[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625654":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":11,"responsibleParty":39,"collaborators":11,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":11,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":11,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":64,"whyStopped":11,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":11},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine Group","EXPERIMENTAL",null,[13],"Drug: Dexmedetomidine",{"label":15,"type":16,"description":11,"interventionNames":17},"Fentanyl-Midazolam Group","ACTIVE_COMPARATOR",[18],"Drug: Fentanyl- midazolam",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DRUG","Dexmedetomidine","investigator will give Loading dose 1 mcg\u002Fkg IV over 10 min, followed by infusion 0.5 mcg\u002Fkg\u002Fh until pneumoperitoneum established",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Fentanyl- midazolam","Investigator will inject Fentanyl 2 mcg\u002Fkg IV + Midazolam 0.05 mg\u002Fkg IV before induction.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Anas Ahmed Abd elmoaty, resident doctor","CONTACT","+201006318654","anasa1@yahoo.com",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"Obey mohamed elhassan Shaker Osman, prof","+201143311373","Obeywafa@hotmail.com",{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Anas Ahmed Abd Elmoaty","doctor","100625654","phase-4-attenuate-the-stress-response-in-laparoscopic-cholecystectomy-100625654",false,"NCT07425444","Attenuate the Stress Response in Laparoscopic Cholecystectomy","Dexmedetomidine Versus Fentanyl-Midazolam Combination to Attenuate the Stress Response in Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Age 18-65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I - II.\n\nExclusion Criteria:\n\n* Known allergy to study drugs.\n* Uncontrolled, non-correctable comorbidities (hepatic, renal or cardiac such as hypertension \\& Arrhythmia ).\n* History of psychiatric illness or substance abuse.\n* Pregnancy or lactation","ALL","18 Years","65 Years",{"count":54,"type":55},50,"ESTIMATED","INTERVENTIONAL",[58],"PHASE4","Aims of this study are to compare the effectiveness of dexmedetomidine versus fentanyl-midazolam in attenuating hemodynamic stress response during laparoscopic cholecystectomy (mainly HR). And to assess the recovery profile, the pain and opioid requirements, the sedation profile, and any adverse events during the first 24 hrs postoperatively",[61],"Laparoscopic Cholecystectomy Surgery",[63],"stress response","NOT_YET_RECRUITING","2026-02-19",{"date":67,"type":68},"2026-02-20","ACTUAL",{"date":70,"type":55},"2026-02",{"date":72,"type":55},"2027-04",{"name":5,"class":6}]