[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548532":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":62,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":12,"eligibilityCriteria":73,"healthyVolunteers":70,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":12,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":12,"overallStatus":87,"whyStopped":12,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Santiago de Compostela","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"No Intervention","NO_INTERVENTION","Receiving no prophylaxis",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Clindamycin","ACTIVE_COMPARATOR","Receiving 600 mg oral Clindamycin 1 hour before general anesthesia and before any dental manipulation",[18],"Drug: Clindamycin",{"label":20,"type":15,"description":21,"interventionNames":22},"Doxycycline","Receiving 100 mg oral Doxycycline 1 hour before general anesthesia and before any dental manipulation",[23],"Drug: Doxycycline",[25,28],{"type":26,"name":14,"description":16,"armGroupLabels":27,"otherNames":12},"DRUG",[14],{"type":26,"name":20,"description":21,"armGroupLabels":29,"otherNames":12},[20],[31],{"name":32,"affiliation":33,"role":34},"Pedro Diz Dios","Santiago de Compostela University","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":12,"email":40},"JAVIER Feijoo","CONTACT","+34636962202","javier.fernandez@usc.es",{"name":32,"role":38,"phone":42,"phoneExt":12,"email":43},"+34617864293","pedro.diz@usc.es",[45],{"facility":46,"status":12,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Santiago de Compostela University Hospital","Santiago de Compostela","A Coruña","15782","Spain","ES",{"type":53,"coordinates":54},"Point",[55,56],-8.54569,42.88052,{"lat":56,"lon":55},[59,61],{"name":60,"role":38,"phone":12,"phoneExt":12,"email":40},"Javier Fernandez Feijoo",{"name":32,"role":38,"phone":12,"phoneExt":12,"email":43},{"type":34,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Pedro DIz DIos","Full Professor",[66],{"name":67,"class":6},"Hospital Clinico Universitario de Santiago","100548532","phase-4-an-oral-doxycycline-regimen-to-prevent-bacteremia-following-dental-procedures-100548532",false,"NCT06422221","An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures","Inclusion Criteria:\n\n* Subjects must have at least 10 teeth.\n* Subjects must have the need for a dental extraction under general anesthesia (for behavioral reasons).\n* Subjects will be recruited regardless of the extent and severity of their dental and\u002For periodontal disease.\n\nExclusion Criteria:\n\n* Age under 18 years\n* Body weight under 40 kg\n* Receipt of antibiotics in the previous 3 months\n* Routine use of oral antiseptics\n* A history of allergy or intolerance to doxycycline\n* A history of allergy or intolerance to cindamycin\n* Any type of congenital or acquired immunodeficiency\n* Any known risk factor for bacterial endocarditis\n* Any known risk factor for prolonged bleeding","ALL","18 Years","65 Years",{"count":78,"type":79},150,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. The last American Heart Association (AHA) and European Society of Cardiology (ESC) guidelines include several important changes, highlighting that clindamycin (CLI) is no longer recommended as an alternative to amoxicillin in those allergic to penicillin. This new project aims to evaluate the effectiveness of oral doxycycline in preventing post-dental extraction bloodstream infection.",[85,86],"Bacteremia","Endocarditis","NOT_YET_RECRUITING","2024-06-13",{"date":90,"type":91},"2024-06-17","ACTUAL",{"date":93,"type":79},"2024-07-15",{"date":95,"type":79},"2025-06-30",{"name":5,"class":6},1]