[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576406":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":38,"responsibleParty":56,"collaborators":26,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":26,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":26,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of California, San Diego","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous adductor canal block","EXPERIMENTAL","single injection with ropivacaine (0.5%) of the adductor canal block and a 5-day continuous perineural infusion of ropivacaine (0.2%) (experimental group)",[13],"Device: continuous peripheral nerve block with OnQ pump",{"label":15,"type":16,"description":17,"interventionNames":18},"single injection adductor canal block","ACTIVE_COMPARATOR","single injection with ropivacaine (0.5%) of the adductor canal block and no continuous nerve block added",[19],"Drug: single injection nerve block",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","continuous peripheral nerve block with OnQ pump","For continuous nerve blocks, the infusion pump that will be used are OnQ pumps (Avanos, Alpharetta, GA) and pre-filled with ropivacaine 0.2% and provided by UCSD's Investigational Drug Services.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","single injection nerve block","An adductor canal single injection nerve block will be performed per standard of care. The adductor canal will be identified by ultrasound in the short-axis view. The distal aspect of the femoral triangle (and beginning of the adductor canal) will be identified distal to the mid-thigh in the ipsilateral limb. Using ultrasound guidance, a standard Tuohy block needle will be advanced through a skin wheal of lidocaine until its tip is in the hypoechoic area immediately distal saphenous nerve adjacent to the femoral artery. Twenty milliliters of ropivacaine 0.5% will be injected in divided doses with repeated negative aspiration.",[15],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Rodney A Gabriel, MD","CONTACT","858-663-7747","ragabriel@health.ucsd.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","La Jolla","California","92037","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-117.2742,32.84727,{"lat":50,"lon":49},[53],{"name":54,"role":35,"phone":55,"phoneExt":26,"email":37},"Rodney Gabriel","8586637747",{"type":57,"investigatorFullName":54,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Associate Professor","100576406","phase-4-continuous-versus-single-injection-adductor-canal-blocks-for-outpatient-total-knee-arthroplasty-100576406",false,"NCT06784882","Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty","A Pilot Randomized Controlled Trial Assessing Pain and Opioid Outcomes Among Patients Undergoing Total Knee Arthroplasty Receiving 5-Day Outpatient Adductor Canal Continuous Versus Single Injection Blocks","Inclusion Criteria:\n\n1. Adult participants of at least 18 years of age\n2. Undergoing a primary, unilateral, total knee arthroplasty\n3. Planned single-injection adductor canal nerve block\n4. Weight \\> 50 kg (to minimize the risk of local anesthetic toxicity)\n\nExclusion Criteria:\n\n1. chronic opioid or tramadol use: daily oxycodone equivalents \\> 20 mg for \\> 4 weeks\n2. neuro-muscular deficit of the surgical limb\n3. moderate pain (NRS \\> 3) in an anatomic location other than the surgical site\n4. planned hospital admission following surgery\n5. history of opioid misuse\n6. those who lack capacity to complete informed consent\n7. inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)\n8. incarceration\n9. pregnancy\n10. allergy to amide local anesthetics","ALL","18 Years",{"count":69,"type":70},40,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.",[76,77],"Acute Postoperative Pain","Surgery",[79,80,81],"regional anesthesia","total knee arthroplasty","nerve block","2025-06-12",{"date":84,"type":85},"2025-06-17","ACTUAL",{"date":87,"type":85},"2025-06-01",{"date":89,"type":70},"2025-12-01",{"name":5,"class":6},1]