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MD",{"facility":666,"status":62,"city":667,"state":668,"zip":669,"country":66,"countryCode":67,"cosmosGeoPoint":670,"geoPoint":674,"contacts":675},"Brown University Health","Providence","Rhode Island","02903",{"type":69,"coordinates":671},[672,673],-71.41283,41.82399,{"lat":673,"lon":672},[676,680,684],{"name":677,"role":51,"phone":678,"phoneExt":53,"email":679},"Deepica Chaudhary","401-606-4655","DChaudhary@brownhealth.org",{"name":681,"role":51,"phone":682,"phoneExt":53,"email":683},"Alexis DeMarco","401-606-4651","ADemarco@brownhealth.org",{"name":685,"role":47,"phone":53,"phoneExt":53,"email":53},"Roderick Spears, MD",{"facility":687,"status":62,"city":688,"state":689,"zip":690,"country":66,"countryCode":67,"cosmosGeoPoint":691,"geoPoint":695,"contacts":696},"Vanderbilt Medical Center","Nashville","Tennessee","37215",{"type":69,"coordinates":692},[693,694],-86.78444,36.16589,{"lat":694,"lon":693},[697,701,703],{"name":698,"role":51,"phone":699,"phoneExt":53,"email":700},"Jordon Winn","615-421-6094","Jordon.winn@vumc.org",{"name":702,"role":47,"phone":53,"phoneExt":53,"email":53},"Joy Derwenskus, MD",{"name":704,"role":100,"phone":53,"phoneExt":53,"email":53},"Francesca Bagnato, MS",{"facility":706,"status":62,"city":707,"state":708,"zip":709,"country":66,"countryCode":67,"cosmosGeoPoint":710,"geoPoint":714,"contacts":715},"DHR Health Headache Center","McAllen","Texas","78504",{"type":69,"coordinates":711},[712,713],-98.23001,26.20341,{"lat":713,"lon":712},[716,720,723],{"name":717,"role":51,"phone":718,"phoneExt":53,"email":719},"Leah Picazo","956-362-2234","Leah.Picazo@dhrhealth.com",{"name":721,"role":51,"phone":53,"phoneExt":53,"email":722},"Alexis Valencia","Alexis.Valencia@dhrhealth.com",{"name":724,"role":47,"phone":53,"phoneExt":53,"email":53},"Gloria Simms, MD",{"facility":726,"status":62,"city":727,"state":728,"zip":729,"country":66,"countryCode":67,"cosmosGeoPoint":730,"geoPoint":734,"contacts":735},"Advanced Research Institute Ogden","Ogden","Utah","84405",{"type":69,"coordinates":731},[732,733],-111.97383,41.223,{"lat":733,"lon":732},[736,740,743,745,747,749,751,753,755],{"name":737,"role":51,"phone":738,"phoneExt":53,"email":739},"Stephanie Church","801-409-2040","stephanie@advresearch.org",{"name":741,"role":51,"phone":738,"phoneExt":53,"email":742},"Noah Nielsen","noah@advresearch.org",{"name":744,"role":47,"phone":53,"phoneExt":53,"email":53},"Michael Woolman, MD",{"name":746,"role":100,"phone":53,"phoneExt":53,"email":53},"Jonathan N Winkfield, PA-C",{"name":748,"role":100,"phone":53,"phoneExt":53,"email":53},"Abbey Coburn, PA-C",{"name":750,"role":100,"phone":53,"phoneExt":53,"email":53},"Khaldoun M Al-Rayess, MD",{"name":752,"role":100,"phone":53,"phoneExt":53,"email":53},"Christopher L. Davis, DO",{"name":754,"role":100,"phone":53,"phoneExt":53,"email":53},"Lynae C Sorensen, MSN AP FNP-C",{"name":756,"role":100,"phone":53,"phoneExt":53,"email":53},"Michael D DeLange, MD",{"facility":758,"status":62,"city":759,"state":760,"zip":761,"country":66,"countryCode":67,"cosmosGeoPoint":762,"geoPoint":766,"contacts":767},"West Virginia University","Morgantown","West Virginia","26506",{"type":69,"coordinates":763},[764,765],-79.9559,39.62953,{"lat":765,"lon":764},[768,773,776,778,780,782,784,786],{"name":769,"role":51,"phone":770,"phoneExt":771,"email":772},"Lauren Chase RN, BSN","304-598-4000","79418","lauren.chase@wvumedicine.org",{"name":774,"role":51,"phone":53,"phoneExt":53,"email":775},"Bethany Moore, RPh","Bethany.moore2@wvumedicine.org",{"name":777,"role":47,"phone":53,"phoneExt":53,"email":53},"Umer Najib, MD",{"name":779,"role":100,"phone":53,"phoneExt":53,"email":53},"David Watson, MD",{"name":781,"role":100,"phone":53,"phoneExt":53,"email":53},"Kristina Lopez, MD",{"name":783,"role":100,"phone":53,"phoneExt":53,"email":53},"Tiffany Lannan, FNP-BC",{"name":785,"role":100,"phone":53,"phoneExt":53,"email":53},"Heather Hickman, FNP-BC",{"name":787,"role":100,"phone":53,"phoneExt":53,"email":53},"Lindsey S Keczan, FNP-BC",{"facility":789,"status":62,"city":790,"state":791,"zip":792,"country":66,"countryCode":67,"cosmosGeoPoint":793,"geoPoint":797,"contacts":798},"Marshfield Clinic Research Institute","Marshfield","Wisconsin","54449",{"type":69,"coordinates":794},[795,796],-90.1718,44.66885,{"lat":796,"lon":795},[799,803,807,809],{"name":800,"role":51,"phone":801,"phoneExt":53,"email":802},"Megan Johnson","715-389-5473","johnson.megan.a@marshfieldresearch.org",{"name":804,"role":51,"phone":805,"phoneExt":53,"email":806},"Stacy