[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623814":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":63,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":25,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Sheba Medical Center","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Carbetocin","EXPERIMENTAL","Participants in this arm will receive a single intravenous dose of carbetocin immediately after delivery of the second twin, as prophylaxis for postpartum hemorrhage, following either vaginal or cesarean delivery.",[13],"Drug: Carbetocin",{"label":15,"type":16,"description":17,"interventionNames":18},"Oxytocin (Standard Care)","ACTIVE_COMPARATOR","Participants in this arm will receive standard prophylactic oxytocin according to institutional protocol, following either vaginal or cesarean delivery.",[19],"Drug: Oxytocin",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Carbetocin will be administered as a single intravenous dose immediately following delivery of the second twin, according to institutional protocol, for the prevention of postpartum hemorrhage.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Oxytocin","Oxytocin will be administered intravenously according to standard institutional practice, for the prevention of postpartum hemorrhage.",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Avihu Krieger, MD","CONTACT","+972547421909","avihuey@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Tal Cahan, MD","+972528305662","Tal.Cahan@sheba.health.gov.il",[41],{"facility":5,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Ramat Gan","5262000","Israel","IL",{"type":48,"coordinates":49},"Point",[50,51],34.81065,32.08227,{"lat":51,"lon":50},[54,56,57,59,61],{"name":32,"role":33,"phone":55,"phoneExt":25,"email":35},"0547421909",{"name":25,"role":33,"phone":25,"phoneExt":25,"email":35},{"name":32,"role":58,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":37,"role":60,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":62,"role":60,"phone":25,"phoneExt":25,"email":25},"Michal Fishel-Bartal, MD",{"type":58,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Avihu Krieger","Principal Investigator and Physician, Department of Obstetrics and Gynecology","100623814","phase-4-carbetocin-uterotonic-treatment-in-twin-pregnancies-for-prevention-of-postpartum-hemorrhage-100623814",false,"NCT07401524","Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage","Carbetocin Administration for the Prevention of Postpartum Hemorrhage in Twin Deliveries: A Randomized Controlled Trial","CUTT-PPH","Inclusion Criteria:\n\n* Pregnant individuals aged ≥18 years\n* Twin pregnancies\n* Gestational age ≥23 weeks\n\nExclusion Criteria:\n\n* Known hypersensitivity or contraindication to carbetocin\n* Higher-order multiple gestation (triplets or more)\n* Maternal age \\\u003C18 years\n* Known placenta accreta spectrum\n* Known bleeding disorder\n* Intrauterine fetal death of one or more fetuses\n* Hyponatremia precluding oxytocin use\n* Planned delivery at a non-participating hospital","FEMALE","18 Years",{"count":77,"type":78},120,"ESTIMATED","INTERVENTIONAL",[81],"PHASE4","The goal of this clinical trial is to learn if the drug carbetocin works better than standard care to prevent heavy bleeding after childbirth in people carrying twin pregnancies. Heavy bleeding after delivery, also called postpartum hemorrhage, is more common after twin births and can lead to anemia, blood transfusions, and other serious health problems.\n\nIn this study, bleeding will be evaluated by measuring how much blood hemoglobin levels drop from before delivery to the day after delivery.\n\nThe main questions this study aims to answer are:\n\n* Does giving carbetocin after delivery lower blood loss compared with standard oxytocin treatment?\n* Is carbetocin safe and practical to use in twin deliveries?\n\nResearchers will compare carbetocin to standard oxytocin treatment to see which approach better prevents bleeding after twin vaginal or cesarean delivery.\n\nParticipants will:\n\n* Be randomly assigned to receive either carbetocin or standard oxytocin after the second twin is delivered\n* Have blood tests before delivery and on the day after delivery\n* Be followed during their hospital stay and for up to six weeks after delivery for safety outcomes",[84,85],"Postpartum Hemorrhage","Twin Pregnancy",[9,27,87,84],"Twin Delivery","2026-05-05",{"date":90,"type":91},"2026-05-08","ACTUAL",{"date":88,"type":91},{"date":94,"type":78},"2028-12-01",{"name":5,"class":6},1]