[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633919":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":61,"collaborators":63,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":93,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Murdoch Childrens Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention arm","EXPERIMENTAL","Oral antibiotics for the duration of the child's symptoms (minimum 3 days IV plus oral)",[13],"Drug: Antibiotics for duration of symptoms",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","ACTIVE_COMPARATOR","Oral antibiotics for the duration of the prescribed course (as per RCH Clinical Practice Guidelines for each infection)",[19],"Drug: Antibiotics for duration of prescribed course",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Antibiotics for duration of symptoms","Antibiotics for duration of child's symptoms",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Antibiotics for duration of prescribed course","Antibiotics for the duration of the prescribed course",[15],[32],{"name":33,"affiliation":5,"role":34},"A\u002FProf Penelope Bryant","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+61383416200","penelope.bryant@rch.org.au",{"name":41,"role":37,"phone":38,"phoneExt":26,"email":42},"Lucy Hill","lucy.hill@mcri.edu.au",[44],{"facility":45,"status":26,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Royal Children's Hospital","Melbourne","Victoria","3052","Australia","AU",{"type":52,"coordinates":53},"Point",[54,55],144.96332,-37.814,{"lat":55,"lon":54},[58,59,60],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[64],{"name":45,"class":6},"100633919","phase-4-clinical-efficacy-of-stopping-oral-antibiotics-when-symptoms-stop-compared-to-finishing-the-course-100633919",false,"NCT07532941","Clinical Efficacy of Stopping Oral Antibiotics When Symptoms Stop, Compared to 'Finishing the Course'","StopStop@HITH - Clinical Efficacy of Stopping Oral Antibiotics When Symptoms Stop, Compared to 'Finishing the Course', for Children With Bacterial Infections Through Hospital-in-the-Home (HITH): a Basket Randomised Controlled Trial (RCT)","StopStop@HITH","Inclusion Criteria:\n\n1. Between the ages of ≥ 1 years and ≤ 17 years at enrolment\n2. Diagnosis of cellulitis, urinary tract infection (UTI), lower respiratory tract infection (LRTI) or lymphadenitis\n3. Prescription of oral antibiotics as a switch from IV antibiotics\n\nExclusion Criteria:\n\n1. Clinician determined need for \\>10-day oral antibiotic course\n2. Child with immunosuppression (e.g. as a result of cancer treatment)\n3. Second episode of same bacterial infection within the last 28 days\n4. Child is unable to take oral antibiotics\n5. Previous enrolment in StopStop@HITH\n6. Parent\u002Fguardian does not speak English\n7. Clinician determined need for 10-day course of oral antibiotics for treatment\u002Fclearance of streptococcal infection\n8. UTI only: known impaired renal function (e.g. renal transplant patients or known chronic renal failure)\n9. LRTI only: known chronic respiratory condition (e.g. cystic fibrosis or bronchiectasis) or need for long term respiratory support (e.g. home oxygen, Continuous Positive Airway Pressure \\[CPAP\\] or tracheostomy); empyema or lung abscess","ALL","1 Year","17 Years",{"count":77,"type":78},200,"ESTIMATED","INTERVENTIONAL",[81],"PHASE4","The aim of the StopStop@HITH study is to see if stopping antibiotics when symptoms stop is as good as finishing the course of antibiotics. The study will enrol children at the Royal Children's Hospital who are prescribed oral antibiotics after completing a course of intravenous (IV) antibiotics for the treatment of cellulitis, urinary tract infection (UTI), lower respiratory tract infection (LRTI) and lymphadenitis.\n\nThe aims of the study are:\n\n* To determine if oral antibiotics can be safely stopped once symptoms stop in children with cellulitis (who have completed a course of IV antibiotics).\n* To assess feasibility of a larger study of other common infections across multiple hospitals.\n\nThe participants parent\u002Fguardian will complete a daily symptom tracker for the duration of the prescribed oral antibiotic course and attend a telehealth appointment with the study team once the participants symptoms have resolved. There are additional follow up surveys at day 14, day 28 and day 180.",[84,85,86,87],"Urinary Tract Infection","Cellulitis","Respiratory Tract Infections","Lymphadenitis",[89,90,91,92],"Infection","Antibiotics","Paediatrics","Symptom Guided","NOT_YET_RECRUITING","2026-04-08",{"date":96,"type":97},"2026-04-16","ACTUAL",{"date":99,"type":78},"2026-06",{"date":101,"type":78},"2028-06",{"name":5,"class":6},1]