[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619871":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":52,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":18,"enrollmentInfo":68,"targetDuration":18,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Region Skane","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm-Nerve blocks in addition to Local Infiltration Analgesia","ACTIVE_COMPARATOR","Ultrasound guided nerve blocks are administered preoperatively in addition to the Local Infiltration Analgesia administered during surgery.\n\nNerve blocks used:\n\n1. Nerve to Vastus Medialis (NVM) block:\n\n   Injection: 5 ml ropivacaine 5% with clonidine 1.875 micrograms per ml\n2. Saphenous Nerve (SN) block:\n\n   Injection: 10 ml ropivacaine 0.5% with clonidine 1.875 micrograms per ml\n3. Anterior Femoral Cutaneous Nerve (AFCN) Block:\n\nAFCN divides into multiple branches at the level of the femoral triangle Injection: 1 ml ropivacaine 5% with clonidine 1.875 micrograms per ml per branch\n\nLocal Infiltration Analgesia (LIA):\n\n150 ml ropivacaine 2 mg\u002Fml with 0.5 mg adrenaline is infiltrated periarticular around the knee capsule, collateral ligaments, under the patella, and subcutaneously",[13],"Drug: Ropivacain 5 mg\u002Fml + Clonidine",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm - Local Infiltration Analgesia only","NO_INTERVENTION","No ultrasound guided nerve blocks are administered. Local Infiltration Analgesia (LIA) is the same as in the- intervention arm:\n\n150 ml ropivacaine 2 mg\u002Fml with 0.5 mg adrenaline is infiltrated periarticular around the knee capsule, collateral ligaments, under the patella, and subcutaneously",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Ropivacain 5 mg\u002Fml + Clonidine","Drug used in the block",[9],[26],{"name":27,"affiliation":28,"role":29},"Andreas Ekman, MD, PhD","VO Planned Operations, Trelleborg Hospital, and Lund University, Sweden","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":18,"email":35},"Fredrik Fellert, MD","CONTACT","+46736552249","fredrik.fellert@med.lu.se",{"name":27,"role":33,"phone":37,"phoneExt":18,"email":38},"+46702542552","andreas.ekman@med.lu.se",[40],{"facility":41,"status":42,"city":43,"state":18,"zip":18,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":18},"Department of Anaesthesiology, Trelleborg Hospital","RECRUITING","Trelleborg","Sweden","SE",{"type":47,"coordinates":48},"Point",[49,50],13.15691,55.37514,{"lat":50,"lon":49},{"type":53,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[55],{"name":56,"class":57},"Greta and Johan Kock Foundation","UNKNOWN","100619871","phase-4-combination-of-nerve-blocks-and-local-infiltration-analgesia-in-knee-arthroplasty-100619871",false,"NCT07350252","Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty","Postoperative Analgesia in Patients Undergoing Knee Replacement Surgery - a Study Comparing Intraoperative Local Infiltration Analgesia Only With Ultrasound-guided Nerve Blocks Added to Intraoperative Local Infiltration Analgesia, a Randomized Clinical Trial","BALIA","Inclusion Criteria:\n\n-Undergoing primary unilateral total knee arthroplasty\n\nExclusion Criteria:\n\n* Pregnancy\n* Coagulopathy or other bleeding disorder that precludes regional anesthesia\n* Allergy to local anesthetics\n* Inability to understand spoken and written Swedish\n* Unwillingness to participate in the study","ALL","18 Years",{"count":69,"type":70},200,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.",[76],"Osteo Arthritis of the Knee",[78],"Treatment","2026-05-04",{"date":81,"type":82},"2026-05-08","ACTUAL",{"date":84,"type":82},"2026-03-05",{"date":86,"type":70},"2027-09-01",{"name":5,"class":6},1]