[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559575":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":65,"collaborators":44,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":44,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":48,"whyStopped":44,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Huazhong University of Science and Technology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Liposomal Bupivacaine plus Bupivacaine Intervention","EXPERIMENTAL","Participants in this arm will receive liposomal bupivacaine(LB) plus bupivacaine(B) as a local anesthetic for PENG block under ultrasound guidance. Liposomal bupivacaine plus bupivacaine is being investigated for its analgesic effect in postoperative pain management following hip replacement surgery. This arm aims to evaluate the analgesic efficacy, duration of pain relief, and safety profile of liposomal bupivacaine plus bupivacaine compared to the standard local anesthetic, ropivacaine. Participants in this arm will undergo hip replacement surgery under spinal anesthesia and will be assessed for pain relief, opioid analgesic consumption, and any associated complications at multiple time points within 72 hours after surgery.",[13],"Drug: Liposomal bupivacaine plus bupivacaine",{"label":15,"type":16,"description":17,"interventionNames":18},"Ropivacaine Intervention","ACTIVE_COMPARATOR","Participants in this arm will receive ropivacaine (R) as a local anesthetic for the PENG block under ultrasound guidance. Ropivacaine, a routinely used local anesthetic in clinical practice, is being compared to liposomal bupivacaine plus bupivacaine to assess its analgesic effect in postoperative pain management following hip replacement surgery. This arm aims to evaluate the analgesic efficacy, duration of pain relief, and safety profile of ropivacaine in comparison to the investigational intervention, liposomal bupivacaine. Participants in this arm will undergo hip replacement surgery under spinal anesthesia and will be assessed for pain relief, opioid analgesic consumption, and any associated complications at multiple time points within 72 hours after surgery.",[19],"Drug: Ropivacaine",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Liposomal bupivacaine plus bupivacaine","Liposomal bupivacaine is a prolonged-release formulation of the local anesthetic bupivacaine. This intervention involves the administration of liposomal bupivacaine plus bupivacaine as a local anesthetic for the pericapsular nerve group (PENG) block under ultrasound guidance. Liposomal bupivacaine is being investigated for its analgesic effect in postoperative pain management following hip replacement surgery. This formulation is designed to provide extended pain relief as compared to conventional bupivacaine formulations.",[9],[27],"LB+B",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Ropivacaine","Ropivacaine is a commonly used local anesthetic in clinical practice, and it serves as the active comparator intervention in this study. Participants in the comparator arm will receive ropivacaine as a local anesthetic for the PENG block under ultrasound guidance.",[15],[33],"R",[35],{"name":36,"affiliation":37,"role":38},"Wei Mei, MD","Department of Anesthesiology, Tongji Hospital, Tongji Medical College, HUST","STUDY_DIRECTOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Xijian KE, MD","CONTACT","13429826148",null,"kexijian@hust.edu.cn",[47],{"facility":37,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":55,"coordinates":56},"Point",[57,58],114.26667,30.58333,{"lat":58,"lon":57},[61,63],{"name":62,"role":42,"phone":43,"phoneExt":44,"email":45},"Xijian Ke, MD",{"name":41,"role":64,"phone":44,"phoneExt":44,"email":44},"SUB_INVESTIGATOR",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"PRINCIPAL_INVESTIGATOR","Wei Mei","Clinical Professor","100559575","phase-4-bupivacaine-liposome-plus-bupivacaine-or-ropivacaine-for-pericapsular-nerve-group-block-in-hip-arthroplasty-peng-100559575",false,"NCT06565910","Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG)","Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for PENG Block on Post Operative Pain Management in Patients Undergoing Hip Arthroplasty: a Prospective, Randomized, Single Blind, Active Controlled Study","PENG","Inclusion Criteria:\n\n* American Society of Anesthesiologists(ASA) I\\~II\n* Normal coagulation\n* Clinical diagnosis of hip fracture\n\nExclusion Criteria:\n\n* Presence of severe systemic diseases or ASA grade III or higher\n* Allergy to amide local anesthetics","ALL","18 Years","60 Years",{"count":81,"type":82},60,"ESTIMATED","INTERVENTIONAL",[85],"PHASE4","The goal of this clinical trial is to study the analgesic effect of liposomal bupivacaine plus bupivacaine for Pericapsular Nerve Group (PENG) block in postoperative pain management following hip replacement surgery. It will also assess the safety of liposomal bupivacaine for this purpose. The main questions it aims to answer are:\n\n1. Is liposomal bupivacaine plus bupivacaine superior to ropivacaine in terms of analgesic efficacy, duration of pain relief, opioid consumption, and patient satisfaction?\n2. What medical problems do participants encounter when using liposomal bupivacaine plus bupivacaine for PENG block in postoperative pain management following hip replacement surgery?\n\nResearchers will compare liposomal bupivacaine plus bupivacaine to ropivacaine (a routinely used regional anesthetic in clinical practice) to determine if liposomal bupivacaine plus bupivacaine is more effective for pain management following hip replacement surgery.\n\nParticipants will:\n\n1. Receive liposomal bupivacaine plus bupivacaine or ropivacaine as a regional anesthetic for PENG block under ultrasound guidance.\n2. Undergo hip replacement surgery under spinal anesthesia.\n3. Have pain relief, opioid analgesic consumption, and incidence of complications assessed at multiple time points within 72 hours after surgery.",[88,89,90],"Femoral Neck Fractures","Femur Head Necrosis","Hip Fractures",[92,93,94,95],"Bupivacaine Liposome","PENG block","Hip Arthroplasty","Randomized Controlled Trial","2026-03-11",{"date":98,"type":99},"2026-03-13","ACTUAL",{"date":101,"type":99},"2024-12-04",{"date":103,"type":82},"2026-07-01",{"name":5,"class":6},1]