[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559954":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":64,"collaborators":41,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":41,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":41,"enrollmentInfo":75,"targetDuration":41,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":50,"whyStopped":41,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Chiang Mai University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Colistin group","ACTIVE_COMPARATOR","Participants receive intravenous colistin (colistinmethate soidum) 5 mg\u002Fkg\u002Fday (dosage will be adjusted according to creatinine clearance) and colistin nebulization at 80 mg every 8 hours in case of pneumonia.",[13],"Drug: Colistin Sodium Methanesulfonate",{"label":15,"type":10,"description":16,"interventionNames":17},"Colistin plus fosfomycin group","Participants receive intravenous colistin (colistinmethate soidum) (dosage regimen same as colistin group plus intravenous fosfomycin (dosage will be adjusted according to creatinine clearance and MIC).",[18],"Drug: Colistin Sodium Methanesulfonate plus Fosfomycin",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Colistin Sodium Methanesulfonate","Intravenous colistin (colistinmethate soidum) 5 mg\u002Fkg\u002Fday intravenous (dosage will be adjusted according to creatinine clearance). The duration of treatment ranges from 10 to 14 days, depending on the site of infection and clinical responsiveness.",[9],[26],"Colistin",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Colistin Sodium Methanesulfonate plus Fosfomycin","Intravenous colistin(dosage is same as colistin group) plus intravenous fosfomycin(dosage will be adjusted according to MIC and creatinine clearance). The duration of treatment ranges from 10 to 14 days, depending on the site of infection and clinical responsiveness.",[15],[32],"Colistin plus fosfomycin",[34],{"name":35,"affiliation":5,"role":36},"Athitaya Luangnara","PRINCIPAL_INVESTIGATOR",[38,43],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","0954970567",null,"fenejung2@gmail.com",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Parichat Salee","0817830755","parichat.pimsarn@gmail.com",[48],{"facility":49,"status":50,"city":51,"state":41,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Faculty of medicine, Chiang Mai university","RECRUITING","Chiang Mai","50200","Thailand","TH",{"type":56,"coordinates":57},"Point",[58,59],98.98468,18.79038,{"lat":59,"lon":58},[62,63],{"name":35,"role":39,"phone":40,"phoneExt":41,"email":42},{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},{"type":36,"investigatorFullName":44,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":41,"oldOrganization":41},"Assistant professor Parichat sales","100559954","phase-4-colistin-monotherapy-vs-colsitin-fosfomycine-in-crab-infection-100559954",false,"NCT06570850","Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection","Efficacy of Colistin Monotherapy Versus Colistin Combined With Fosfomycin Against Carbapenem-Resistant Acinetobacter Baumannii Infections","Inclusion Criteria:\n\n* ≥ 20 years old patients who have CRAB infections (pneumonia, urinary tract infection, skin and soft tissue infection, bloodstream infection)\n* Able to provide informed consent or having a legal proxy who can provide informed consent in case the subject is unable to provide consent on his own\n\nExclusion Criteria:\n\n* Minimum inhibitory concentration (MIC) of colistin \\> 2 mg\u002FL\n* Complicated infection with inadequate source controlled\n* Intracranial infection\n* Infective endocarditis\n* Intraabdominal infection\n* Bone and joint infection\n* Allergic to or have contraindication(s) to any treatment regimen in the study\n* Polymicrobial infection with Carbapenem-resistant Psuedomonas aeruginosa, Carbapenem-resistant Enterobacterales (CRE), Vancomycin-resistant Enterococcus (VRE)\n* Pregnancy\n* Previous treatment with colistin or fosfomycin more than 96 hours\n* Life expectancy of 24 hour or less\n* Refusal to participate in the study\n* Hospice treatment","ALL","20 Years",{"count":76,"type":77},188,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","The goal of this clinical trial is to evaluate the efficacy of colistin compared with colistin plus fosfomycin against carbapenem-resistant Acinetobacter baumanii infection in Thailand. The main questions it aims to answer the following main questions:\n\n1. Which group has better clinical response at end of treatment\n2. Which group has better clinical response at 72 hours and micrological cure at 72 hours and at end of treatment",[83],"Infection Due to Carbapenem Resistant Acinetobacter",[85,86,26,87],"carbapenem resistant Acinetobacter baumanni","CRAB","Fosfomycin","2024-08-22",{"date":90,"type":91},"2024-08-26","ACTUAL",{"date":93,"type":91},"2023-04-01",{"date":95,"type":77},"2025-07",{"name":5,"class":6},1]