[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644517":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":31,"locations":31,"responsibleParty":40,"collaborators":31,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":31,"eligibilityCriteria":49,"healthyVolunteers":46,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":31,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":72,"whyStopped":31,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":31},{"fullName":5,"class":6},"Menoufia University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Interscalene Block (ISB)","ACTIVE_COMPARATOR","Ultrasound-guided interscalene brachial plexus block targeting the C5-C6 roots, performed approximately 1 hour before surgery. Injectate: 10 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg.",[13],"Procedure: Ultrasound-guided interscalene brachial plexus block",{"label":15,"type":16,"description":17,"interventionNames":18},"Suprascapular Nerve Block (SSNB)","EXPERIMENTAL","Ultrasound-guided suprascapular nerve block was performed proximal to the transverse scapular ligament, approximately 1 hour before surgery. Injectate: 10 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg.",[19],"Procedure: Ultrasound-guided suprascapular nerve block",{"label":21,"type":16,"description":22,"interventionNames":23},"Costoclavicular Block (CCB)","Ultrasound-guided costoclavicular brachial plexus block targeting the brachial plexus cords in the costoclavicular space, approximately 1 hour before surgery. Injectate: 20 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg.",[24],"Procedure: Ultrasound-guided costoclavicular brachial plexus block",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Ultrasound-guided interscalene brachial plexus block","Ultrasound-guided interscalene brachial plexus block performed \\~1 hour before surgery. With the patient supine and head rotated contralaterally, a high-frequency linear transducer identifies the C5-C6 roots between the anterior and middle scalene muscles. Using an in-plane technique, 10 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg is injected with frequent aspiration.",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Ultrasound-guided suprascapular nerve block","Ultrasound-guided suprascapular nerve block performed \\~1 hour before surgery. A linear high-frequency probe in the supraclavicular region identifies the suprascapular nerve. A 22-gauge echogenic needle is advanced in-plane to the nerve proximal to the transverse scapular ligament, and 10 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg is injected under real-time ultrasound, confirming circumferential spread.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Ultrasound-guided costoclavicular brachial plexus block","Ultrasound-guided costoclavicular brachial plexus block performed \\~1 hour before surgery. With the operative arm abducted \\~60°, a linear probe inferior to the mid-clavicle visualizes the three brachial plexus cords lateral to the axillary artery. An echogenic needle is advanced in-plane into the interfascial plane, and 20 mL of 0.25% bupivacaine combined with dexmedetomidine 0.5 µg\u002Fkg is injected with aspiration and ultrasound confirmation of homogeneous spread.",[21],{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Mahdy Mohamed Elghanam","Assisstant Lecture Menoufia University","100644517","phase-4-comparative-evaluation-of-diaphragmatic-function-following-interscalene-anterior-suprascapular-and-costoclavicular-nerve-blocks-in-shoulder-surgery-100644517",false,"NCT07671352","Comparative Evaluation of Diaphragmatic Function Following Interscalene, Anterior Suprascapular, and Costoclavicular Nerve Blocks in Shoulder Surgery","Inclusion Criteria:\n\nAdults of both sexes, aged 18 to 70 years American Society of Anesthesiologists (ASA) physical status I-II Scheduled for elective shoulder surgery\n\nExclusion Criteria:\n\nPulmonary disease or baseline diaphragmatic dysfunction Refusal to provide informed consent Pre-existing neuropathy in the operated limb Allergy to local anesthetics Infection at the injection site Coagulopathy Pregnancy","ALL","18 Years","80 Years",{"count":54,"type":55},75,"ESTIMATED","INTERVENTIONAL",[58],"PHASE4","Shoulder surgery causes significant postoperative pain, and ultrasound-guided regional anesthesia is central to its management. The interscalene block (ISB) is the gold standard but frequently causes phrenic nerve paralysis and hemi-diaphragmatic paresis, limiting its use in patients with reduced pulmonary reserve. The suprascapular (SSNB) and costoclavicular (CCB) blocks are proposed diaphragm-sparing alternatives, but data directly comparing all three are limited.\n\nThis randomised, double-blinded trial will compare the incidence of hemi-diaphragmatic paresis among ultrasound-guided ISB, SSNB, and CCB in elective shoulder surgery. Seventy-five ASA I-II patients aged 18-70 will be allocated 1:1:1 to one block. The primary outcome is the incidence of hemi-diaphragmatic paresis, measured by ultrasound diaphragmatic excursion before induction and after recovery in the PACU. Secondary outcomes include postoperative pain, analgesic consumption, and patient satisfaction. The investigators hypothesise that SSNB and CCB will cause less hemidiaphragmatic paresis than ISB while providing comparable analgesia.",[61,62,63,64],"Hemidiaphragmatic Paralysis","Postoperative Pain","Shoulder Surgery","Brachial Plexus Block",[66,67,68,69,70,71],"Interscalene block","Suprascapular nerve block","Costoclavicular block","Diaphragmatic excursion","Ultrasound-guided regional anesthesia","Phrenic nerve palsy","NOT_YET_RECRUITING","2026-06-22",{"date":75,"type":76},"2026-06-26","ACTUAL",{"date":78,"type":55},"2026-06-25",{"date":80,"type":55},"2027-01-01",{"name":5,"class":6}]