[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560717":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":58,"collaborators":26,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":26,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Weill Medical College of Cornell University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pitocin","ACTIVE_COMPARATOR","Control group will receive only the standard-dose synthetic oxytocin (Pitocin) alone for labor induction or augmentation.",[13],"Drug: Standard Dose Synthetic Pitocin",{"label":15,"type":16,"description":17,"interventionNames":18},"Calcium Carbonate with Pitocin","EXPERIMENTAL","Participants will start an oral calcium carbonate regimen at the same time as initiating synthetic oxytocin (Pitocin) infusion.",[19,13],"Drug: Calcium Carbonate 500 MG",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Calcium Carbonate 500 MG","Calcium Carbonate 500mg, orally, every 4 hours.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Standard Dose Synthetic Pitocin","The participant will receive thestandard-dose synthetic oxytocin for labor induction or augmentation.",[15,9],[32],{"name":33,"affiliation":5,"role":34},"Moeun Son, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Ester Sanchez, BSN","CONTACT","212-746-2106","ess4006@med.cornell.edu",[42],{"facility":43,"status":44,"city":45,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Weill Cornell Medicine","RECRUITING","New York","10065","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-74.00597,40.71427,{"lat":53,"lon":52},[56,57],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":59,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100560717","phase-4-calcium-carbonate-to-augment-labor-contractions-100560717",false,"NCT06580782","Calcium Carbonate to Augment Labor Contractions","CALC","Inclusion Criteria:\n\n* 18 years or older\n* Nulliparas (no prior pregnancy lasting 20 weeks or greater of gestation)\n* Gestational age above 36 weeks, at enrollment\n* Present for induction or augmentation of labor inclusive of medical indication, elective induction at greater than 39 weeks' gestation, trial of labor after cesarean\n* Singleton gestation (a multiple gestation reduced to a singleton, either spontaneously or therapeutically, before 14 0\u002F7 weeks of gestation is acceptable)\n* Ability to give informed consent\n* Planned to undergo initiation of oxytocin infusion by their maternity care provider\n\nExclusion Criteria:\n\n* Unable to understand or read English\n* Presence of tachysystole (defined as more than 5 contractions in 10 minutes averaged over 30 minutes), recurrent variable or late fetal decelerations, and bradycardia in the prior 30 minutes before enrollment\n* Non-vertex presenting fetus at enrollment\n* Planned for cesarean delivery or contraindication to labor by institutional policy (e.g., placenta previa, vasa previa, active genital herpes infection, previous transmural myomectomy)\n* Multi-fetal gestation (twins, triplets, and higher order multiples)\n* Known contraindication to taking calcium carbonate including renal calculus, high urine calcium levels, elevated serum calcium, low serum phosphate, achlorhydria, or suspected digoxin toxicity.\n* Deliveries with fetal chronic and\u002For pregnancy-related conditions, IUFD (Intra Uterine Fetal Death) or premature \\< 36 weeks of gestation.\n* Major fetal anomaly suspected prenatally (defined as a fetal anomaly with anticipated neonatal intensive care unit admission)\n* Suspected alloimmunization (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* Known severe fetal growth restriction (estimated fetal weight \\<3rd percentile) or abnormal umbilical artery Doppler studies (given the increased likelihood for anticipated neonatal intensive care unit admission)\n* Participation in another interventional study that influences management of labor and delivery or perinatal morbidity or mortality\n* Known allergic reactions to synthetic oxytocin intravenous solution or to Calcium Carbonate\n* Significantly impaired consciousness or executive function (e.g., intubated or sedated)\n* Patients treated with calcium channel blockers such as nifedipine or magnesium.\n* Chronic renal failure and hyperphosphatemia.\n* Inability to tolerate oral intake (i.e., nausea\u002Fvomiting)",true,"FEMALE","18 Years",{"count":71,"type":72},60,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","The investigators think that calcium carbonate can act as an assistive medication to improve contractions during labor.",[78,79,80],"Labor Dystocia","Labor Induction","Labor Augmentation",[82,83,80,84,85],"Labor","Pregnancy","Calcium Carbonate","labor induction","2025-10-21",{"date":88,"type":89},"2025-10-23","ACTUAL",{"date":91,"type":89},"2024-11-18",{"date":93,"type":72},"2025-12",{"name":5,"class":6},1]