[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548661":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":49,"responsibleParty":234,"collaborators":236,"id":240,"slug":241,"hasResults":242,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":242,"sex":248,"minAge":249,"maxAge":44,"enrollmentInfo":250,"targetDuration":44,"studyType":253,"phases":254,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":52,"whyStopped":44,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":273},{"fullName":5,"class":6},"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous intravenous antibiotic infusion","EXPERIMENTAL","Ampicillin 12g\u002F24h plus ceftriaxone 4g\u002F12h continuous infusion. The duration of treatment will be 42 days.",[13],"Drug: Ampicillin plus ceftriaxone in continuous infusion",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard treatment","ACTIVE_COMPARATOR","Ampicillin 2g\u002F4h plus ceftriaxone 2g\u002F12h intermittent infusion for a minimum of 14 days. Starting on day 14 of treatment, if the patient is discharged from the hospital, the following treatments will be permitted:\n\n1. Intravenous treatment in TADE programs according to the following regimens:\n\n   1. Ampicillin 2g\u002F4h plus ceftriaxone 2g\u002F12h as an intermittent infusion\n   2. Teicoplanin 10-12mg\u002Fkg\u002F24h\n   3. Daptomycin 10-12mg\u002Fkg\u002F24h\n   4. Dalbavancin: Initial dose: 2 doses of 1500mg every 2 weeks. Maintenance dose: 1500mg every 15days.\n   5. Linezolid: 600mg\u002F12hours\n2. Oral treatment according to the following regimens:\n\n   1. Amoxicillin 1 g\u002F6h + Moxifloxacin 400mg\u002F24h.\n   2. Amoxicillin 1 g\u002F6h + Linezolid 600 mg\u002F12h.\n   3. Amoxicillin 1 g\u002F6h + Rifampin 600 mg\u002F12h.\n   4. Linezolid 600 mg\u002F12h + Moxifloxacin 400mg\u002F24h.\n   5. Linezolid 600 mg\u002F12h + Rifampin 600 mg\u002F12h. The duration of treatment will be 42 days",[19],"Drug: Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Ampicillin plus ceftriaxone in continuous infusion","Continuous intravenous antibiotic infusion during 42 days for Infective Endocarditis",[9],[27],"Experimental regimen",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed","Ampicillin plus ceftriaxone as an intermittent infusion for a minimum of 14 days. After, if the patient is discharged from the hospital, the following treatments, until the 42-day treatment period is completed:\n\n1. Intravenous treatment according to the following regimens:\n\n   Ampicillin plus ceftriaxone as an intermittent infusion, teicoplanin, daptomycin, dalbavancin or linezolid.\n2. Oral treatment according to the following regimens: amoxicillin plus moxifloxacin, amoxicillin plus linezolid, amoxicillin plus rifampin, linezolid plus moxifloxacin or linezolid plus rifampin.",[15],[33],"Control regimen",[35],{"name":36,"affiliation":37,"role":38},"HUVR Cesar Arístides de Alarcón González, MD-PhD","Fundación para la Gestión de la Investigación en Salud de Sevilla","PRINCIPAL_INVESTIGATOR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Laura Herrera Hidalgo, MD-PhD","CONTACT","+34955013414",null,"lauraherrerahidalgo@gmail.com",{"name":47,"role":42,"phone":43,"phoneExt":44,"email":48},"Clara M Rosso Fernández, MD-PhD","claram.rosso.sspa@juntadeandalucia.es",[50,67,77,91,101,110,119,128,137,147,157,163,172,177,190,205,214,225],{"facility":51,"status":52,"city":53,"state":44,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Hospital Universitario de Álava","RECRUITING","Alava","01009","Spain","ES",{"type":58,"coordinates":59},"Point",[60,61],-6.19946,43.36057,{"lat":61,"lon":60},[64],{"name":65,"role":42,"phone":44,"phoneExt":44,"email":66},"Juan