[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100455677":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":305,"collaborators":308,"id":335,"slug":336,"hasResults":337,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":23,"eligibilityCriteria":341,"healthyVolunteers":337,"sex":342,"minAge":343,"maxAge":344,"enrollmentInfo":345,"targetDuration":23,"studyType":348,"phases":349,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":42,"whyStopped":23,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":367},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inhaled Nitric Oxide (iNO) use","ACTIVE_COMPARATOR","The center will use iNO per their usual protocol in the initial resuscitation period (defined as birth through stabilization and CDH repair). No center will alter any component of their standard clinical practice guideline or protocol governing CDH care.",[13],"Drug: Inhaled Nitric Oxide (iNO) use",{"label":15,"type":10,"description":16,"interventionNames":17},"De-implementation of Inhaled Nitric Oxide (iNO) use","The center will stop using iNO in the initial resuscitation period (defined as birth through stabilization and CDH repair).",[18],"Other: De-implementation of Inhaled Nitric Oxide (iNO) use",[20,24],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},"DRUG",[9],null,{"type":6,"name":15,"description":16,"armGroupLabels":25,"otherNames":23},[15],[27],{"name":28,"affiliation":5,"role":29},"Matthew Harting, MD, MS, FACS","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":23,"email":34},"CONTACT","(713) 500-7398","Matthew.T.Harting@uth.tmc.edu",{"name":36,"role":32,"phone":37,"phoneExt":23,"email":38},"Ashley Ebanks","(832) 325-7234","Ashley.Harmon@uth.tmc.edu",[40,58,72,86,99,112,125,139,153,167,181,195,209,223,237,251,264,277,291],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Alabama & Children's Hospital of Alabama (UAB-CoA)","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-86.80249,33.52066,{"lat":52,"lon":51},[55],{"name":56,"role":32,"phone":23,"phoneExt":23,"email":57},"Scott Anderson, MD","Scott.Anderson@childrensal.org",{"facility":59,"status":42,"city":60,"state":61,"zip":62,"country":46,"countryCode":47,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"University of Arkansas & Arkansas Children's Hospital (UA-ACH)","Little Rock","Arkansas","72202",{"type":49,"coordinates":64},[65,66],-92.28959,34.74648,{"lat":66,"lon":65},[69],{"name":70,"role":32,"phone":23,"phoneExt":23,"email":71},"Sid Dassinger, MD","dassingermelvins@uams.edu",{"facility":73,"status":42,"city":74,"state":75,"zip":76,"country":46,"countryCode":47,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"University of California-Irvine & Children's Hospital of Orange County (UC-CHOC)","Irvine","California","92868",{"type":49,"coordinates":78},[79,80],-117.82311,33.66946,{"lat":80,"lon":79},[83],{"name":84,"role":32,"phone":23,"phoneExt":23,"email":85},"Yigit S Guner, MD, MS","YGuner@choc.org",{"facility":87,"status":42,"city":88,"state":75,"zip":89,"country":46,"countryCode":47,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"University of Southern California & Children's Hospital Los Angeles (USC-CHLA)","Los Angeles","90027",{"type":49,"coordinates":91},[92,93],-118.24368,34.05223,{"lat":93,"lon":92},[96],{"name":97,"role":32,"phone":23,"phoneExt":23,"email":98},"Rachel Chapman, MD","rachapman@chla.usc.edu",{"facility":100,"status":42,"city":101,"state":75,"zip":102,"country":46,"countryCode":47,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Stanford University & Lucile Packard Children's Hospital (Stanford-LPCH)","Palo Alto","94304",{"type":49,"coordinates":104},[105,106],-122.14302,37.44188,{"lat":106,"lon":105},[109],{"name":110,"role":32,"phone":23,"phoneExt":23,"email":111},"Krisa Van Meurs, MD","vanmeurs@stanford.edu",{"facility":113,"status":42,"city":114,"state":75,"zip":115,"country":46,"countryCode":47,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"University of California, San Diego & Rady Children's Hospital (UCSD-Rady)","San Diego","92123",{"type":49,"coordinates":117},[118,119],-117.16472,32.71571,{"lat":119,"lon":118},[122],{"name":123,"role":32,"phone":23,"phoneExt":23,"email":124},"Denise