[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526818":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":44,"responsibleParty":75,"collaborators":26,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":79,"sex":85,"minAge":86,"maxAge":26,"enrollmentInfo":87,"targetDuration":26,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":26,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Jinling Hospital, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"the dexmedetomidine group","EXPERIMENTAL","In the experimental group, dexmedetomidine is used for intraoperative sedation. Dexmedetomidine is prepared as an 8μg\u002Fml intravenous infusion. It begins with an initial loading dose of 1μg\u002Fkg, administered over a period exceeding 10 minutes.If dexmedetomidine fails to achieve a satisfactory level of sedation during surgery, physicians may opt for rescue sedation with propofol or consider transferring the patient to general anesthesia. Propofol (20ml 0.2g) starts with a loading dose of 0.3mg\u002F(kg\\*h) and a maintenance dose of 0.3-4mg\u002F(kg\\*h). The infusion rate can be adjusted based on the sedation effect to achieve the appropriate level of sedation during EVT.",[13],"Drug: Dexmedetomidine",{"label":15,"type":16,"description":17,"interventionNames":18},"the midazolam group","ACTIVE_COMPARATOR","In the control group, midazolam is used for intraoperative sedation. Midazolam is prepared as a 1mg\u002Fml intravenous infusion. It starts with an initial intravenous push of 0.05mg\u002Fkg, followed by a maintenance dose of 0.04-0.2mg\u002Fkg administered intravenously via an infusion pump. If midazolam fails to achieve a satisfactory level of sedation during surgery, physicians may opt for rescue sedation with propofol or consider transferring the patient to general anesthesia. Propofol (20ml 0.2g) starts with a loading dose of 0.3mg\u002F(kg\\*h) and a maintenance dose of 0.3-4mg\u002F(kg\\*h). The infusion rate can be adjusted based on the sedation effect to achieve the appropriate level of sedation during EVT.",[19],"Drug: Midazolam",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexmedetomidine","Patients receive perioperative sedation with dexmedetomidine",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Midazolam","Patients receive perioperative sedation with midazolam",[15],[32],{"name":33,"affiliation":34,"role":35},"Xinfeng Liu","Department of Neurology, Jinling Hospital, China","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Rui Liu","CONTACT","+86 2584801861","liurui8616@163.com",{"name":33,"role":39,"phone":40,"phoneExt":26,"email":43},"xfliu2@vip.163.com",[45,62],{"facility":46,"status":47,"city":48,"state":49,"zip":26,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Jinling Hospital, Medical School of Nanjing University","RECRUITING","Nanjing","None Selected","China","CN",{"type":53,"coordinates":54},"Point",[55,56],118.77778,32.06167,{"lat":56,"lon":55},[59,61],{"name":38,"role":39,"phone":60,"phoneExt":26,"email":41},"+862584801861",{"name":33,"role":39,"phone":60,"phoneExt":26,"email":43},{"facility":63,"status":47,"city":64,"state":26,"zip":26,"country":50,"countryCode":51,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"The General Hospital of Western Theater Command PLA","Chengdu",{"type":53,"coordinates":66},[67,68],104.06667,30.66667,{"lat":68,"lon":67},[71],{"name":72,"role":39,"phone":73,"phoneExt":26,"email":74},"Yao Huang","+86-18608398843","m15928868662@163.com",{"type":35,"investigatorFullName":33,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Professor","100526818","phase-4-comparison-of-perioperative-conscious-sedation-during-endovascular-thrombectomy-in-acute-ischemic-stroke-100526818",false,"NCT06139692","Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke","Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke (PEACE) A Randomised Multicentre Trial","PEACE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Presenting with symptoms of acute ischemic stroke\n3. CTA or MRA confirmed occlusion of the anterior circulation (intracranial carotid artery or M1, M2 segment of the middle cerebral artery)\n4. Randomization finished within 24 hours of symptom onset or time last know well\n5. Pre-stroke mRS score ≤2\n6. NIHSS score ≥6 at the time of randomization\n7. ASPECTS value ≥3\n8. Informed consent signed\n\nExclusion Criteria:\n\nGeneral exclusion criteria\n\n1. Pregnant or lactating women\n2. Known allergy to contrast agents or nitinol devices\n3. Known allergy to midazolam or other benzodiazepines\n4. Known allergy to dexmedetomidine or its components\n5. Planned to receive general anesthesia for EVT\n6. Uncontrolled hypertension or hypotension (defined as systolic blood pressure \\>185 mmHg or \\\u003C 90 mmHg, diastolic blood pressure \\>110 mmHg or \\\u003C 60 mmHg)\n7. Second-degree or third-degree heart blockage or bradyarrhythmia with a baseline heart rate lower than 50 beats\u002Fmin\n8. Any major surgery or serious trauma within 14 days\n9. Known genetic or acquired bleeding diathesis (platelet count \\\u003C 100\\\\\\*109 \u002FL, activated partial thromboplastin time \\> 50 s or international normalized ratio \\> 1.7)\n10. Blood glucose \\\u003C2.8 or \\> 22.2 mmol\u002FL\n11. Severe renal insufficiency (defined as glomerular filtration rate \\\u003C30 ml\u002Fmin or serum creatinine \\>220 mmol\u002FL (2.5mg\u002Fdl))\n12. Receiving hemodialysis or peritoneal dialysis\n13. Life expectancy less than 1 year\n14. Severe agitation or seizures\n15. Clinical manifestations of central nervous system vasculitis\n16. Premorbid neurological disease or mental disorders confounding evaluation\n17. Unwilling to be followed up within 90 days\n18. Participation in other interventional randomized clinical trials Imaging exclusion criteria\n\n1\\. Evidence of intracranial hemorrhage on CT or MRI 2. Cerebellar infarction with obvious space-occupying effects and fourth ventricle compression on CT or MRI 3. Any untreated or incompletely treated intracranial aneurysm or any intracranial vascular malformation 4. Bilateral occlusion or multiple intracranial vessels occlusions 5. Intracranial tumors (with mass effect)","ALL","18 Years",{"count":88,"type":89},810,"ESTIMATED","INTERVENTIONAL",[92],"PHASE4","This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic stroke patients with large vessel occlusion in the anterior circulation.",[95],"Acute Ischemic Stroke","2025-11-16",{"date":98,"type":99},"2025-11-18","ACTUAL",{"date":101,"type":99},"2023-11-21",{"date":103,"type":89},"2026-06-13",{"name":5,"class":6},2]