[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566318":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":57,"centralContacts":62,"locations":69,"responsibleParty":90,"collaborators":67,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":67,"eligibilityCriteria":99,"healthyVolunteers":95,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":67,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":117,"whyStopped":67,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Huazhong University of Science and Technology","OTHER",[8,15,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"adductor block+ Bupivacaine liposomes and bupivacaine mixture","EXPERIMENTAL","The patient underwent ultrasound-guided bupivacaine liposome mixture single adductor block during anesthesia induction room for analgesia after total knee arthroplasty .",[13,14],"Drug: Bupivacaine liposome","Procedure: Nerve block mode : adductor block",{"label":16,"type":17,"description":18,"interventionNames":19},"adductor block+ bupivacaine","ACTIVE_COMPARATOR","The patient underwent ultrasound-guided bupivacaine single adductor block during anesthesia induction room for analgesia after total knee arthroplasty",[14,20],"Drug: Bupivacaine",{"label":22,"type":10,"description":23,"interventionNames":24},"femoral triangle block + Bupivacaine liposomes and bupivacaine mixture","The patient underwent ultrasound-guided bupivacaine liposome mixture single femoral triangle block during anesthesia induction room for analgesia after total knee arthroplasty .",[13,25],"Procedure: Nerve block mode: femoral triangle block",{"label":27,"type":17,"description":28,"interventionNames":29},"femoral triangle block + bupivacaine","The patient underwent ultrasound-guided bupivacaine single femoral triangle block during anesthesia induction room for analgesia after total knee arthroplasty .",[20,25],[31,38,45,51],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"DRUG","Bupivacaine liposome","Subjects receive liposomal bupivacaine as a regional anesthetic for femoral triangle block or adductor block under ultrasound guidance.",[9,22],[37],"L",{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"PROCEDURE","Nerve block mode : adductor block","Subjects receive liposomal bupivacaine or bupivacaine as a regional anesthetic for adductor block under ultrasound guidance.",[9,16],[44],"A",{"type":32,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"Bupivacaine","Subjects receive bupivacaine as a regional anesthetic for femoral triangle block or adductor block under ultrasound guidance.",[16,27],[50],"B",{"type":39,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Nerve block mode: femoral triangle block","Subjects receive liposomal bupivacaine or bupivacaine as a regional anesthetic for femoral triangle block under ultrasound guidance.",[22,27],[56],"F",[58],{"name":59,"affiliation":60,"role":61},"wei mei, MD","Tongji Medical College, Huazhong University of Science and Technology","PRINCIPAL_INVESTIGATOR",[63],{"name":64,"role":65,"phone":66,"phoneExt":67,"email":68},"Llingli deng, postgraduate","CONTACT","+86 18707159290",null,"296890303@qq.com",[70],{"facility":71,"status":67,"city":72,"state":73,"zip":74,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":82,"contacts":83},"Lingli DENG","Wuhan","Hubei","430030","China","CN",{"type":78,"coordinates":79},"Point",[80,81],114.26667,30.58333,{"lat":81,"lon":80},[84,86,88],{"name":85,"role":65,"phone":66,"phoneExt":67,"email":68},"lingli DENG, MD",{"name":59,"role":65,"phone":87,"phoneExt":67,"email":68},"+86 13006162508",{"name":89,"role":61,"phone":67,"phoneExt":67,"email":67},"WEI Mei, MD",{"type":61,"investigatorFullName":91,"investigatorTitle":92,"investigatorAffiliation":5,"oldNameTitle":67,"oldOrganization":67},"Wei Mei","clinical professor","100566318","phase-4-effect-of-bupivacaine-liposomes-or-bupivacaine-for-femoral-triangle-or-adductor-block-on-analgesia-after-total-knee-replacement-100566318",false,"NCT06653621","Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement","Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement: a Prospective, Single-center, Simple Randomized, Active-controlled, Single-blind, 2x2 Factorial Design Clinical Study","Inclusion Criteria:\n\n1. Patients with ASAI-ⅲ\n2. Receive a unilateral initial TKA\n3. Age 18-80 years old -\n\nExclusion Criteria:\n\n1. Bilateral TKA surgery\n2. TKA revision surgery\n3. Contraindications for nerve block and intraspinal anesthesia\n4. Allergies to local anesthetics\n5. Diabetic neuropathy\n6. Patients who are unable to cooperate with the evaluation\n7. Chronic use of opioid analgesics\n8. BMI≥35kg\u002Fcm2\n9. Cases of lumbar anesthesia failure requiring general anesthesia surgery\n10. Cases of nerve block failure\n\n    \\-","ALL","18 Years","80 Years",{"count":104,"type":105},144,"ESTIMATED","INTERVENTIONAL",[108],"PHASE4","The purpose of this study was to investigate the effect of bupivacaine liposomes on postoperative pain in TKA ( total knee replacement ) patients.The main questions answered are:\n\n1. Is bupivacaine liposomes superior to bupivacaine in femoral triangle block or adductor block in terms of 72 hours opioid consumption after knee replacement\n2. Which block method(Femoral triangle block or adductor block) combined with bupivacaine liposome was more effective in alleviating pain score and 72 hours opioid consumption after total knee surgery.\n\ninvestigators will investigate the effect of bupivacaine liposomes combined with bupivacaine and pure bupivacaine on pain after total knee arthroplasty using femoral triangle block or adductor block.\n\nParticipants will:\n\n1. Receive liposomal bupivacaine or bupivacaine as a regional anesthetic for femoral triangle block or adductor block under ultrasound guidance.\n2. Undergo total knee replacement surgery under spinal anesthesia.\n3. Follow-up within 72 hours after surgery , opioid consumption, NRS score, PCA（Patient controlled analgesia，PCA） data, first postoperative remedial analgesia time, quadriceps muscle strength and complications were recorded",[111,112],"Knee Arthropathy","Knee Arthritis",[111,114,115,116],"liposome bupivacaine","femoral nerve block","adductor canal block","NOT_YET_RECRUITING","2024-10-22",{"date":120,"type":121},"2024-10-24","ACTUAL",{"date":123,"type":105},"2024-11-05",{"date":125,"type":105},"2025-12-31",{"name":5,"class":6},1]