[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621523":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":80,"whyStopped":26,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Sir Mortimer B. Davis - Jewish General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Arm","EXPERIMENTAL","Oral aprepitant 80mg within an hour of induction",[13],"Drug: Aprepitant",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Arm","PLACEBO_COMPARATOR","Placebo capsule within an hour of induction",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Aprepitant","Participants will be randomly assigned to the intervention or control group in a 1:1 ratio. Oral aprepitant of 80mg will be administered within an hour of induction for an otological surgery.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Participants will be randomly assigned to the intervention or control group in a 1:1 ratio. An oral placebo capsule will be administered within an hour of induction for an otological surgery.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Emily Ajit-Roger, MD","CONTACT","514 340-7581","emily.ajit-roger@mail.mcgill.ca",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Jewish General Hospital","Montreal","Quebec","H3T 1E2","Canada","CA",{"type":46,"coordinates":47},"Point",[48,49],-73.58781,45.50884,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Emily Kay-Rivest","Otolaryngologist","100621523","phase-4-effect-of-aprepitant-on-post-operative-nausea-and-vomiting-in-otologic-surgery-100621523",false,"NCT07371728","Effect of Aprepitant on Post-operative Nausea and Vomiting in Otologic Surgery","Effect of Aprepitant on Post-operative Nausea and Vomiting in Otologic Surgery: A Pilot Randomized-Controlled Trial","Inclusion Criteria:\n\n* Adult patients undergoing middle ear surgery including tympanoplasty with or without ossicular chain reconstruction, tympanomastoidectomy or stapedectomy\n* Patient using a hormonal contraceptive will be included, but warned aprepitant may reduce the efficacy of hormonal contraception thus an alternative or backup contraceptive methods should be used for one month after surgery\n\nExclusion Criteria:\n\n* Children (\\\u003C18 years old)\n* Patients unable to complete the post-procedure questionnaire (either due to time constraints, neurocognitive impairment, etc.)\n* Patients taking concomitant medications that are substrates, inhibitors or inducers of CYP3A4 or CYP2CP that are at risk of having a clinically significant effect\n* Patients with a history of hypersensitivity reaction to any of the medications used in the study\n* Patients who are pregnant or breastfeeding\n* Patients unable to receive general anesthesia (i.e. procedures performed under local anesthesia with or without sedation)\n* Patients with severe hepatic insufficiency (Child-Pugh class C)\n* Patients on total intravenous anesthesia (TIVA)","ALL","18 Years",{"count":67,"type":68},100,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","This project is being carried out to study the use of a medication to reduce nausea and vomiting after ear surgery.",[74],"Otologic Disease",[76,77,78,79],"aprepitant","nausea","vomiting","otologic surgery","NOT_YET_RECRUITING","2026-01-18",{"date":83,"type":84},"2026-01-28","ACTUAL",{"date":86,"type":68},"2026-06-01",{"date":88,"type":68},"2028-06-01",{"name":5,"class":6},1]