[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532149":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":50,"centralContacts":62,"locations":71,"responsibleParty":92,"collaborators":44,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":44,"eligibilityCriteria":101,"healthyVolunteers":97,"sex":102,"minAge":103,"maxAge":44,"enrollmentInfo":104,"targetDuration":44,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":74,"whyStopped":44,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Assiut University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Gentamicin group","EXPERIMENTAL","This arm will undergo bronchoscopic airway clearance followed by local instillation of gentamicin (80 mg once) and Budesonide (0.5 mg) once.",[13,14],"Drug: Local instillation of gentamicin and Budesonide","Procedure: Bronchoscopic mechanical secretion suction and lavage",{"label":16,"type":10,"description":17,"interventionNames":18},"Levofloxacin group","This arm will undergo bronchoscopic airway clearance followed by bronchoscopic instillation of levofloxacin 480 mg in isotonic saline during standardized bronchoscopy. And Budesonide (0.5 mg) once.",[19,14],"Drug: Local instillation of Levofloxacin and Budesonide",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham group","SHAM_COMPARATOR","Bronchoscopy for airway visualization only, no lavage or drug instillation (sham procedure).",[25],"Procedure: Sham Bronchoscopy",[27,34,40,45],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Local instillation of gentamicin and Budesonide","Bronchoscopic local instillation of gentamicin and Budesonide",[9],[33],"Bronchoscopic instillation of gentamicin and steroids",{"type":28,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Local instillation of Levofloxacin and Budesonide","Bronchoscopic local instillation of Levofloxacin and Budesonide",[16],[39],"Bronchoscopic instillation of levofloxacin and steroids",{"type":41,"name":42,"description":42,"armGroupLabels":43,"otherNames":44},"PROCEDURE","Bronchoscopic mechanical secretion suction and lavage",[9,16],null,{"type":41,"name":46,"description":23,"armGroupLabels":47,"otherNames":48},"Sham Bronchoscopy",[21],[49],"Masking intervention",[51,54,57,60],{"name":52,"affiliation":5,"role":53},"Ali A Ali, MSc","PRINCIPAL_INVESTIGATOR",{"name":55,"affiliation":5,"role":56},"Aliae A Hussien, MD","STUDY_CHAIR",{"name":58,"affiliation":5,"role":59},"Ahmad M Shaddad, MD","STUDY_DIRECTOR",{"name":61,"affiliation":5,"role":59},"Maiada K Hashem, MD",[63,67],{"name":52,"role":64,"phone":65,"phoneExt":44,"email":66},"CONTACT","+2001064756136","aliabuzaid@aun.edu.eg",{"name":68,"role":64,"phone":69,"phoneExt":44,"email":70},"Ahmad M shaddad, MD","+2001111171930","Shaddad_ahmad@aun.edu.eg",[72],{"facility":73,"status":74,"city":75,"state":44,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":84,"contacts":85},"Assiut university hospitals","RECRUITING","Asyut","71515","Egypt","EG",{"type":80,"coordinates":81},"Point",[82,83],31.18368,27.18096,{"lat":83,"lon":82},[86,88,89,90,91],{"name":52,"role":64,"phone":87,"phoneExt":44,"email":66},"01064756136",{"name":58,"role":53,"phone":44,"phoneExt":44,"email":44},{"name":55,"role":53,"phone":44,"phoneExt":44,"email":44},{"name":61,"role":53,"phone":44,"phoneExt":44,"email":44},{"name":52,"role":53,"phone":44,"phoneExt":44,"email":44},{"type":53,"investigatorFullName":93,"investigatorTitle":94,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Ali Abuzaid Ali","Assistant lecturer","100532149","phase-4-bronchoscopic-levofloxacin-gentamicin-or-sham-for-acute-exacerbation-of-bronchiectasis-100532149",false,"NCT06209047","Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis","A Randomized Sham-Controlled Trial of Bronchoscopic Levofloxacin and Gentamicin Versus Sham in Mechanically Ventilated Bronchiectasis: Acute and 1-Year Outcomes","Inclusion Criteria:\n\n* patients with bronchiectasis confirmed by high-resolution CT chest(HRCT)\n* patients with acute exacerbation of bronchiectasis who need antibiotic treatment at the hospital due to exacerbation\n* mechanically ventilated patients in the respiratory ICU\n* Age more than or equal to 18 years\n\nExclusion Criteria:\n\n* patients with active pulmonary tuberculosis\n* patients with allergic bronchopulmonary aspergillosis\n* patients who underwent interventional bronchoscopy for hemoptysis\n* age less than 18 years","ALL","18 Years",{"count":105,"type":106},315,"ESTIMATED","INTERVENTIONAL",[109],"PHASE4","Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis requiring invasive mechanical ventilation. The primary outcome is a ranked composite of in-hospital mortality and time to ventilator liberation. Safety and procedural adverse events are closely monitored.",[112],"Bronchiectasis With Acute Exacerbation",[114,115,116,117,118],"Bronchiectasis","Bronchoscopy","Levofloxacin","Gentamicins","Steroids","2025-07-13",{"date":121,"type":122},"2025-07-17","ACTUAL",{"date":124,"type":122},"2023-10-15",{"date":126,"type":106},"2027-02-01",{"name":5,"class":6},1]