[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644503":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":54,"collaborators":26,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":26,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":73,"overallStatus":75,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"General Hospital of Ningxia Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ciprofol treatment group","EXPERIMENTAL","This group plans to enroll a total of 54 elderly patients aged 65-80 who will undergo brief procedures without intubation, using spontaneous respiration under general anesthesia. The intravenous infusion of cyclopropane hydrochloride injection will be administered at a constant rate of 10 ml\u002Fmin. The administration will cease when the MOAA\u002FS score is ≤1. Throughout the procedure, hemodynamic parameters (HR, SBP, DBP, MAP, CO, SV,SVR), and respiratory parameters (SpO₂, respiratory rate (RR), PETCO₂), and various anesthetic adverse reactions will be monitored within the first 5 minutes after induction. The safety of the medication will be evaluated in comparison with the control group",[13],"Drug: Ciprofol Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Propofol Control group","ACTIVE_COMPARATOR","This study aims to enroll 54 elderly patients aged 65-80 with short procedures and no need for intubation, who will receive propofol intravenously at a constant rate of 10 ml\u002Fmin until their MOAA\u002FS score drops to ≤1 point. Circulatory and respiratory parameters, as well as adverse events, will be recorded simultaneously 5 minutes after induction. This will allow for a parallel comparison of the two medications' effects on the circulatory and respiratory systems of elderly patients with the propofol control group.",[19],"Drug: Propofol Injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Propofol Injection","Intravenous administration, injection rate of 10 ml\u002Fmin, continuous and uniform infusion until the patient's MOAA\u002FS sedation score is ≤1 point. This is used for the induction of general anesthesia in short-duration medical procedures for elderly individuals aged 65-80 without intubation and with spontaneous respiration",[15],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Ciprofol Injection",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Hanxiang Ma Ma, master","CONTACT","13519591508","mahanxiang@hotmail.com",{"name":37,"role":33,"phone":38,"phoneExt":26,"email":39},"LI Mo Mo, Bachelor","17752025907","ml185030153@163.com",[41],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":26},"Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University","Yinchuan","Ningxia","750000","China","CN",{"type":49,"coordinates":50},"Point",[51,52],106.27306,38.46806,{"lat":52,"lon":51},{"type":55,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100644503","phase-4-comparison-of-hemodynamics-and-respiratory-function-between-ciprofol-and-propofol-in-elderly-patients-undergoing-non-intubated-general-anesthesia-100644503",false,"NCT07670923","Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia","Inclusion Criteria:\n\n1. Patients scheduled for elective non-intubated general anesthesia\n2. Age ranging from 65 to 80 years old\n3. American Society of Anesthesiologists (ASA) physical status class I-III\n4. Written informed consent signed by the patient or legal guardian\n\nExclusion Criteria:\n\n1. Confirmed allergy to propofol, ciprofol or their excipients\n2. Severe cardiovascular diseases (uncontrolled hypertension, heart failure, severe arrhythmia, etc.)\n3. Severe respiratory diseases (chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, etc.)\n4. Severe hepatic or renal insufficiency\n5. Long-term regular use of sedatives or opioids\n6. Baseline bradycardia (HR \\\u003C 50 beats\u002Fmin) or hypoxemia (SpO₂ \\\u003C 90%)","ALL","65 Years","80 Years",{"count":66,"type":67},108,"ESTIMATED","INTERVENTIONAL",[70],"PHASE4","At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL\u002Fmin. The Modified Observer's Assessment of Alertness\u002FSedation (MOAA\u002FS) scale will be used to evaluate sedation depth. This study aims to assess the effects of ciprofol and propofol on hemodynamics and respiratory function in elderly patients undergoing non-intubated general anesthesia.",[60],[74],"Ciprofol; Propofol; Elderly patients; Intubation-free general anesthesia; Hemodynamics; Respiratory function","NOT_YET_RECRUITING","2026-06-22",{"date":78,"type":79},"2026-06-26","ACTUAL",{"date":81,"type":67},"2026-07-01",{"date":83,"type":67},"2027-04-01",{"name":5,"class":6},1]