[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541451":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":63,"collaborators":65,"id":109,"slug":110,"hasResults":111,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":111,"sex":117,"minAge":118,"maxAge":44,"enrollmentInfo":119,"targetDuration":44,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":130,"overallStatus":48,"whyStopped":44,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"Samsung Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TIVA group","EXPERIMENTAL","The TIVA group will receive propofol for both induction and maintenance of general anesthesia.",[13],"Drug: Propofol",{"label":15,"type":16,"description":17,"interventionNames":18},"GAS group","ACTIVE_COMPARATOR","The GAS group will receive one or more volatile anesthetics (sevoflurane, desflurane, or isoflurane) for induction and maintenance of anesthesia during the surgery. For GAS group, propofol, midazolam, remimazolam, etomidate, or ketamine can be used with inhalation agents as co-induction agents under the discretion of the attending anesthesiologist.",[19],"Drug: Inhaled anesthetics",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Propofol","Propofol will be used for the induction and maintenance of general anesthesia.",[9],[27],"Propofol 1% or 2% inj.",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Inhaled anesthetics","Inhaled anesthetics will be used for the maintenance of general anesthesia.",[15],[33],"Sevoflurane, Desflurane, Isoflurane",[35],{"name":36,"affiliation":37,"role":38},"Hyun Joo Ahn","Department of Anesthesiology and Pain Medicine, Samsung Medical Center","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Jeayoun Kim, MD","CONTACT","8234106590",null,"jeayoun.kim@samsung.com",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":44,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Seoul","Seoul-teukbyeolsi","06351","South Korea",{"type":54,"coordinates":55},"Point",[56,57],126.9784,37.566,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":62,"phoneExt":44,"email":45},"Jeayoun Kim, MD, PhD","821039268786",{"type":38,"investigatorFullName":36,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Professor",[66,68,70,72,74,76,78,80,82,84,86,88,90,92,94,96,98,100,102,104,107],{"name":67,"class":6},"Seoul National University Hospital",{"name":69,"class":6},"Asan Medical Center",{"name":71,"class":6},"Severance Hospital",{"name":73,"class":6},"Seoul St. Mary's Hospital",{"name":75,"class":6},"Korea University Guro Hospital",{"name":77,"class":6},"DongGuk University",{"name":79,"class":6},"Inha University Hospital",{"name":81,"class":6},"Konkuk University Medical Center",{"name":83,"class":6},"Ewha Womans University",{"name":85,"class":6},"Chungnam National University Hospital",{"name":87,"class":6},"University of Virginia",{"name":89,"class":6},"Memorial Sloan Kettering Cancer Center",{"name":91,"class":6},"Yale University",{"name":93,"class":6},"Mayo Clinic",{"name":95,"class":6},"University of Texas Southwestern Medical Center",{"name":97,"class":6},"University Hospitals Coventry and Warwickshire NHS Trust",{"name":99,"class":6},"Khon Kaen University",{"name":101,"class":6},"King Chulalongkorn Memorial Hospital",{"name":103,"class":6},"The Affiliated Hospital of Qingdao University",{"name":105,"class":106},"Beijing Hospital","OTHER_GOV",{"name":108,"class":6},"All India Institute of Medical Sciences","100541451","phase-4-anesthesia-and-non-small-cell-lung-cancer-recurrence-100541451",false,"NCT06330038","Anesthesia and Non-small Cell Lung Cancer Recurrence","Recurrence Free Survival After Curative Resection of Non-small Cell Lung Cancer Between Inhalational Gas Anesthesia and Propofol-based Total IntraVenous Anesthesia: a Multicenter, Randomized, Clinical Trial","GASTIVA","Inclusion Criteria:\n\n* American Society of Anesthesiologists physical status (ASA) Ⅰ-Ⅲ\n* The Eastern Cooperative Oncology Group (ECOG) performance status 0-2\n* Lung resection surgery (segmentectomy, lobectomy, bilobectomy, pneumonectomy; video-assisted, robot-assisted, or open) with curative intent for NSCLC (clinical Tumor, Node, Metastasis (TNM) stage Ⅰ- ⅢA).\n\nExclusion Criteria:\n\n* Distant metastasis or malignant tumor in other organs that according to the attending surgeon is not in long-term remission\n* Severe neurologic conditions\n* Severe hepatic disease (Child-Pugh classification C)\n* Renal failure requiring renal replacement therapy\n* History of anesthesia and\u002For surgery within 1 yr\n* Previous surgery due to lung cancer (except diagnostic biopsies)\n* Contraindications to any study medication (history of allergy, hypersensitivity reaction, or any other contraindication)\n* Planned joint extrapulmonary procedure\n* Surgery under cardiopulmonary bypass or extracorporeal membrane oxygenation\n* Postoperative sedation\n* Pregnancy, or lactation\n* Patient refusal.","ALL","19 Years",{"count":120,"type":121},5384,"ESTIMATED","INTERVENTIONAL",[124],"PHASE4","There has been ongoing debate about the relationship between cancer recurrence and anesthetic management. Therefore, the investigators will test the hypothesis that the recurrence free survival (RFS) after curative resection of NSCLC is higher in patient who received total intravenous anesthesia (TIVA) than volatile anesthetics in this multi-center randomized trials.",[127,128,129],"Non-small Cell Lung Cancer","Surgery","Anesthesia",[129,131,132,133,134,135,23,136,137,128,138],"Desflurane","Inhalational anesthesia","Isoflurane","Lung neoplasm","Metastasis","Recurrence","Sevoflurane","Non-small cell lung cancer","2026-04-15",{"date":141,"type":142},"2026-04-20","ACTUAL",{"date":144,"type":142},"2024-08-05",{"date":146,"type":121},"2028-12-31",{"name":5,"class":6},1]