[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616486":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":182,"collaborators":186,"id":197,"slug":198,"hasResults":199,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":199,"sex":205,"minAge":206,"maxAge":207,"enrollmentInfo":208,"targetDuration":26,"studyType":211,"phases":212,"briefSummary":214,"conditions":215,"keywords":218,"overallStatus":222,"whyStopped":26,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":232},{"fullName":5,"class":6},"Korea University Anam Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group (Doxycycline)","EXPERIMENTAL","Participants will receive oral doxycycline (4 mg\u002Fkg\u002Fday divided into 2 doses for weight ≤45 kg; 100 mg BID for weight \\>45 kg). The standard treatment duration is 7 days, which may be extended up to 14 days based on clinical response.",[13],"Drug: Doxycycline",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group (Azithromycin)","ACTIVE_COMPARATOR","Participants will receive oral azithromycin according to the standard 5-day regimen (10 mg\u002Fkg on Day 1, followed by 5 mg\u002Fkg on Days 2-5).",[19],"Drug: Azithromycin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Doxycycline","Intervention Group (Doxycycline): Participants will receive oral doxycycline (4 mg\u002Fkg\u002Fday divided into 2 doses for weight ≤45 kg; 100 mg BID for weight \\>45 kg). The standard treatment duration is 7 days, which may be extended up to 14 days based on clinical response.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Azithromycin","Control Group (Azithromycin): Participants will receive oral azithromycin according to the standard 5-day regimen (10 mg\u002Fkg on Day 1, followed by 5 mg\u002Fkg on Days 2-5).\n\nRescue Therapy Protocol: To ensure patient safety, a standardized \"rescue therapy\" protocol is implemented. Participants in the Control group who fail to demonstrate clinical improvement at the 48-72 hour assessment-defined as persistent fever (≥38.0°C) or clinical deterioration-will be immediately switched to doxycycline. Consistent with the intention-to-treat principle, these cases will be classified as treatment failures for the primary efficacy analysis.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Young June Choe, MD","CONTACT","+82-10-5943-0133","choey@korea.ac.kr",[38,52,64,76,88,100,109,121,130,138,147,156,165,173],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Department of Pediatrics, Pusan National University School of Medicine, Pusan National University Children's Hospital, Yangsan, Republic of Korea","Busan","South Korea",{"type":43,"coordinates":44},"Point",[45,46],129.03004,35.10168,{"lat":46,"lon":45},[49],{"name":50,"role":34,"phone":35,"phoneExt":26,"email":51},"Kyo Jin Jo, MD","godjkj@nate.com",{"facility":53,"status":26,"city":54,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Department of Pediatrics, Gyeongsang National University College of Medicine, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea","Changwon",{"type":43,"coordinates":56},[57,58],128.68111,35.22806,{"lat":58,"lon":57},[61],{"name":62,"role":34,"phone":35,"phoneExt":26,"email":63},"Kyung-Ran Kim, MD","kkran82@gmail.com",{"facility":65,"status":26,"city":66,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Department of Pediatrics, Chosun University College of Medicine, Chosun University Hospital, Gwangju, Republic of Korea","Gwangju",{"type":43,"coordinates":68},[69,70],126.91556,35.15472,{"lat":70,"lon":69},[73],{"name":74,"role":34,"phone":35,"phoneExt":26,"email":75},"Gahee Kim, MD","pauelf01@gmail.com",{"facility":77,"status":26,"city":78,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Department of Pediatrics, Jeju National University School of Medicine, Jeju National University Hospital, Jeju, Republic of Korea","Jeju City",{"type":43,"coordinates":80},[81,82],126.52194,33.50972,{"lat":82,"lon":81},[85],{"name":86,"role":34,"phone":35,"phoneExt":26,"email":87},"Jae Hong Choi, MD","pedidongs@gmail.com",{"facility":89,"status":26,"city":90,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Department of Pediatrics, CHA University School of Medicine, CHA Bundang Medical Center, Seongnam, Republic of Korea","Seongnam",{"type":43,"coordinates":92},[93,94],127.7548,36.4052,{"lat":94,"lon":93},[97],{"name":98,"role":34,"phone":35,"phoneExt":26,"email":99},"Taek Jin Lee, MD","bjloveu@daum.net",{"facility":101,"status":26,"city":90,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":102,"geoPoint":104,"contacts":105},"Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea",{"type":43,"coordinates":103},[93,94],{"lat":94,"lon":93},[106],{"name":107,"role":34,"phone":35,"phoneExt":26,"email":108},"Hyunju Lee, MD","hyunjulee@snu.ac.kr",{"facility":110,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Department of Pediatrics, College of Medicine, The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Republic of Korea","Seoul",{"type":43,"coordinates":113},[114,115],126.9784,37.566,{"lat":115,"lon":114},[118],{"name":119,"role":34,"phone":35,"phoneExt":26,"email":120},"Ui Yoon Choi, MD","uiyoon@catholic.ac.kr",{"facility":122,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":123,"geoPoint":125,"contacts":126},"Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Republic of