[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610626":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":38,"centralContacts":42,"locations":33,"responsibleParty":48,"collaborators":50,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":33,"enrollmentInfo":64,"targetDuration":33,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":75,"whyStopped":33,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":33},{"fullName":5,"class":6},"Radboud University Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Doxycycline in combination with Hydroxychloroquine","EXPERIMENTAL","Doxycycline (standard of care) in combination with Hydroxychloroquine 2 x 200 mg (two times a day one tablet).",[13,14],"Drug: Hydroxychloroquin","Drug: Doxycycline",{"label":16,"type":17,"description":18,"interventionNames":19},"Doxycycline in combination with placebo","PLACEBO_COMPARATOR","Doxycycline (standard of care) in combination with Placebo (two times a day one tablet).",[20,14],"Drug: Placebo",[22,29,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Hydroxychloroquin","Added to the standard of care for Lyme Disease",[9],[28],"Plaquenil",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Placebo","Standard of care in combination with placebo",[16],null,{"type":23,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Doxycycline","Standard of care",[9,16],[39],{"name":40,"affiliation":5,"role":41},"Hadewych Ter Hofstede, Dr.","PRINCIPAL_INVESTIGATOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":33,"email":47},"Hadewych ter Hofstede, Dr.","CONTACT","+3124361819","hadewych.terhofstede@radboudumc.nl",{"type":49,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR",[51],{"name":52,"class":53},"Ministerie van Volksgezondheid, Welzijn en Sport","UNKNOWN","100610626","phase-4-doxycycline-boosted-therapy-in-lyme-borreliosis-dobo-study-100610626",false,"NCT07230028","Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.","A Monocenter, Randomized, Double Blind Pilot Study Comparing Doxycycline in Combination With Hydroxychloroquine Treatment Versus Doxycycline Monotherapy in Patients With Long-Term Complaints Attributed to Lyme Borreliosis.","DoBo","Inclusion Criteria:\n\n* Patients who are 18 years of age or older\n* Patients with probable or possible signs and symptoms attributed to Lyme borreliosis\n* Patients with probable or possible post Lyme treatment Lyme borreliosis syndrome (PTLBS)\n* Males or non-pregnant females (who must agree to use barrier methods of contraception during the study therapy period, women of childbearing age must have a negative urine pregnancy or serum test at baseline).\n\nExclusion Criteria:\n\n* Known contra-indication for used study medication.\n* Women who are pregnant or lactating","ALL","18 Years",{"count":65,"type":66},50,"ESTIMATED","INTERVENTIONAL",[69],"PHASE4","The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are:\n\nDoes addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis.\n\nParticipants will:\n\nTake hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.",[72],"Lyme Borreliosis, Nervous System",[74],"Hydroxychloroquine","NOT_YET_RECRUITING","2025-11-14",{"date":78,"type":79},"2025-11-17","ACTUAL",{"date":81,"type":66},"2026-03-01",{"date":83,"type":66},"2027-11-01",{"name":5,"class":6}]