[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545271":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":42,"centralContacts":46,"locations":53,"responsibleParty":77,"collaborators":71,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":71,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":71,"enrollmentInfo":89,"targetDuration":71,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":71,"overallStatus":56,"whyStopped":71,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Kansas Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","ACTIVE_COMPARATOR","Prior to application of the skin graft, a thin layer of thrombin is sprayed onto the wound base. The skin graft is then applied to the recipient site and fixated in standard fashion.",[13,14],"Drug: Thrombin JMI","Procedure: skin graft",{"label":16,"type":17,"description":18,"interventionNames":19},"Experimental","EXPERIMENTAL","Tranexamic acid solution will be sprayed onto the wound base after excision and prior to skin graft appliance in the same manner as the thrombin spray in the control group",[20,14],"Drug: Tranexamic acid",[22,29,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Tranexamic acid","100mg\u002FmL 10mL vials x2 of injectable tranexamic acid will be filled into a 20 milliliter syringe with a spray tip.",[16],[28],"TXA",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Thrombin JMI","The wound base is then sprayed with a film of Thrombin-JMI",[9],[34],"Thrombin",{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"PROCEDURE","skin graft","Skin is taken from uninjured part of the participant's body and used to surgically cover a wound or injured area with skin that contains the epidermis and a portion of the dermis.",[9,16],[41],"skin graft, STSG, autograft",[43],{"name":44,"affiliation":5,"role":45},"Dhaval Bhavsar, MBBS","PRINCIPAL_INVESTIGATOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":51,"email":52},"Jessica Reynolds, BSN","CONTACT","913-588-5000","0044","jreynolds11@kumc.edu",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"The University of Kansas Health System","RECRUITING","Kansas City","Kansas","66160","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-94.62746,39.11417,{"lat":66,"lon":65},[69,72,75],{"name":48,"role":49,"phone":70,"phoneExt":71,"email":52},"913-588-0044",null,{"name":44,"role":49,"phone":73,"phoneExt":71,"email":74},"913-588-2000","dbhavsar@kumc.edu",{"name":76,"role":45,"phone":71,"phoneExt":71,"email":71},"Dhaval R Bhavsar, MBBS",{"type":45,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":71,"oldOrganization":71},"Dhaval Bhavsar","Associate Professor, Plastic, Burn and Wound Surgery, Director of Research","100545271","phase-4-burn-study--tranexamic-acid-versus-thrombin-in-split-thickness-skin-graft-100545271",false,"NCT06379724","Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft","The Use of Topical Tranexamic Acid Versus Thrombin Spray for the Management of Split Thickness Skin Graft Recipient Site in Burn Management","Inclusion Criteria:\n\n* English or Spanish speaking\n* Flame or scald burn injury\n* \\\u003C=10% total body surface area (TBSA) partial thickness\n* \\\u003C= 5% total body surface area (TBSA) deep partial or full thickness\n* Skin graft harvested at 1\u002F12 inch depth, meshed 1:1 or pie crusted if the area is a small functional area\n\nExclusion Criteria:\n\n* \\>10% total body surface area (TBSA) partial thickness burn\n* \\>5% total body surface area (TBSA )surgical area of burn injury (deep partial or full thickness injury)\n* Traumatic or chemical burn mechanism\n* Patients on immunosuppression\n* Uncontrolled diabetes\n* Known diagnosis of peripheral vascular disease or diagnosis at time of injury\n* Pregnant women\n* Patients with acquired defective color vision\n* Patients with subarachnoid hemorrhage\n* Patients with active intravascular clotting or known hypersensitivity reactions to tranexamic acid\n* Inability to give informed consent","ALL","18 Years",{"count":90,"type":91},62,"ESTIMATED","INTERVENTIONAL",[94],"PHASE4","Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base. The purpose of the study is to demonstrate that topical tranexamic acid will be a non-inferior alternative medication to the current standard of care,THROMBIN-JMI® , and at a lower cost to the health system.",[97,98],"Burns","Skin Graft Complications","2025-10-15",{"date":101,"type":102},"2025-10-20","ACTUAL",{"date":104,"type":102},"2024-07-11",{"date":106,"type":91},"2026-12",{"name":5,"class":6},1]