[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639534":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":11,"centralContacts":50,"locations":56,"responsibleParty":70,"collaborators":11,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":11,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":11,"enrollmentInfo":82,"targetDuration":11,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":11,"overallStatus":91,"whyStopped":11,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Mons","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Alginate","ACTIVE_COMPARATOR",null,[13],"Drug: Alginate",{"label":15,"type":10,"description":11,"interventionNames":16},"Magaldrate",[17],"Drug: Magaldrate",{"label":19,"type":10,"description":11,"interventionNames":20},"Proton pump inhibitors",[21],"Drug: Proton Pump Inhibitor (PPI) Therapy",{"label":23,"type":10,"description":11,"interventionNames":24},"Sucralfate",[25],"Drug: Sucralfate",{"label":27,"type":10,"description":11,"interventionNames":28},"Anti-reflux diet",[29],"Behavioral: Diet",[31,35,38,41,45],{"type":32,"name":9,"description":33,"armGroupLabels":34,"otherNames":11},"DRUG","Use of Gaviscon anti-acid, anti-reflux",[9],{"type":32,"name":15,"description":36,"armGroupLabels":37,"otherNames":11},"use of Riopan drug",[15],{"type":32,"name":23,"description":39,"armGroupLabels":40,"otherNames":11},"use of Kéal sucralfate",[23],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":11},"Proton Pump Inhibitor (PPI) Therapy","Use of Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, Rabeprazole",[19],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":11},"BEHAVIORAL","Diet","Patients are recommended to adhere to a 3-month low-fat, low quick-release sugar, high-protein, alkaline, and plant-based diet. The consumption of fish and meat was authorized but reduced to low-fat fish and meat. The anti-reflux diet considered the exclusion\u002Freduction of additional triggers such as caffeine or theine, spices, tomatoes, fatty, cheese alcohol, and sparkling beverages.",[27],[51],{"name":52,"role":53,"phone":54,"phoneExt":11,"email":55},"Jérome R Lechien, MD, PhD, MS, FACS","CONTACT","+32 498 64 09 19","jerome.lechien@umons.ac.be",[57],{"facility":5,"status":11,"city":58,"state":11,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Mons","7000","Belgium","BE",{"type":63,"coordinates":64},"Point",[65,66],3.95229,50.45413,{"lat":66,"lon":65},[69],{"name":52,"role":53,"phone":54,"phoneExt":11,"email":55},{"type":71,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jerome lechien","Chairman & Professor of General Surgery","100639534","phase-4-comparative-effectiveness-of-alginate-magaldrate-sucralfate-proton-pump-inhibitors-and-diet-in-laryngopharyngeal-reflux-disease-100639534",false,"NCT07611162","Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux Disease","Inclusion Criteria:\n\n* Positive 24-h HEMII-pH \\> 1 event\n\nExclusion Criteria:\n\n* Smoker (\\>5 cigarettes\u002Fday) , alcohol dependence (\\>3 units\u002Fday),\n* upper respiratory tract infection within the last month,\n* pregnancy,\n* neurological or psychiatric illness,\n* previous history of neck surgery or trauma,\n* malignancy,\n* history of head and neck radiotherapy\n* active seasonal allergies or asthma.","ALL","18 Years",{"count":83,"type":84},800,"ESTIMATED","INTERVENTIONAL",[87],"PHASE4","The goal of this randomized controlled trial is to compare the effectiveness of different treatments for laryngopharyngeal reflux disease (LPRD) in adult patients with confirmed symptoms and signs of the condition. The main question it aims to answer is:\n\nWhich treatment (Proton Pump Inhibitors (PPIs), alginate, magaldrate, sucralfate, or diet) leads to the greatest improvement in LPRD symptoms and clinical signs over 3 months? Researchers will compare proton pump inhibitors to alternative medical treatments and dietary management to see which approach is most effective and better tolerated.\n\nParticipants will:\n\n* undergo a clinical ENT examination with scoring of reflux signs (RSA)\n* complete symptom questionnaires (RSS) assessing severity, frequency, and impact of symptoms\n* receive one of the study treatments (medication or dietary intervention)\n* be evaluated at baseline and again after 3 months of treatment",[90],"Laryngopharyngeal Reflux Disease","NOT_YET_RECRUITING","2026-05-20",{"date":94,"type":95},"2026-05-28","ACTUAL",{"date":97,"type":84},"2026-05-01",{"date":99,"type":84},"2030-05-01",{"name":5,"class":6},1]