[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630533":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":34,"centralContacts":28,"locations":39,"responsibleParty":86,"collaborators":89,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":95,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":28,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":28,"overallStatus":113,"whyStopped":28,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Goethe University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Psychopharmacological treatment","EXPERIMENTAL","Participants receive psychopharmacological treatment according to guideline-based clinical practice.",[13],"Drug: Psychopharmacological treatment",{"label":15,"type":10,"description":16,"interventionNames":17},"Psychotherapeutical group treatment","Participants receive manualized cognitive-behavioral group psychotherapy.",[18],"Behavioral: Cognitive-behavioral group treatment (CBGT-D)",{"label":20,"type":10,"description":21,"interventionNames":22},"Combined intervention","Combination of the aforementioned psychopharmacological and cognitive-behavioral group treatment.",[13,18],[24,29],{"type":25,"name":9,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Participants will receive outpatient treatment with escitalopram. Treatment will be initiated at 5 mg\u002Fday for three days and increased to a target dose of 10 mg\u002Fday. Clinical re-evaluations will take place after two and four weeks. In case of insufficient clinical response, the dose may be increased to 15 mg\u002Fday in accordance with guideline recommendations.",[20,9],null,{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":28},"BEHAVIORAL","Cognitive-behavioral group treatment (CBGT-D)","Consisting of a group treatment of the same time frame as the psychopharmacological treatment and includes the following components: psychoeducation, behavioral activation, cognitive restructuring, social problem-solving, homework assignments and relapse prevention.",[20,15],[35],{"name":36,"affiliation":37,"role":38},"Igor Nenadic, Prof. Dr.","Philipps University Marburg","PRINCIPAL_INVESTIGATOR",[40,61,72],{"facility":41,"status":28,"city":42,"state":28,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Clinical Psychology and Psychotherapy","Frankfurt","60486","Germany","DE",{"type":47,"coordinates":48},"Point",[49,50],10.53333,49.68333,{"lat":50,"lon":49},[53,58],{"name":54,"role":55,"phone":56,"phoneExt":28,"email":57},"Ulrich Stangier, Prof. Dr.","CONTACT","+496979823842","stangier@psych.uni-frankfurt.de",{"name":59,"role":55,"phone":28,"phoneExt":28,"email":60},"Mareike Ebert, M.Sc.","m.ebert@psych.uni-frankfurt.de",{"facility":62,"status":28,"city":42,"state":28,"zip":63,"country":44,"countryCode":45,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Department of Psychiatry, Psychosomatics and Psychotherapy","60528",{"type":47,"coordinates":65},[49,50],{"lat":50,"lon":49},[68],{"name":69,"role":55,"phone":70,"phoneExt":28,"email":71},"Oliver Grimm, PD Dr.","+6906963012224","O.Grimm@med.uni-frankfurt.de",{"facility":73,"status":28,"city":74,"state":28,"zip":75,"country":44,"countryCode":45,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Department of Psychiatry and Psychotherapy","Marburg","35039",{"type":47,"coordinates":77},[78,79],8.77069,50.80904,{"lat":79,"lon":78},[82],{"name":83,"role":55,"phone":84,"phoneExt":28,"email":85},"Igor Nenadić, Prof. Dr.","+4964215865002","nenadic@uni-marburg.de",{"type":38,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Prof. Dr. Ulrich Stangier","Goethe Research Professorship",[90,92],{"name":91,"class":6},"Johann Wolfgang Goethe University Hospital",{"name":37,"class":6},"100630533","phase-4-dynamic-networks-in-depression-treatment-mechanisms-of-change-in-pharmacological-psychological-and-combined-treatment-of-depression-100630533",false,"NCT07488910","Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression","Veränderungen Dynamischer Symptom-Netzwerke Unter Pharmakologischer, Psychotherapeutischer Und Kombinierter Behandlung Bei Depression (DYNDET)","DYNDET","Inclusion Criteria:\n\n1. Depressive disorder (mild to moderate symptom severity)\n2. 18-65 years\n3. must own a smartphone with internet access\n\nExclusion Criteria:\n\n1. severe depressive episode\n2. acute suicidality,\n3. bipolar disorder,\n4. substance use disorder\n5. psychotic depression\n6. severe medical or neurological illness\n7. insufficient german language skills\n8. concurrent psychotherapeutic treatment\n9. conditions that may interfere with fMRI","ALL","18 Years","65 Years",{"count":105,"type":106},90,"ESTIMATED","INTERVENTIONAL",[109],"PHASE4","This study investigates how antidepressant pharmacotherapy, cognitive-behavioral therapy, or their combination modulate the temporal dynamics and connectivity of depressive symptom networks. Using intensive longitudinal ecological momentary assessment data, the trial examines treatment-specific changes in symptom interactions.\n\nBy applying network-based analytic approaches, the study aims to elucidate differential and potentially complementary mechanisms of change across treatment modalities. Findings may contribute to more informed and individualized treatment strategies for major depressive disorder.",[112],"Depression - Major Depressive Disorder","NOT_YET_RECRUITING","2026-03-18",{"date":116,"type":117},"2026-03-23","ACTUAL",{"date":119,"type":106},"2026-02",{"date":121,"type":106},"2028-01",{"name":5,"class":6},3]