[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100389173":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":38,"responsibleParty":58,"collaborators":36,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":36,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":41,"whyStopped":36,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Penza State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Atorvastatin 80 mg","EXPERIMENTAL","Treatment with atorvastatin is prescribed at a dose of 80 mg \u002F day from the first 24-96 hours of AMI in addition to the standard therapy.\n\nIf there is no achievement of the target level of LDL-C, ≤1.5 mmol \u002F L after 5-6 weeks from the AMI onset, patients additionally receive ezetimibe at a dose of 10 mg 1 time \u002F day.",[13],"Drug: Atorvastatin 80mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Atorvastatin-Ezetimibe","ACTIVE_COMPARATOR","In the absence of reaching the target level of LDL-C of ≤1.4 mmol \u002F L and a decrease in the indicator by ≥50% after 5-6 weeks from the onset of AMI, patients additionally receive ezetimibe at a dose of 10 mg 1 time \u002F day.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Atorvastatin 80mg","Atorvastatin is prescribed at a dose of 80 mg \u002F day from the first 24-96 hours of AMI in addition to the standard therapy",[9,15],[26],"Ezetimibe",[28],{"name":29,"affiliation":5,"role":30},"Valentin E Oleynikov, DM","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Nadezhda V Burko, PhD","CONTACT","+78412548229",null,"hopeful.n@mail.ru",[39],{"facility":40,"status":41,"city":42,"state":36,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Valentin Oleynikov","RECRUITING","Penza","440026","Russia","RU",{"type":47,"coordinates":48},"Point",[49,50],45.01075,53.19568,{"lat":50,"lon":49},[53,56],{"name":54,"role":34,"phone":35,"phoneExt":36,"email":55},"Valentin Oleynikov, Prof.","v.oleynikof@gmail.com",{"name":57,"role":34,"phone":35,"phoneExt":36,"email":37},"Nadezhda Burko, PhD",{"type":30,"investigatorFullName":40,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"DM","100389173","phase-4-assessment-of-the-effects-of-long-term-lipid-lowering-therapy-in-patients-with-primary-stemi-or-nstemi-100389173",false,"NCT04347434","Assessment of the Effects of Long-term Lipid-lowering Therapy in Patients With Primary STEMI or NSTEMI","Assessment of the Effects of Long-term Lipid-lowering Therapy on Parameters of Electrical Myocardial Heterogeneity, Myocardial Deformation Characteristics, Vascular Rigidity, and Quality of Life in Patients With Primary STEMI or NSTEMI","CONTRAST-2","Inclusion Criteria:\n\n1\\. Signed Informed Consent Form 2 Primary STEMI or NSTEMI confirmed by ECG, troponin I and CPK-MB levels, coronary angiography.\n\n3\\. Presence of an infarct-related artery according to coronary angiography.\n\nExclusion Criteria:\n\n1. Presence of hemodynamically relevant stenosis exceeding 30% in several coronary arteries confirmed by CAG;\n2. Recurrent or repeated myocardial infarction.\n3. Exogenous hypertriglyceridemia (type 1 hyperchilomicronemia).\n4. The development of acute heart failure III-IV prior to randomization\n5. Individual intolerance to statins, ezetimibe.\n6. Congenital and acquired heart diseases.\n7. Severe concomitant diseases in the stage of decompensation.\n8. Non-sinus rhythm, established artificial pacemaker.\n9. Sinoatrial and atrioventricular blockade of 2-3 degrees.\n10. QRS complex exceeding 100 ms.\n11. The presence of severe LV hypertrophy according to echocardiography.\n12. Uncontrolled hypertension with SBP\\> 180 mm Hg and DBP\\> 110 mmHg\n13. Diabetes mellitus (DM) type 1 and 2.\n14. Current existence of severe anemia (Hb \\\u003C 100 g\u002FL)\n15. Chronic kidney disease (creatinine clearance less than 30 ml \u002F min \u002F 1.73 m2 according to the CKD-EPI).\n16. Non-corrected thyroid dysfunction with hyper \u002F hypothyroidism.\n17. Body mass index (BMI) ≥35 kg \u002F m2.\n18. Pregnancy, lactation.\n19. Alcohol abuse, drug addiction.\n20. Other serious concomitant diseases that exclude the possibility of study participation.\n21. Participation in other clinical trials within the last two months.","ALL","30 Years","70 Years",{"count":72,"type":73},300,"ESTIMATED","INTERVENTIONAL",[76],"PHASE4","In a single-center, open-label, prospective, controlled, clinical study, it is planned to include 300 patients hospitalized in the cardiology department of SBHI Penza regional clinical hospital n.a. N.N. Burdenko. Recruitment of patients will be carried out at the Department of Therapy of the Medical Institute of the Penza State University. Patients meeting the inclusion criteria and not meeting the exclusion criteria will be included in the study.\n\nInitially, lipid-lowering treatment with atorvastatin is prescribed at a dose of 80 mg \u002F day from the first 24-96 hours of AMI in addition to the standard therapy.\n\nIf there is no achievement of the target level of LDL-C, ≤1.5 mmol \u002F L after 5-6 weeks from the AMI onset, patients additionally receive ezetimibe at a dose of 10 mg 1 time \u002F day.\n\nStandard AMI treatment includes dual antiplatelet therapy, ACE inhibitors, beta-blockers (if indicated). Prescription of proton pump inhibitors and nitrates is possible (if indicated).\n\nThe total follow-up is 96 weeks. Prescreening - 600 people; screening and randomization - 300 people. Parameters of electrical myocardial heterogeneity, myocardial deformation characteristics, vascular rigidity, and quality of life will be assessed according to the study plan.",[79,80,81,82],"Myocardial Infarction, Acute","Myocardial Strain","Arterial Stiffness","Quality of Life",[84,85,86,87,88,89],"STEMI","NSTEMI","myocardial strain,","arterial stiffness,","lipid-lowering therapy,","electrical myocardial heterogeneity","2023-11-22",{"date":92,"type":93},"2023-11-24","ACTUAL",{"date":95,"type":93},"2020-02-12",{"date":97,"type":73},"2027-12-30",{"name":5,"class":6},1]