nSubsequent to cardiac surgery with a negative valve culture (organism NOT grown in laboratory from valve): Minimum 1 week after surgery regardless of previous antibiotic treatment received.\n\nSubsequent to cardiac surgery with a positive valve culture (organism grown in laboratory from valve): treatment will continue with the start date of antibiotics changed to the date of surgery.\n\nComplicated IE defined as patients with abscess, embolic event, surgically treated IE, and\u002For PVE.\n\nNVE: native valve endocarditis, PVE: prosthetic valve endocarditis.",[9],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Standard treatment length","E. faecalis uncomplicated: 6 weeks.\n\nE. faecalis complicated: 6 weeks.\n\nS. aureus uncomplicated: 4 weeks.\n\nS. aureus complicated: 6 weeks.\n\nStreptococci spp. NVE: 4 weeks.\n\nStreptococci spp. PVE or abscess: 6 weeks.\n\nSubsequent to cardiac surgery with a negative valve culture (organism NOT grown in laboratory from valve): Minimum 2 weeks after surgery regardless of previous antibiotic treatment received.\n\nSubsequent to cardiac surgery with a positive valve culture (organism grown in laboratory from valve): treatment will continue with the start date of antibiotics changed to the date of surgery.\n\nComplicated IE defined as patients with abscess, embolic event, surgically treated IE, and\u002For PVE.\n\nNVE: native valve endocarditis, PVE: prosthetic valve endocarditis.",[15],[29,48],{"facility":30,"status":31,"city":32,"state":23,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Rigshositalet","RECRUITING","Copenhagen","2100","Denmark","DK",{"type":37,"coordinates":38},"Point",[39,40],12.56553,55.67594,{"lat":40,"lon":39},[43],{"name":44,"role":45,"phone":46,"phoneExt":23,"email":47},"Henning Bundgaard","CONTACT","+4535450512","henning.bundgaard@regionh.dk",{"facility":5,"status":31,"city":49,"state":23,"zip":50,"country":34,"countryCode":35,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Herlev","2730",{"type":37,"coordinates":52},[53,54],12.43998,55.72366,{"lat":54,"lon":53},[57],{"name":58,"role":45,"phone":59,"phoneExt":23,"email":60},"kasper iversen","+4538686009","kasper.karmark.iversen@regionh.dk",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Kasper Iversen","Associate professor","100450354","phase-4-accelerated-treatment-of-endocarditis-100450354",false,"NCT05144399","Accelerated Treatment of Endocarditis","POET II","Inclusion Criteria:\n\n* Admitted with left-sided infectious endocarditis (duke criteria)\n* \\\u003C 14 days of relevant antibiotic treatment for endocarditis\n* One of the following bacteria: Streptococci, enterococcus faecalis, staphylococcus aureus\n* \\> 18 years old\n\nExclusion Criteria:\n\n* Known immune incompetency,\n* Relapse endocarditis with 6 months,\n* Unable to give informed concent","ALL","18 Years",{"count":75,"type":76},475,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks one or more types of intravenously administered antibiotics. The long hospitalization increases several risks for the patient, including mental strain and increased loss of function. Furthermore, it poses a significant financial burden on the health systems. Current guidelines fail to use available clinical and paraclinical, data collected from patients (echo, temperature, CRP, leukocytes, procalcitonin etc.) to determine duration of treatment. A strategy including these data in treatment algorithms ensures an individualized treatment, targeting the individual patient's course and response to treatment. Thus, the purpose of this open-label, prospective, non-inferiority, RCT study is to investigate the safety and effectiveness of shortening treatment of endocarditis based on the individual patient's initial treatment response, sampling 475 patients, approx. 125 patients with each type of bacteria (Streptococci; Enterococcus faecalis; Staphylococcus aureus).",[82],"Endocarditis","2024-01-17",{"date":85,"type":86},"2024-01-18","ACTUAL",{"date":88,"type":86},"2019-04-01",{"date":90,"type":76},"2026-12-31",{"name":5,"class":6},2]