[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550069":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":52,"responsibleParty":69,"collaborators":31,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":31,"enrollmentInfo":82,"targetDuration":31,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":54,"whyStopped":31,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Medical University of Vienna","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Enoxaparin group","EXPERIMENTAL","Anticoagulation for the duration of the study will be conducted using subcutaneous Enoxaparin",[13],"Drug: Enoxaparin Injectable Solution",{"label":15,"type":10,"description":16,"interventionNames":17},"Argatroban group","Anticoagulation for the duration of the study will be conducted using intravenous Argatroban.",[18],"Drug: Argatroban, 1 Mg\u002FmL Intravenous Solution",{"label":20,"type":21,"description":22,"interventionNames":23},"Unfractionated heparin group","ACTIVE_COMPARATOR","Anticoagulation for the duration of the study will be conducted using intravenous unfractionated heparin",[24],"Drug: Unfractionated heparin",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Enoxaparin Injectable Solution","Subcutaneous Enoxaparin will be dosed at 0.5 mg\u002Fkg twice daily",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Argatroban, 1 Mg\u002FmL Intravenous Solution","Intravenous Argatroban will be administered as a continuous infusion of 0.1-1 µg\u002Fkg\u002Fmin with a target modified thrombin time measured using Hemoclot of 0,40 - 0,60 µg\u002FmL.",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Unfractionated heparin","Unfractionated heparin will be administered as a continuous infusion of 7.5-20 units\u002Fkg\u002Fh with a target Anti FXa calibrated for UFH of 0.3-0.5 u\u002FmL.",[20],[41],{"name":42,"affiliation":43,"role":44},"Johannes Gratz, PD, MD, PhD","Medical Univeristy of Vienna","PRINCIPAL_INVESTIGATOR",[46],{"name":47,"role":48,"phone":49,"phoneExt":50,"email":51},"Vincenz Scharner, MD","CONTACT","+43 1 40400","4100","vincenz.scharner@meduniwien.ac.at",[53],{"facility":5,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Vienna","State of Vienna","1090","Austria","AT",{"type":61,"coordinates":62},"Point",[63,64],16.37208,48.20849,{"lat":64,"lon":63},[67],{"name":68,"role":48,"phone":31,"phoneExt":31,"email":51},"Vincenz Scharner, Dr. med.",{"type":44,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Johannes Gratz","Principal Investigator","100550069","phase-4-comparing-anticoagulation-strategies-using-ufh-argatroban-and-lmwh-for-ecmo-support-100550069",false,"NCT06442267","Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support","A Three-arm Randomized Controlled Non-inferiority Pilot Study Comparing Anticoagulation Strategies Using Unfractionated Heparin, Argatroban and Low-molecular-weight Heparin for Extracorporeal Membrane Oxygenation Support","CASUAL-ECMO","Inclusion Criteria:\n\n* either\n\n  * require ECMO support or\n  * have been started on ECMO therapy within the last 12 hours\n\nExclusion Criteria:\n\n* Patients exhibiting contraindications to anticoagulation in general or any of the three investigated substances\n* Patients who are pregnant\n* Patients suffering from a clinically relevant pre-existing coagulopathy\n* Patients, for whom screening, randomization and implementation of study protocol cannot be initiated within 12 hours after cannulation\n* Patients receiving ongoing therapeutic systemic anticoagulation prior to ECMO implantation, or exhibiting an indication for therapeutic anticoagulation (e.g., pulmonary embolism)\n* Patients whose total duration of ECMO support lasts less than 24 hours\n* Patients with start of ECMO support during CPR (eCPR)\n* Patients with passive decarboxylation, without an active pumping system\n* Patients, who have been weaned off ECMO support within the last 30 days\n* Patients with central ECMO cannulation and\u002For after cardiopulmonary bypass","ALL","18 Years",{"count":83,"type":84},90,"ESTIMATED","INTERVENTIONAL",[87],"PHASE4","A three-arm randomized controlled non-inferiority pilot study comparing anticoagulation strategies using unfractionated heparin, argatroban and enoxaparin for extracorporeal membrane oxygenation support conducted as an investigator-initiated, prospective, parallel group, open-label, active comparator controlled, single center, phase IV study to evaluate the non-inferiority of enoxaparin or argatroban for anticoagulation during ECMO therapy in comparison to the current standard, unfractionated heparin, as measured by the incidence of thromboembolic events during the duration of ECMO therapy",[90,91,92,93],"Respiratory Insufficiency","Circulatory Failure","Thromboembolism","Bleeding",[95,96,97,93,98,99,100],"ECMO","Anticoagulation","Thromboembolic Event","extracorporeal life support","anticoagulant","heparin","2024-10-26",{"date":103,"type":104},"2024-10-29","ACTUAL",{"date":106,"type":104},"2024-07-30",{"date":108,"type":84},"2027-07-30",{"name":5,"class":6},1]