[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629826":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":41,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":41,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":41,"enrollmentInfo":75,"targetDuration":41,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":92,"whyStopped":41,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Light anesthesia","EXPERIMENTAL","Anesthesia will be maintained by target-controlled infusion of propofol and remifentanil at a fix ratio; the target BIS is 50.",[13],"Drug: Light anesthesia",{"label":15,"type":16,"description":17,"interventionNames":18},"Deep anesthesia","ACTIVE_COMPARATOR","Anesthesia will be maintained by target-controlled infusion of propofol and remifentanil at a fix ratio; the target BIS is 35.",[19],"Drug: Deep anesthesia",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Anesthesia will be maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio; the target BIS is 50.",[9],[26],"Light anesthesia with propofol and remifentanil",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Anesthesia will be maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio; the target BIS is 35.",[15],[31],"Deep anesthesia with propofol and remifentanil",[33],{"name":34,"affiliation":5,"role":35},"Dong-Xin Wang","PRINCIPAL_INVESTIGATOR",[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Dong-Xin Wang, MD, PhD","CONTACT","010-83575138",null,"wangdongxin@hotmail.com",{"name":44,"role":39,"phone":41,"phoneExt":41,"email":45},"Ding Ting, MD","dingting01@bjmu.edu.cn",[47],{"facility":5,"status":41,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Beijing","Beijing Municipality","100034","China","CN",{"type":54,"coordinates":55},"Point",[56,57],116.39723,39.9075,{"lat":57,"lon":56},[60,62],{"name":38,"role":39,"phone":61,"phoneExt":41,"email":42},"010-83572784",{"name":63,"role":39,"phone":40,"phoneExt":41,"email":45},"Ting Ding, MD",{"type":35,"investigatorFullName":34,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Chief Physician, Professor","100629826","phase-4-anesthesia-maintenance-with-target-controlled-infusion-of-propofol-and-remifentanil-at-fixed-ratio-100629826",false,"NCT07479719","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio","Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio on Neurocognitive Recovery in Older Patients After Surgery: a Randomized Trial","Inclusion Criteria:\n\n1. Aged ≥ 65 years.\n2. Scheduled to undergo noncardiac surgery expected to last ≥ 1 hour under general anesthesia.\n3. Require patient-controlled intravenous analgesia after surgery.\n4. Provide written informed consent.\n\nExclusion Criteria:\n\n1. Inability to communicate in the preoperative period because of coma, profound dementia, language barrier, or other reasons.\n2. Previous history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis.\n3. Traumatic brain injury or neurosurgery.\n4. Severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m2), or critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV).\n5. Planned ICU admission with endotracheal intubation after surgery.\n6. Enrolled in the other studies.\n7. Other reasons that are considered unsuitable for study participation by the responsible surgeons or investigators.","ALL","65 Years",{"count":76,"type":77},200,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","The impact of anesthesia depths on early postoperative neurocognitive complications after total intravenous anesthesia (TIVA) remains controversial. In some studies investigating TIVA, anesthesiologists mainly achieve the target depth of anesthesia by adjusting the dose of propofol, whereas the doses of opioids remains comparable between different anesthetic depth groups, possibly resulting inadequate analgesia. This study is aimed to investigate the impact of different anesthesia depths maintained by target-controlled infusion of propofol and remifentanil at a fixed ratio on the incidence of early postoperative neurocognitive complications in older patients undergoing noncardiac surgery.",[83,84,85,86,87],"Elderly","Surgery","Depth of Anesthesia","Total Intravenous Anesthesia","Delayed Neurocognitive Recovery",[83,84,89,90,91],"Depth of anesthesia","Total intravenous anesthesia","Delayed neurocognitive recovery","NOT_YET_RECRUITING","2026-03-15",{"date":95,"type":96},"2026-03-18","ACTUAL",{"date":98,"type":77},"2026-04",{"date":100,"type":77},"2027-01",{"name":5,"class":6},1]