[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100572833":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":38,"centralContacts":46,"locations":56,"responsibleParty":281,"collaborators":283,"id":298,"slug":299,"hasResults":300,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":30,"eligibilityCriteria":304,"healthyVolunteers":300,"sex":305,"minAge":306,"maxAge":307,"enrollmentInfo":308,"targetDuration":30,"studyType":311,"phases":312,"briefSummary":314,"conditions":315,"keywords":320,"overallStatus":81,"whyStopped":30,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":334},{"fullName":5,"class":6},"Westat","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"On-demand doxyPEP","EXPERIMENTAL","Participants will take by mouth doxycycline 200 mg as soon as possible and within 72 hours after any condomless oral, 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Chicago","Chicago","Illinois","60612",{"type":66,"coordinates":153},[154,155],-87.65005,41.85003,{"lat":155,"lon":154},[158,162],{"name":159,"role":49,"phone":160,"phoneExt":30,"email":161},"Rachel Jackson","312-996-6018","rjacks34@uic.edu",{"name":163,"role":78,"phone":30,"phoneExt":30,"email":30},"Kelly Bojan",{"facility":165,"status":59,"city":166,"state":167,"zip":168,"country":63,"countryCode":64,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Tulane University","New Orleans","Louisiana","70112",{"type":66,"coordinates":170},[171,172],-90.07507,29.95465,{"lat":172,"lon":171},[175,179],{"name":176,"role":49,"phone":177,"phoneExt":30,"email":178},"Leslie Kozina","504-988-5348","lkozina@tulane.edu",{"name":180,"role":78,"phone":30,"phoneExt":30,"email":30},"Tina Simpson",{"facility":182,"status":59,"city":183,"state":184,"zip":185,"country":63,"countryCode":64,"cosmosGeoPoint":186,"geoPoint":190,"contacts":191},"Johns Hopkins 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Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":288,"class":286},"National Institute of Allergy and Infectious Diseases (NIAID)",{"name":290,"class":286},"National Institute on Drug Abuse (NIDA)",{"name":292,"class":286},"National Institute of Mental Health (NIMH)",{"name":294,"class":6},"Florida State University",{"name":296,"class":297},"The Office of the Director, National Institutes of Health (NIH)","UNKNOWN","100572833","phase-4-doxycycline-prophylaxis-for-prevention-of-sexually-transmitted-infections-100572833",false,"NCT06738407","Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections","Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States","Inclusion Criteria:\n\n* Age 13-29 years, inclusive;\n* Self-reports GC, CT, and\u002For early syphilis diagnosis in the 12 months prior to screening;\n* Self-reports condomless (oral, vaginal, and\u002For anal) intercourse at least once in the 30 days prior to screening\n* Is at least 45 kilograms (99.2 pounds) in weight\n* Fluent in English (able to read, speak, and understand English);\n* Willing to undergo all required study procedures; and\n* Willing to provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Is male;\n* Is pregnant, breastfeeding, or planning to become pregnant in the next 12 months;\n* Documented history of tetracycline allergy or self-reports an allergy to tetracyclines;\n* Current or anticipated use of a medication (e.g., barbiturates, phenytoin, lithium, carbamazepine, systemic retinoids, warfarin) with a contraindicated interaction to doxycycline ;\n* Current or planned use of doxycycline for a prolonged period (\\> 2 weeks) in the 30 days prior to enrollment, including current prescription for doxycycline for STI prophylaxis;\n* Prolonged antibiotic use (\\> 2 weeks) within the last 30 days prior to enrollment;\n* Co-enrollment in any other concurrent interventional research or studies that may interfere with this study, such as an STI prevention trial, unless approved by Protocol Team in writing;\n* Does not have consistent access (or anticipated weekly access for 52 weeks of survey completion) to smartphone that can access the HMP app; or\n* Any other medical condition, medical\u002Fbehavioral intervention, or other conditions that, in the opinion of the clinical site Project Lead (PL)\u002FInvestigator of Record (IoR) or designee, could interfere with adherence to study procedures or compromise interpretation of study results.","FEMALE","13 Years","29 Years",{"count":309,"type":310},760,"ESTIMATED","INTERVENTIONAL",[313],"PHASE4","The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy.",[316,317,318,319],"Gonorrhea","Chlamydia","Syphilis","Sexually Transmitted Infections (STIs)",[321,322,323,324],"Sexually Transmitted Infections","STIs","Doxycycline Prophylaxis","Doxycycline","2026-05-12",{"date":327,"type":328},"2026-05-15","ACTUAL",{"date":330,"type":328},"2026-02-27",{"date":332,"type":310},"2028-06-15",{"name":5,"class":6},13]