Carlos Gainzarain, MD","juancarlos.gainzarainarana@osakidetza.eus",{"facility":68,"status":69,"city":70,"state":44,"zip":71,"country":55,"countryCode":56,"cosmosGeoPoint":72,"geoPoint":76,"contacts":44},"Hospital Universitario de Cruces","ACTIVE_NOT_RECRUITING","Barakaldo","48903",{"type":58,"coordinates":73},[74,75],-2.98813,43.29639,{"lat":75,"lon":74},{"facility":78,"status":79,"city":80,"state":44,"zip":81,"country":55,"countryCode":56,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Hospital Universitario Vall d'Hebron","NOT_YET_RECRUITING","Barcelona","08035",{"type":58,"coordinates":83},[84,85],2.15899,41.38879,{"lat":85,"lon":84},[88],{"name":89,"role":42,"phone":44,"phoneExt":44,"email":90},"Nuria Fernández Hidalgo, MD","nufernan@gmail.com",{"facility":92,"status":79,"city":80,"state":44,"zip":93,"country":55,"countryCode":56,"cosmosGeoPoint":94,"geoPoint":96,"contacts":97},"Hospital Clínico de Barcelona","08036",{"type":58,"coordinates":95},[84,85],{"lat":85,"lon":84},[98],{"name":99,"role":42,"phone":44,"phoneExt":44,"email":100},"Guillermo Cuervo Requena, MD","glcuervo@clinic.cat",{"facility":102,"status":69,"city":103,"state":44,"zip":104,"country":55,"countryCode":56,"cosmosGeoPoint":105,"geoPoint":109,"contacts":44},"Hospital Universitario de Donostia","Donostia \u002F San Sebastian","20014",{"type":58,"coordinates":106},[107,108],-1.97499,43.31283,{"lat":108,"lon":107},{"facility":111,"status":69,"city":112,"state":44,"zip":113,"country":55,"countryCode":56,"cosmosGeoPoint":114,"geoPoint":118,"contacts":44},"Hospital Universitario Virgen de las Nieves","Granada","18014",{"type":58,"coordinates":115},[116,117],-3.60667,37.18817,{"lat":117,"lon":116},{"facility":120,"status":69,"city":121,"state":44,"zip":122,"country":55,"countryCode":56,"cosmosGeoPoint":123,"geoPoint":127,"contacts":44},"Hospital San Pedro","Logroño","26006",{"type":58,"coordinates":124},[125,126],-2.45115,42.46615,{"lat":126,"lon":125},{"facility":129,"status":69,"city":130,"state":44,"zip":131,"country":55,"countryCode":56,"cosmosGeoPoint":132,"geoPoint":136,"contacts":44},"Hospital Universitario Gregorio Marañón","Madrid","28007",{"type":58,"coordinates":133},[134,135],-3.70256,40.4165,{"lat":135,"lon":134},{"facility":138,"status":79,"city":130,"state":44,"zip":139,"country":55,"countryCode":56,"cosmosGeoPoint":140,"geoPoint":142,"contacts":143},"Hospital Clínico San Carlos","28040",{"type":58,"coordinates":141},[134,135],{"lat":135,"lon":134},[144],{"name":145,"role":42,"phone":44,"phoneExt":44,"email":146},"Ana Muñoz Gómez, MD","amg.sevilla@gmail.com",{"facility":148,"status":79,"city":130,"state":44,"zip":149,"country":55,"countryCode":56,"cosmosGeoPoint":150,"geoPoint":152,"contacts":153},"Hospital Universitario La Paz","28046",{"type":58,"coordinates":151},[134,135],{"lat":135,"lon":134},[154],{"name":155,"role":42,"phone":44,"phoneExt":44,"email":156},"Belén Loeches, MD","bloeches@yahoo.es",{"facility":158,"status":69,"city":130,"state":44,"zip":159,"country":55,"countryCode":56,"cosmosGeoPoint":160,"geoPoint":162,"contacts":44},"Hospital Universitario Puerta del Hierro","28222",{"type":58,"coordinates":161},[134,135],{"lat":135,"lon":134},{"facility":164,"status":69,"city":165,"state":44,"zip":166,"country":55,"countryCode":56,"cosmosGeoPoint":167,"geoPoint":171,"contacts":44},"Hospital Universitario Regional de Málaga","Málaga","29010",{"type":58,"coordinates":168},[169,170],-4.42034,36.72016,{"lat":170,"lon":169},{"facility":173,"status":69,"city":165,"state":44,"zip":166,"country":55,"countryCode":56,"cosmosGeoPoint":174,"geoPoint":176,"contacts":44},"Hospital