Welter","715-221-6492","welter.stacy@marshfieldresearch.org",{"name":808,"role":47,"phone":53,"phoneExt":53,"email":53},"Jeff VanWormer, PhD",{"name":810,"role":100,"phone":53,"phoneExt":53,"email":53},"Lee Cody, MD",{"facility":812,"status":62,"city":813,"state":791,"zip":814,"country":66,"countryCode":67,"cosmosGeoPoint":815,"geoPoint":819,"contacts":820},"The Medical College of Wisconsin","Milwaukee","53226",{"type":69,"coordinates":816},[817,818],-87.90647,43.0389,{"lat":818,"lon":817},[821,825,829,831],{"name":822,"role":51,"phone":823,"phoneExt":53,"email":824},"Karen Schmidt, RN","(414) 955-0674","kaschmidt@mcw.edu",{"name":826,"role":51,"phone":827,"phoneExt":53,"email":828},"Victoria Ochotnicky","(414) 955-0659","vochotnicky@mcw.edu",{"name":830,"role":47,"phone":53,"phoneExt":53,"email":53},"Glen Soloman, MD",{"name":832,"role":100,"phone":53,"phoneExt":53,"email":53},"James Murtha, MD",{"type":47,"investigatorFullName":834,"investigatorTitle":835,"investigatorAffiliation":5,"oldNameTitle":53,"oldOrganization":53},"Todd J. Schwedt","Principal Investigator",[837,839,841],{"name":838,"class":6},"University of Iowa",{"name":840,"class":6},"Patient-Centered Outcomes Research Institute",{"name":842,"class":843},"AbbVie","INDUSTRY","100590794","phase-4-comparative-effectiveness-of-migraine-preventive-medications-the-apt-comparison-study-100590794",false,"NCT06972056","Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study","A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study","Inclusion Criteria:\n\n* Adults, 18-70 years of age at the time of enrollment\n* Migraine with aura, migraine without aura, and\u002For chronic migraine; according to ICHD-3 diagnostic criteria. (Those with daily or continuous headaches are not excluded.)\n* Migraine onset prior to 50 years of age\n* Migraine present for at least 12 months at the time of enrollment\n* At least four \"moderate to severe headache days\" per month (by patient self-report and then confirmed during four-week pre-randomization headache diary phase) A \"moderate to severe headache day\" is defined as a day during which there is a headache of moderate to severe intensity that lasts for at least four hours, or a day on which a migraine-specific acute medication is taken to treat headache.\n* If already taking a migraine preventive treatment, willing to continue with that treatment without dose change during the first 16 weeks of the study, including the 4-week run-in phase and 12-week randomized phase.\n* Not pregnant or breastfeeding\n* Women of childbearing potential must agree to use effective methods of contraception to reduce the risk of pregnancy.\n* Willingness and ability to provide informed consent.\n* Willingness and ability to complete all research visits.\n\nExclusion Criteria:\n\n* Contraindications to taking atogepant, propranolol, or topiramate.\n* Currently taking atogepant, propranolol, or topiramate\\*\n* Previously took atogepant, propranolol, or topiramate\\*\n* Unwillingness to take atogepant, topiramate, or propranolol.\n* Current use of a CGRP-targeting preventive medication or beta-blocker\n* Migraine with brainstem aura\n* Hemiplegic migraine\n* Retinal migraine\n* Migraine aura without headache (exclusively)\n* Pure menstrual migraine\n* Trigeminal autonomic cephalalgias\n* Facial neuralgias\n* Secondary headache disorders (medication overuse headache is not an exclusion)\n* Migraine preventive treatment has been started or dose has been changed within 12 weeks prior to potential enrollment.\n* Used opioids or butalbital on five or more days per month on average for at least 3 months prior to enrollment.\n* Current or past epilepsy\n* Severe hepatic impairment\n* Moderate or more severe renal impairment \\* Occasional as needed use of propranolol, currently or in the past, is not an exclusion, such as taking as needed propranolol for treatment of anxiety.","ALL","18 Years","70 Years",{"count":855,"type":856},1335,"ESTIMATED","INTERVENTIONAL",[859],"PHASE4","This goal of this study is to compare three medications used for migraine preventive treatment.\n\nThis study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others.\n\nResearch participants will:\n\n* Be randomly assigned to one of the three medications.\n* Provide information about their migraine pattern using a daily headache diary and during research visits.",[862],"Migraine",[862,864,865],"Migraine with aura","Migraine prevention","2026-06-25",{"date":868,"type":869},"2026-06-29","ACTUAL",{"date":871,"type":869},"2025-07-09",{"date":873,"type":856},"2029-12-01",{"name":5,"class":6},35]