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Winterthur","Winterthur","8400",{"type":52,"coordinates":1285},[1286,1287],8.72413,47.50564,{"lat":1287,"lon":1286},[1290],{"name":1291,"role":32,"phone":18,"phoneExt":18,"email":18},"Michael Osthoff, MD",{"facility":1293,"status":45,"city":211,"state":18,"zip":1294,"country":1295,"countryCode":1296,"cosmosGeoPoint":1297,"geoPoint":1301,"contacts":1302},"Liverpool Heart and Chest Hospital","L14 3PE","United Kingdom","UK",{"type":52,"coordinates":1298},[1299,1300],-2.97794,53.41058,{"lat":1300,"lon":1299},[1303],{"name":1304,"role":32,"phone":18,"phoneExt":18,"email":18},"Michael Shackcloth, MD",{"facility":1306,"status":45,"city":1307,"state":18,"zip":1308,"country":1295,"countryCode":1296,"cosmosGeoPoint":1309,"geoPoint":1313,"contacts":1314},"Southend Hospital","Westcliff-on-Sea","SS0 0RY",{"type":52,"coordinates":1310},[1311,1312],0.69179,51.54424,{"lat":1312,"lon":1311},[1315],{"name":1316,"role":32,"phone":18,"phoneExt":18,"email":18},"James Jegard, MD",{"type":1318,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[1320],{"name":1321,"class":6},"Hamilton Health Sciences Corporation","100360075","phase-4-anticoagulation-for-stroke-prevention-in-patients-with-recent-episodes-of-atrial-fibrillation-occurring-transiently-with-stress-100360075",false,"NCT03968393","Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress","Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress - The ASPIRE-AF Trial","ASPIRE-AF","Inclusion Criteria:\n\n1. have ≥1 episode of clinically important AFOTS during any of the following conditions:\n\n   1. noncardiac surgery in the past 35 days, with at least an overnight hospital admission aftersurgery;\n   2. noncardiac day surgery resulting in a large enough physiological insult to be able to cause AFOTS, as judged by the local investigator; or\n   3. acute medical illness requiring hospital admission in the past 35 days and resulting in a large enough physiological insult to be able to cause AFOTS, as judged by the local investigator;\n2. sinus rhythm at the time of randomization;\n3. any of the following high-risk criteria:\n\n   1. age 55-64 years, and having either known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score ≥3, or an elevated postoperative troponin level;\n   2. age 65-74 years, and having either known cardiovascular disease, recent major vascular surgery, a CHA2DS2VASc score ≥2, or an elevated postoperative troponin level; OR\n   3. age ≥75 years.;\n4. provide written informed consent\n\nExclusion Criteria:\n\n1. any cardiac diagnosis as the primary reason for hospital admission;\n2. history of documented chronic AF prior to noncardiac surgery;\n3. need for long-term systemic anticoagulation;\n4. ongoing need for long-term dual antiplatelet treatment;\n5. contraindication to oral anticoagulation;\n6. severe renal insufficiency (CrCl \\\u003C20 ml\u002Fmin);\n7. severe liver cirrhosis (i.e., Child-Pugh Class C)\n8. acute stroke in the past 14 days;\n9. underwent cardiac surgery in the past 35 days;\n10. history of nontraumatic intracranial, intraocular, or spinal bleeding;\n11. hemorrhagic disorder or bleeding diathesis;\n12. expected to be non-compliant with follow-up and\u002For study medications;\n13. known life expectancy less than 1 year due to concomitant disease;\n14. women who are pregnant, breastfeeding, or of childbearing potential who are not taking effective contraception; OR\n15. previously enrolled in the trial","ALL","55 Years",{"count":1333,"type":1334},2270,"ESTIMATED","INTERVENTIONAL",[1337],"PHASE4","Multinational, investigator-initiated study of oral anticoagulation versus no anticoagulation for the prevention of stroke and other adverse cardiovascular events in patients with transient atrial fibrillation occurring transiently with stress and additional stroke risk factors.",[1340,1341],"Stroke","Atrial Fibrillation",[1343,1344,1345,1346,1347,1348,1349],"Transient Atrial Fibrillation","Perioperative Atrial Fibrillation","Non-vitamin K Oral Anticoagulation","Noncardiac Surgery","PROBE Design","Medical Illness","Stress","2026-01-08",{"date":1352,"type":1353},"2026-01-12","ACTUAL",{"date":1355,"type":1353},"2019-06-14",{"date":1357,"type":1334},"2028-12",{"name":5,"class":6},105]