Universitario Virgen de la Victoria",{"type":58,"coordinates":175},[169,170],{"lat":170,"lon":169},{"facility":178,"status":52,"city":179,"state":44,"zip":180,"country":55,"countryCode":56,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Hospital Universitario de Canarias","San Cristóbal de La Laguna","38320",{"type":58,"coordinates":182},[183,184],-16.32014,28.4853,{"lat":184,"lon":183},[187],{"name":188,"role":42,"phone":44,"phoneExt":44,"email":189},"Remedios Alemán, MD","remealeman@hotmail.com",{"facility":191,"status":52,"city":192,"state":44,"zip":193,"country":55,"countryCode":56,"cosmosGeoPoint":194,"geoPoint":198,"contacts":199},"Hospital Universitario Marqués de Valdecilla","Santander","39008",{"type":58,"coordinates":195},[196,197],-3.80493,43.46589,{"lat":197,"lon":196},[200,203],{"name":201,"role":42,"phone":44,"phoneExt":44,"email":202},"Mª Carmen Fariñas, MD","mcarmen.farinas@scsalud.es",{"name":204,"role":42,"phone":44,"phoneExt":44,"email":44},"MD",{"facility":206,"status":69,"city":207,"state":44,"zip":208,"country":55,"countryCode":56,"cosmosGeoPoint":209,"geoPoint":213,"contacts":44},"Hospital Universitario Virgen Macarena","Seville","41009",{"type":58,"coordinates":210},[211,212],-5.97317,37.38283,{"lat":212,"lon":211},{"facility":215,"status":52,"city":207,"state":44,"zip":216,"country":55,"countryCode":56,"cosmosGeoPoint":217,"geoPoint":219,"contacts":220},"Hospital Universitario Virgen del Rocío","41013",{"type":58,"coordinates":218},[211,212],{"lat":212,"lon":211},[221],{"name":222,"role":42,"phone":223,"phoneExt":44,"email":224},"Cesar Aristides de Alarcon gonzalez, MD","+34 955 013414","aa2406ge@yahoo.es",{"facility":226,"status":69,"city":227,"state":44,"zip":228,"country":55,"countryCode":56,"cosmosGeoPoint":229,"geoPoint":233,"contacts":44},"Hospital Universitari MútuaTerrassa","Terrassa","08221",{"type":58,"coordinates":230},[231,232],2.01667,41.56667,{"lat":232,"lon":231},{"type":235,"investigatorFullName":44,"investigatorTitle":44,"investigatorAffiliation":44,"oldNameTitle":44,"oldOrganization":44},"SPONSOR",[237],{"name":238,"class":239},"Spanish Clinical Research Network - SCReN","NETWORK","100548661","phase-4-ampicillin-and-ceftriaxone-for-the-treatment-of-enterococcus-faecalis-infective-endocarditis-100548661",false,"NCT06423898","Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.","Efficacy and Safety of Ampicillin and Ceftriaxone Continuous Infusion Versus Standard Therapy for the Treatment of Enterococcus Faecalis Infective Endocarditis (DOβLEI Study)","DOBLEI","Inclusion Criteria:\n\n* Adult patients\n* Possible or definitive diagnosis of infective endocarditis due to Enterococcus faecalis\n* Signed informed consent of patients\n\nExclusion Criteria:\n\n* Allergy to penicillins or cephalosporins\n* Pregnancy and lactation\n* Polymicrobial infection including microorganisms different to E. faecalis","ALL","18 Years",{"count":251,"type":252},284,"ESTIMATED","INTERVENTIONAL",[255],"PHASE4","Phase IV, open-label, randomized and multicenter clinical trial to prove that patients with Enterococcus faecalis infective endocarditis treated with an antibiotic treatment as a continuous infusion is non-inferior to the standard treatment, usually administered in hospitalized patients.",[258],"Endocarditis, Infective",[258,260,261,262,263],"Enterococcus faecalis","Antibiotics","Outpatient Infusion Therapies","Outpatient Care","2025-07-24",{"date":266,"type":267},"2025-07-25","ACTUAL",{"date":269,"type":267},"2024-10-09",{"date":271,"type":252},"2028-12-31",{"name":5,"class":6},18]