Suttner, MD","dsuttner@rchsd.org",{"facility":126,"status":42,"city":127,"state":128,"zip":129,"country":46,"countryCode":47,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"University of Colorado & Children's Hospital of Colorado (CU-CHC)","Aurora","Colorado","80045",{"type":49,"coordinates":131},[132,133],-104.83192,39.72943,{"lat":133,"lon":132},[136],{"name":137,"role":32,"phone":23,"phoneExt":23,"email":138},"Jason Gien, MD","Jason.Gien@childrenscolorado.org",{"facility":140,"status":42,"city":141,"state":142,"zip":143,"country":46,"countryCode":47,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Emory University & Children's Healthcare of Atlanta (CHOA)","Atlanta","Georgia","30322",{"type":49,"coordinates":145},[146,147],-84.38798,33.749,{"lat":147,"lon":146},[150],{"name":151,"role":32,"phone":23,"phoneExt":23,"email":152},"Sarah Keene, MD","skeene@emory.edu",{"facility":154,"status":42,"city":155,"state":156,"zip":157,"country":46,"countryCode":47,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Indiana University & Riley Children's Hospital (IU-RiCH)","Indianapolis","Indiana","46202",{"type":49,"coordinates":159},[160,161],-86.15804,39.76838,{"lat":161,"lon":160},[164],{"name":165,"role":32,"phone":23,"phoneExt":23,"email":166},"Brian W Gray, MD","graybw@iupui.edu",{"facility":168,"status":42,"city":169,"state":170,"zip":171,"country":46,"countryCode":47,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"University of Louisville & Norton Children's Hospital (UL-NCH)","Louisville","Kentucky","40202",{"type":49,"coordinates":173},[174,175],-85.75941,38.25424,{"lat":175,"lon":174},[178],{"name":179,"role":32,"phone":23,"phoneExt":23,"email":180},"Tiffany Wright, MD","tiffany.wright.1@louisville.edu",{"facility":182,"status":42,"city":183,"state":184,"zip":185,"country":46,"countryCode":47,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Harvard University & Boston Children's Hospital (Harvard-BCH)","Boston","Massachusetts","02115",{"type":49,"coordinates":187},[188,189],-71.05977,42.35843,{"lat":189,"lon":188},[192],{"name":193,"role":32,"phone":23,"phoneExt":23,"email":194},"Jill Zalieckas, MD, MPH","Jill.Zalieckas@childrens.harvard.edu",{"facility":196,"status":42,"city":197,"state":198,"zip":199,"country":46,"countryCode":47,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"University of Michigan & CS Mott Children's Hospital (UM-CSMott)","Ann Arbor","Michigan","48109",{"type":49,"coordinates":201},[202,203],-83.74088,42.27756,{"lat":203,"lon":202},[206],{"name":207,"role":32,"phone":23,"phoneExt":23,"email":208},"Erin Perrone, MD","eperrone@med.umich.edu",{"facility":210,"status":42,"city":211,"state":212,"zip":213,"country":46,"countryCode":47,"cosmosGeoPoint":214,"geoPoint":218,"contacts":219},"Randall Children's Hospital-Portland (RCH)","Portland","Oregon","97227",{"type":49,"coordinates":215},[216,217],-122.67621,45.52345,{"lat":217,"lon":216},[220],{"name":221,"role":32,"phone":23,"phoneExt":23,"email":222},"Cynthia Gindalewski, MD","cgingale@lhs.org",{"facility":224,"status":42,"city":225,"state":226,"zip":227,"country":46,"countryCode":47,"cosmosGeoPoint":228,"geoPoint":232,"contacts":233},"Medical University of South Carolina Children's Health (MUSC)","Charleston","South Carolina","29425",{"type":49,"coordinates":229},[230,231],-79.93275,32.77632,{"lat":231,"lon":230},[234],{"name":235,"role":32,"phone":23,"phoneExt":23,"email":236},"Laura E Hollinger, MD","hollingl@musc.edu",{"facility":238,"status":42,"city":239,"state":240,"zip":241,"country":46,"countryCode":47,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"University of Tennessee & LeBonheur Children's Hospital (UT-LBCH)","Memphis","Tennessee","38105",{"type":49,"coordinates":243},[244,245],-90.04898,35.14953,{"lat":245,"lon":244},[248],{"name":249,"role":32,"phone":23,"phoneExt":23,"email":250},"Mark F Weems, MD","mweems@uthsc.edu",{"facility":252,"status":42,"city":253,"state":240,"zip":254,"country":46,"countryCode":47,"cosmosGeoPoint":255,"geoPoint":259,"contacts":260},"Vanderbilt University & Vanderbilt University Medical Center (VUMC)","Nashville","37232",{"type":49,"coordinates":256},[257,258],-86.78444,36.16589,{"lat":258,"lon":257},[261],{"name":262,"role":32,"phone":23,"phoneExt":23,"email":263},"Emily