[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592845":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":19,"responsibleParty":26,"collaborators":19,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":32,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":19,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":50,"overallStatus":55,"whyStopped":19,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":19},{"fullName":5,"class":6},"Sir Run Run Shaw Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"remimazolam group","EXPERIMENTAL","Measurement of ED95 in uremic patients sedated with remimazolam using the BCD method",[13],"Drug: remimazolam sedation",[15],{"type":16,"name":17,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","remimazolam sedation",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Jie Zhao","CONTACT","8615068829652","zhaojie1014@zju.edu.cn",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Gang Chen","chief physician","100592845","phase-4-bcd-to-measure-the-ed95-of-remimazolam-assisted-sedation-in-arteriovenous-fistula-creation-surgery-100592845",false,"NCT06998732","BCD to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery","Using Biased Coin Design (BCD) to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery","BCD","Inclusion Criteria:\n\n* 18-65 years old (including borderline values).\n* Elective surgical patients under local anaesthesia for operation of AVF\n* Voluntary participation in this study and signing of informed consent.\n* American Society of Anesthesiologists (ASA) classification \\\u003C Grade IV.\n* BMI range: 18-28kg\u002Fm2 (including borderline values).\n\nExclusion Criteria:\n\n* hypersensitivity to remimazolam or benzodiazepines.\n* patients with severe cardiac, pulmonary, neurological diseases or liver failure. -- Preoperative use of sedative drugs, anticonvulsants, etc.\n* patients who cannot cooperate with postoperative recovery or follow-up.\n* vulnerable groups, including those with mental illness, cognitive impairment, critically ill patients, pregnant women, illiterates, etc.","ALL","18 Years","65 Years",{"count":42,"type":43},40,"ESTIMATED","INTERVENTIONAL",[46],"PHASE4","This study intends to measure the ED95 of remimazolam-assisted sedation in arteriovenous fistula creation by BCD.",[49],"Uremia",[51,52,53,54],"Biased Coin Design","uremia","remimazolam","ED95","NOT_YET_RECRUITING","2025-05-22",{"date":58,"type":59},"2025-05-31","ACTUAL",{"date":61,"type":43},"2025-06-01",{"date":63,"type":43},"2025-10-31",{"name":28,"class":6}]