[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574990":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":12,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":53,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":12,"enrollmentInfo":67,"targetDuration":12,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":34,"whyStopped":12,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Erasmus Medical Center","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","This arm will receive standard of care according to local protocol.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention","EXPERIMENTAL","This arm will be treated with double dosages of beta-lactam antibiotics the first 48 hours after inclusion.",[18],"Drug: Double dosing of beta-lactam antibiotic",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DRUG","Double dosing of beta-lactam antibiotic","This arm will receive double dosing of beta-lactam antibiotics for the first 48 hours after inclusion.",[14],[26],{"name":27,"role":28,"phone":29,"phoneExt":12,"email":30},"Birgit C.P. Koch, PharmD","CONTACT","0031107033202","b.koch@erasmusmc.nl",[32],{"facility":33,"status":34,"city":35,"state":12,"zip":12,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Maasstad Ziekenhuis","RECRUITING","Rotterdam","Netherlands","NL",{"type":39,"coordinates":40},"Point",[41,42],4.47917,51.9225,{"lat":42,"lon":41},[45],{"name":46,"role":28,"phone":47,"phoneExt":12,"email":48},"Dr. Den Uil","0031102913474","uilc@maasstadziekenhuis.nl",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"PRINCIPAL_INVESTIGATOR","Birgit Koch","Principal Investigator",[54,56],{"name":55,"class":6},"Maasstad Hospital",{"name":57,"class":6},"Albert Schweitzer Hospital","100574990","phase-4-beta-lactam-antibiotics-initial-exposure-optimised-in-critically-ill-patients-with-sepsis-100574990",false,"NCT06766461","Beta-Lactam Antibiotics InitiaL ExpoSure OptimisEd in CriticallY Ill Patients with SEpsis","BULLSEYE","Inclusion Criteria:\n\n* ≥18 years of age\n* Receiving intravenous antibiotic therapy of the target drugs (including continuous infusion of beta-lactam antibiotics)\n* Primary infection\n* Admitted to the ICU\n* Meeting the Sepsis-3 criteria for septic shock: sepsis in addition to shock requiring the start of vasopressors to maintain a mean arterial pressure 65 mmHg or greater, and a serum lac tate level greater than 2.0 mmol\u002FL following \"adequate fluid resuscitation\".\n\nExclusion Criteria:\n\n* Patient or legal representative not available to give informed consent within 72 hours after admittance\n* Pregnancy\n* Admittance for burn wounds\n* Patients receiving target antibiotics only as prophylaxis within the context of Selective Diges tive tract Decontamination (SDD)\n* Enrolment in another interventional trial\n* Patient received the study antibiotic for more than 24 hours before inclusion\n* Patient receiving extracorporeal membrane oxygenation (ECMO)\n* Patient is already treated with a double dose of antibiotics based on suspected infection","ALL","18 Years",{"count":68,"type":69},980,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","The aim of this study is to investigate if an initial short double dose of beta-lactam antibiotics will reduce mortality in critically ill patients with sepsis.",[75,76,77],"Sepsis - to Reduce Mortality in the Intensive Care Unit","Sepsis","Septic Shock",[79,80,81,82,83],"sepsis","intensive care","critically ill","antibiotic","septic shock","2025-01-08",{"date":86,"type":87},"2025-01-09","ACTUAL",{"date":89,"type":87},"2025-01-03",{"date":91,"type":69},"2027-12-01",{"name":5,"class":6},1]