A Morris, MD","emily.a.morris@vumc.org",{"facility":265,"status":42,"city":266,"state":267,"zip":268,"country":46,"countryCode":47,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"The University of Texas Health Science Center at Houston","Houston","Texas","77030",{"type":49,"coordinates":270},[271,272],-95.36327,29.76328,{"lat":272,"lon":271},[275,276],{"name":28,"role":32,"phone":33,"phoneExt":23,"email":34},{"name":36,"role":32,"phone":37,"phoneExt":23,"email":38},{"facility":278,"status":42,"city":279,"state":280,"zip":281,"country":46,"countryCode":47,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"University of Utah & Primary Children's Hospital (Utah-PCH)","Salt Lake City","Utah","84108",{"type":49,"coordinates":283},[284,285],-111.89105,40.76078,{"lat":285,"lon":284},[288],{"name":289,"role":32,"phone":23,"phoneExt":23,"email":290},"Katie W Russell, MD","Katie.Russell@hsc.utah.edu",{"facility":292,"status":42,"city":293,"state":294,"zip":295,"country":46,"countryCode":47,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"University of Washington & Seattle Children's Hospital (UW-SCH)","Seattle","Washington","98105",{"type":49,"coordinates":297},[298,299],-122.33207,47.60621,{"lat":299,"lon":298},[302],{"name":303,"role":32,"phone":23,"phoneExt":23,"email":304},"Rebecca Stark, MD","Rebecca.stark@seattlechildrens.org",{"type":29,"investigatorFullName":306,"investigatorTitle":307,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Matthew T Harting","Associate Professor",[309,311,313,314,315,316,317,319,321,322,324,325,326,327,329,331,332,333],{"name":238,"class":310},"UNKNOWN",{"name":312,"class":6},"Children's Hospital of Orange County",{"name":224,"class":310},{"name":196,"class":310},{"name":210,"class":310},{"name":100,"class":310},{"name":318,"class":6},"Rady Children's Hospital, San Diego",{"name":320,"class":6},"Boston Children's Hospital",{"name":154,"class":310},{"name":323,"class":6},"Norton Children's Hospital",{"name":278,"class":310},{"name":292,"class":310},{"name":41,"class":310},{"name":328,"class":6},"University of Arkansas",{"name":330,"class":6},"Vanderbilt University Medical Center",{"name":87,"class":310},{"name":140,"class":310},{"name":334,"class":6},"Children's Hospital Colorado","100455677","phase-4-de-implementing-inhaled-nitric-oxide-for-congenital-diaphragmatic-hernia-100455677",false,"NCT05213676","De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia","Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) - The \"NoNO Trial\" - a Multi-center, De-implementation, Stepped-wedge, Cluster-randomized Trial Within an Established Collaborative","Inclusion Criteria:\n\n* Postnatal, live born neonates with CDH\n\n  a. Presence of associated or additional anomalies is acceptable for inclusion\n* Bochdalek hernia location (right or left)\n* Diagnosed prior to 1 month of life\n* Born within or transferred to (within 1 week of life) a CDHSG member center participating in the trial\n\nExclusion Criteria:\n\n* CDH diagnosis after 1 month of age\n* Morgagni diaphragmatic hernia (central \u002F anterior-medial diaphragmatic defect location)\n* Transferred to a CDH Study Group (CDHSG) member center after 1 week of life\n* Patients without potential access to iNO","ALL","0 Months","1 Month",{"count":346,"type":347},600,"ESTIMATED","INTERVENTIONAL",[350],"PHASE4","The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation\u002Fstabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and\u002For mortality, as well as ECLS use, mortality, and\u002For oxygenation in congenital diaphragmatic hernia (CDH) newborns and to establish the cost-effectiveness of de-implementing iNO as a therapy in the postnatal resuscitation\u002Fstabilization phase of CDH management, which will be assessed as the incremental health system costs (savings) per prevented ECLS use and\u002For death.",[353],"Congenital Diaphragmatic Hernia",[355,356,357],"CDH","Inhaled Nitric Oxide","Pulmonary Hypertension","2026-02-04",{"date":360,"type":361},"2026-02-09","ACTUAL",{"date":363,"type":361},"2025-11-01",{"date":365,"type":347},"2031-04-30",{"name":5,"class":6},19]