[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490250":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":38,"locations":44,"responsibleParty":59,"collaborators":42,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":42,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":42,"enrollmentInfo":70,"targetDuration":42,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":47,"whyStopped":42,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Louisiana State University Health Sciences Center in New Orleans","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants with no obstruction of the lacrimal system","EXPERIMENTAL","Patients will have received a drop of Proparacaine Hydrocholoride 0.5% ophthalmic solution in one eye and a drop of BSS in the other eye prior to probing and irrigation.",[13,14],"Drug: Proparacaine Hydrochloride ophthalmic solution, USP 0.5%","Drug: Balanced salt solution",{"label":16,"type":10,"description":17,"interventionNames":18},"Participants with obstruction of the lacrimal system","Participants who have a blockage in their tear drainage system on probing and irrigation. Participants will have received a drop of Proparacaine Hydrocholoride 0.5% ophthalmic solution in one eye and a drop of BSS in the other eye prior to probing and irrigation.",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Proparacaine Hydrochloride ophthalmic solution, USP 0.5%","One drop instilled in one eye, randomly chosen, as topical anesthetic",[9,16],[26],"Alcaine",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Balanced salt solution","One drop instilled in one eye, randomly chosen, as control placebo",[9,16],[32],"BSS",[34],{"name":35,"affiliation":36,"role":37},"Austin M Pharo, MD","LSU Health Sciences Center","PRINCIPAL_INVESTIGATOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","(504) 568-3156",null,"apharo@lsuhsc.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":42},"Louisiana State University Health Sciences Center","RECRUITING","New Orleans","Louisiana","70112","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-90.07507,29.95465,{"lat":57,"lon":56},{"type":60,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100490250","phase-4-does-topical-ophthalmic-proparacaine-05-prior-to-probing-and-irrigation-decrease-pain-100490250",false,"NCT05663684","Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?","Does Administration of Proparacaine Hydrochloride 0.5% Ophthalmic Solution Prior to Canalicular Probing and Irrigation Decrease Patient Discomfort?","Inclusion Criteria:\n\n* Participants of any sex aged 18 years or older\n* Signs and symptoms of epiphora which necessitate performance of a diagnostic probing and irrigation of the bilateral lower eyelid lacrimal drainage system at Louisiana State University Health Sciences Center or any of the listed physician offices who present with a complaint of epiphora from either eye\n\nExclusion Criteria:\n\n* A known allergy to topical proparacaine hydrochloride\n* Known pre-existing scarring, surgery, radiation to the nasolacrimal system\n* Presence of blockage and or reflux on probing and irrigation of either side\n* Cognitive Impairment","ALL","18 Years",{"count":71,"type":72},145,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves participant comfort during the procedure. To date, there have been no formal studies evaluating the possible benefit of this pretreatment.\n\nMethods: Participants 18 years and older who present to the Louisiana State University or associated outpatient ophthalmology clinic(s) with a complaint of epiphora (excessive tearing) who necessitate bilateral lower lid probing and irrigation of the lacrimal drainage system will be enrolled in the study. One eye will be randomized to receive a drop of the anesthetic Proparacaine hydrochloride 0.5% and the other eye will receive a control drop of Balanced Salt Solution (BSS). Probing and irrigation will then be performed in the usual fashion. The participant will then be questioned via survey on a pain scale of 1-5 as to the amount of subjective pain experienced on each side during the procedure.\n\nExpected Results: Investigators expect participants will experience statistically significantly less pain in eyes that have received a drop of Proparacaine hydrochloride 0.5% prior to performance of probing and irrigation compared to the eyes which have received the control drop.",[78,79,80],"Epiphora","Dacryostenosis","Dacryocystitis",[82,83],"Nasolacrimal duct obstruction","Probe and irrigation","2022-12-15",{"date":86,"type":87},"2022-12-23","ACTUAL",{"date":89,"type":87},"2020-06-30",{"date":91,"type":72},"2023-01-31",{"name":5,"class":6},1]