[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636108":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":59,"collaborators":11,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":11,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":11,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":43,"whyStopped":11,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Al-Shifa Trust Eye Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group Topical Insulin","ACTIVE_COMPARATOR",null,[13],"Drug: Topical insulin eye drops",{"label":15,"type":10,"description":11,"interventionNames":16},"Group Amniotic Membrane graft",[17],"Procedure: Amniotic Membrane Graft",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Topical insulin eye drops","Topical Insulin eye drops will be administered every 6 hours till healing of corneal epithelial defects",[9],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"PROCEDURE","Amniotic Membrane Graft","Surgically amniotic membrane grafts will be applied to bridge and heal the corneal defects",[15],[30],{"name":31,"affiliation":32,"role":33},"Shama Khan, MBBS,FCPS","Senior Consultant Cornea Department","STUDY_CHAIR",[35],{"name":36,"role":37,"phone":38,"phoneExt":11,"email":39},"Subha Mashaam Principal Investigator, MBBS","CONTACT","+92-340-6805428","creativedoctor@gmail.com",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Al Shifa Eye Trust Hospital","RECRUITING","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":50,"coordinates":51},"Point",[52,53],73.0479,33.59733,{"lat":53,"lon":52},[56],{"name":31,"role":37,"phone":57,"phoneExt":11,"email":58},"+92-3350928355","dr.shamakhan@hotmail.com",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Subha Masham","Principal Investigator","100636108","phase-4-comparison-of-topical-insulin-and-amniotic-membrane-transplant-for-persistent-corneal-epithelial-defects-100636108",false,"NCT07561398","Comparison of Topical Insulin and Amniotic Membrane Transplant for Persistent Corneal Epithelial Defects","Comparison of Efficacy of Topical Insulin With Amniotic Membrane Transplant in Persistent Epithelial Defects of Cornea","Inclusion Criteria:\n\n* Corneal epithelial defects for more than 2 weeks no improvement using standard treatment\n\nExclusion Criteria:\n\n* • Systemic conditions e.g. uncontrolled Diabetes, autoimmune disorders\n\n  * Recent eye surgery within last 3 months\n  * Hereditary corneal dystrophies\n  * Active eye infections",true,"ALL","16 Years","70 Years",{"count":75,"type":76},214,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","After an initial period of standard treatment, they received further care aimed at helping the surface of the eye heal. Clear instructions were given on how to use and store the treatment properly. Patients were then monitored regularly over several months, with doctors checking their healing progress during follow-up visits. The study continued for a total of 24 weeks to observe how well and how quickly the eye surface recovered.",[82],"Persistent Corneal Epithelial Defect",[84,85],"Topical Insulin","Amniotic Membrane graft","2026-04-28",{"date":88,"type":89},"2026-05-01","ACTUAL",{"date":91,"type":89},"2026-03-27",{"date":93,"type":76},"2026-09-27",{"name":5,"class":6},1]