[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582509":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":54,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"VZW Cardiovascular Research Center Aalst","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","IV 0.9% NaCl (5 ml)",[13],"Drug: Saline (NaCl)",{"label":15,"type":16,"description":17,"interventionNames":18},"Beta-blocker","ACTIVE_COMPARATOR","IV metoprolol (5 ml of 1 mg\u002Fml solution for injection)",[19],"Drug: Metoprolol Tartrate",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Saline (NaCl)",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Metoprolol Tartrate","Metoprolol Tartrate (5 ml of 1 mg\u002Fml solution for injection)",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Adriaan Wilgenhof, MD","CONTACT","+32 53 72 44 39","adriaan.wilgenhof@azorg.be",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},"Thabo Mahendiran, MD","thabo.mahendiran@doctors.org.uk",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":25},"OLV Cardiovascular Center Aalst","RECRUITING","Aalst","Flanders","9300","Belgium","BE",{"type":49,"coordinates":50},"Point",[51,52],4.0355,50.93604,{"lat":52,"lon":51},{"type":55,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100582509","phase-4-effect-of-beta-blockers-on-coronary-flow-and-resistance-in-patients-with-anoca-100582509",false,"NCT06864234","Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA","Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA: a Randomised, Placebo-controlled, Mechanistic Study","BEACON","Inclusion Criteria:\n\n* Patients undergoing diagnostic coronary angiography for suspected angina pectoris who are found to have ANOCA i.e. an FFR \\>0.80 and no diameter stenosis \\>50%\n* Normal, TIMI 3 flow at angiography\n* Stable haemodynamics\n\nExclusion Criteria:\n\n* Clinical signs or symptoms of congestive heart failure\n* Severe valvular heart disease requiring either surgical or percutaneous intervention\n* History of coronary artery bypass grafting\n* Tortuous coronary anatomy in which wire manipulation could be complex\n* Heart rate \\\u003C60 beats per minute\n* Systolic blood pressure \\\u003C100 mmHg\n* Unable to give consent\n* LVEF\\\u003C40%",true,"ALL","18 Years",{"count":68,"type":69},46,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).\n\nThe main questions it aims to answer are:\n\n* Do beta-blockers improve coronary blood flow in patients with ANOCA?\n* Do beta-blockers reduce coronary microvascular resistance in these patients?\n\nResearchers will compare a beta-blocker to a placebo to see if the medication has measurable effects on coronary circulation.\n\nParticipants will:\n\n* Receive a beta-blocker or a placebo\n* Undergo specialized heart tests (such as coronary flow and resistance measurements) before and after treatment.",[75,76,77],"Coronary Arterial Disease (CAD)","Angina (Stable)","Microvascular Circulation",[79,80,81,82,83],"angina","coronary artery disease","absolute coronary flow","continuous intracoronary thermodilution","Beta-blockers","2025-07-08",{"date":86,"type":87},"2025-07-14","ACTUAL",{"date":89,"type":87},"2025-07-03",{"date":91,"type":69},"2025-12-31",{"name":5,"class":6},1]