Korea",{"type":43,"coordinates":124},[114,115],{"lat":115,"lon":114},[127],{"name":128,"role":34,"phone":35,"phoneExt":26,"email":129},"Hyun Mi Kang, MD","pedhmk@catholic.ac.kr",{"facility":131,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":132,"geoPoint":134,"contacts":135},"Department of Pediatrics, Eulji University School of Medicine, Eulji University Hospital, Seoul, Republic of Korea",{"type":43,"coordinates":133},[114,115],{"lat":115,"lon":114},[136],{"name":137,"role":34,"phone":35,"phoneExt":26,"email":26},"Byung Wook Eun, MD",{"facility":139,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":140,"geoPoint":142,"contacts":143},"Department of Pediatrics, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea",{"type":43,"coordinates":141},[114,115],{"lat":115,"lon":114},[144],{"name":145,"role":34,"phone":35,"phoneExt":26,"email":146},"Youn Young Choi, MD","cyypedr@korea.ac.kr",{"facility":148,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":149,"geoPoint":151,"contacts":152},"Department of Pediatrics, Korea University College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea",{"type":43,"coordinates":150},[114,115],{"lat":115,"lon":114},[153],{"name":154,"role":34,"phone":35,"phoneExt":26,"email":155},"Yoon Sun Yoon, MD","yhappy815@gmail.com",{"facility":157,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":158,"geoPoint":160,"contacts":161},"Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea",{"type":43,"coordinates":159},[114,115],{"lat":115,"lon":114},[162],{"name":163,"role":34,"phone":35,"phoneExt":26,"email":164},"Ki Wook Yun, MD","pedwilly@snu.ac.kr",{"facility":157,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":166,"geoPoint":168,"contacts":169},{"type":43,"coordinates":167},[114,115],{"lat":115,"lon":114},[170],{"name":171,"role":34,"phone":35,"phoneExt":26,"email":172},"Bin Ahn, MD","ahnnybinny@gmail.com",{"facility":174,"status":26,"city":111,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":175,"geoPoint":177,"contacts":178},"Department of Pediatrics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea",{"type":43,"coordinates":176},[114,115],{"lat":115,"lon":114},[179],{"name":180,"role":34,"phone":35,"phoneExt":26,"email":181},"Doo Ri Kim, MD","doori756.kim@samsung.com",{"type":183,"investigatorFullName":184,"investigatorTitle":185,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Young June Choe","Professor",[187,190,193,195],{"name":188,"class":189},"Korea Society of Pediatric Infectious Diseases","UNKNOWN",{"name":191,"class":192},"National Institute of Health, Korea","OTHER_GOV",{"name":194,"class":189},"Korea Disease Control and Prevention Agency",{"name":196,"class":189},"DT&CRO","100616486","phase-4-doxycycline-vs-macrolide-for-mrmp-domino-100616486",false,"NCT07306234","Doxycycline vs. Macrolide for MRMP (DOMINO)","Efficacy and Safety of Doxycycline Versus Macrolides for Mycoplasma Pneumoniae Infection in Children (DOMINO): A Protocol for a Multicenter, Randomized, Open-Label, Superiority Trial","DOMINO","Inclusion Criteria:\n\n* Age: 3 to 17 years at the time of enrollment.\n* Diagnosis: Clinically diagnosed CAP characterized by respiratory symptoms (e.g., fever, cough, auscultatory findings) and chest X-ray confirming pulmonary infiltrates.\n* Pathogen: Confirmed MP M. pneumoniae infection via PCR OR strongly suspected infection based on clinical features and epidemiological grounds (e.g., outbreaks among classmates, poor response to prior non-macrolide antibiotics).\n* Resistance: Suspected macrolide-resistant M. pneumoniae (MRMP) infection (e.g., during a reported local epidemic of MRMP).\n* Timing: Ability to register and initiate the study drug within 72 hours of symptom onset.\n\nExclusion Criteria:\n\n* Prior use of tetracyclines, macrolides, or quinolones for the current illness.\n* Complicated pneumonia (e.g., necrosis, empyema, lung abscess) or severe pneumonia requiring immediate intensive care or exhibiting hypoxia (SpO₂ \\\u003C90%).\n* Hypersensitivity or contraindications to macrolides or tetracyclines.\n* Severe immunocompromised state or severe underlying lung disease.\n* Severe hepatic impairment (AST\u002FALT \\>3x upper limits) or severe renal impairment.","ALL","3 Years","17 Years",{"count":209,"type":210},208,"ESTIMATED","INTERVENTIONAL",[213],"PHASE4","The goal of this clinical trial is to learn if doxycycline works to treat pneumonia in children. It focuses on children with Mycoplasma pneumoniae infection that may not respond to standard medicines. The main questions it aims to answer are:\n\n* Does doxycycline stop fevers faster than azithromycin?\n* Is doxycycline safe for children, specifically regarding tooth color changes?\n\nResearchers will compare doxycycline to azithromycin to see if doxycycline works better to treat this type of pneumonia.\n\nParticipants will:\n\n* Take either doxycycline or azithromycin by mouth for 7 to 14 days.\n* Check their body temperature to see when their fever goes away.\n* Visit the hospital to check for any medical problems.\n* Have their teeth checked for color changes 28 days after starting the medicine.",[216,217],"Mycoplasma Pneumoniae","Mycoplasma Pneumoniae Pneumonia",[219,220,221],"Mycoplasma pneumoniae","Macrolide resistance","Children","NOT_YET_RECRUITING","2025-12-24",{"date":225,"type":226},"2025-12-29","ACTUAL",{"date":228,"type":210},"2026-03-01",{"date":230,"type":210},"2029-02-28",{"name":184,"class":6},14]