[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535189":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":59,"whyStopped":26,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Hassan II University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Phenylephrine","ACTIVE_COMPARATOR","The infusion will have a concentration of Phenylephrine of 25 μg\u002FmL and will be initiated at a rate of 96 mL\u002Fhour (1.6 mL\u002Fminute), that correspond to a phenylephrine rate infusion of 40 μg\u002Fmin, then the infusion rate will be manually adjusted within the range 0-144 mL\u002Fh : PHE (0-60 μg\u002Fmin).",[13],"Drug: Continuous infusion of Phenylephrine",{"label":15,"type":16,"description":17,"interventionNames":18},"Norepinephrine","EXPERIMENTAL","The infusion will have a concentration of Norepinephrine of 4 μg\u002FmL and will be initiated at a rate of 96 mL\u002Fhour (1.6 mL\u002Fminute), that correspond to norepinephrine rate infusion of 6.4 μg\u002Fmin, then the infusion rate will be manually adjusted within the range 0-144 mL\u002Fh : Norepinephrine (0-9.6 µg\u002Fmin).",[19],"Drug: Continuous infusion of Norepinephrine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Continuous infusion of Norepinephrine","The rate of norepinephrine infusion will be adjusted according to values of systolic blood pressure measured noninvasively and recorded at 1-minute intervals along the intraoperative period, with the objective of maintaining values near baseline.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Continuous infusion of Phenylephrine","The rate of phenylephrine infusion will be adjusted according to values of systolic blood pressure measured noninvasively and recorded at 1-minute intervals along the intraoperative period, with the objective of maintaining values near baseline.",[9],[32],{"name":33,"affiliation":34,"role":35},"Mohamed Adnane Berdai, MD-PhD","University hospital Hassan II, Fes, Morocco","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+212655260752","adnane.berdai@yahoo.fr",[42,58],{"facility":43,"status":44,"city":45,"state":26,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"University hospital Hassan II","NOT_YET_RECRUITING","Fes","30060","Morocco","MA",{"type":50,"coordinates":51},"Point",[52,53],-5.00028,34.03313,{"lat":53,"lon":52},[56,57],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":43,"status":59,"city":45,"state":26,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"RECRUITING",{"type":50,"coordinates":61},[52,53],{"lat":53,"lon":52},[64],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},{"type":35,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Mohamed Adnane Berdai","Clinical professor","100535189","phase-4-continuous-infusion-of-norepinephrine-vs-phenylephrine-during-spinal-anesthesia-for-cesarean-section-inpeace-100535189",false,"NCT06248593","Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)","Manually Controlled Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section: A Double-blinded Randomized Controlled Study","INPEACE","Inclusion Criteria:\n\n* Full-term, singleton, pregnant women, nonlaboring.\n* Scheduled for elective cesarean delivery under spinal anesthesia,\n* American Society of Anesthesiologists physical status : 1 or 2\n* Baseline systolic BP between 90 and 140 mm Hg.\n\nExclusion Criteria:\n\n* Known fetal abnormality.\n* Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease.\n* Contraindication to spinal anesthesia.\n* Peripartum hemorrhage.\n* Body mass index above 40 kg\u002Fm2.","FEMALE","18 Years","45 Years",{"count":80,"type":81},140,"ESTIMATED","INTERVENTIONAL",[84],"PHASE4","The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are:\n\n* Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ?\n* Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.",[87,88],"Cesarean Section Complications","Hypotension",[90,91,92,93,94,9],"hypotension","norepinephrine","cesarean delivery","Obstetric anesthesia","Spinal anesthesia","2025-09-08",{"date":97,"type":98},"2025-09-09","ACTUAL",{"date":100,"type":98},"2025-01-29",{"date":102,"type":81},"2026-03-15",{"name":5,"class":6},2]