[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560863":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":34,"centralContacts":39,"locations":49,"responsibleParty":71,"collaborators":11,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":11,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":11,"enrollmentInfo":83,"targetDuration":11,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":11,"overallStatus":52,"whyStopped":11,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,14,17,20,23,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo, then Propranolol, then Metoprolol","EXPERIMENTAL",null,[13],"Other: Ambient Heat",{"label":15,"type":10,"description":11,"interventionNames":16},"Placebo, then Metoprolol, then Propranolol",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Propranolol, then Placebo, then Metoprolol",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Propranolol, then Metoprolol, then Placebo",[13],{"label":24,"type":10,"description":11,"interventionNames":25},"Metoprolol, then Placebo, then Propranolol",[13],{"label":27,"type":10,"description":11,"interventionNames":28},"Metoprolol, then Propranolol, then Placebo",[13],[30],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":11},"Ambient Heat","Subjects will spend 3-hours in a heat chamber at 41°C and 40% humidity.",[24,27,15,9,21,18],[35],{"name":36,"affiliation":37,"role":38},"Craig Crandall, PhD","Univ of Texas Southwestern Med Ctr","PRINCIPAL_INVESTIGATOR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Erin Harper, MS","CONTACT","214-345-4737","erinharper@texashealth.org",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},"Courtney Kirby, RN","214-345-6502","courtneykirby@texashealth.org",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"IEEM Texas Health Presbyterian Hospital Dallas","RECRUITING","Dallas","Texas","75231","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-96.80667,32.78306,{"lat":62,"lon":61},[65,69,70],{"name":66,"role":42,"phone":67,"phoneExt":11,"email":68},"Taysom Wallace, MS","214-345-5022","taysomwallace@texashealth.org",{"name":46,"role":42,"phone":47,"phoneExt":11,"email":48},{"name":36,"role":38,"phone":11,"phoneExt":11,"email":11},{"type":38,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Craig Crandall","Professor of Internal Medicine","100560863","phase-4-aging-beta-blockers-and-thermoregulatory-responses-100560863",false,"NCT06582680","Aging, Beta Blockers, and Thermoregulatory Responses","Inclusion Criteria:\n\n* Healthy and free of any significant medical problems\n* Normal resting electrocardiogram\n* 65+ years of age\n* Controlled cholesterol of less than 200 mg\u002Fdl\n* Controlled blood pressure of less than 140\u002F90 mmHg\n\nExclusion Criteria:\n\n* Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia\n* Serious abnormalities detected on routine screening\n* Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating\n* Current smokers, as well as individuals who regularly smoked within the past 3 years\n* body mass index ≥31 kg\u002Fm2",true,"ALL","65 Years",{"count":84,"type":85},22,"ESTIMATED","INTERVENTIONAL",[88],"PHASE4","This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.",[91,92],"Heat Stress","Aging","2025-10-21",{"date":95,"type":96},"2025-10-23","ACTUAL",{"date":98,"type":96},"2024-10-04",{"date":100,"type":85},"2026-09-30",{"name":5,"class":6},1]