[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385793":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":50,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":32,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"China Medical University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","PLACEBO_COMPARATOR","All depression patients undergoing breast cancer operation will be to the treatment intervention with general anesthesia as an adjunct to saline.",[13],"Drug: Saline Solution",{"label":15,"type":16,"description":17,"interventionNames":18},"Esketamine","ACTIVE_COMPARATOR","All depression patients undergoing breast cancer operation will be to the treatment intervention with general anesthesia as an adjunct to esketamine.",[19],"Drug: Esketamine",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","All depression patients undergoing breast cancer operation will be to the treatment intervention with general anesthesia as an adjunct to esketamine 0.2mg\u002Fkg.",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Saline Solution",[9],[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"the First Hospital of China Medical University","RECRUITING","Shenyang","Liaoning","110001","China","CN",{"type":39,"coordinates":40},"Point",[41,42],123.43278,41.79222,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":25,"email":49},"Wen-fei Tan, M.D.,Ph.D","CONTACT","024-83283100","winfieldtan@hotmail.com",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Wenfei Tan","Professor","100385793","phase-4-effect-of-esketamine-on-postoperative-depressiongut-microbiotabispectral-index-data-of-depression-patients-undergoing-breast-cancer-operation-espod-bi-100385793",false,"NCT04303325","Effect of Esketamine on Postoperative Depression、Gut Microbiota、Bispectral Index Data of Depression Patients Undergoing Breast Cancer Operation (ESPOD-BI)","ESPOD-BI","Inclusion Criteria:\n\n* At least18 years and pre-menopausal;\n* scheduled to undergo elective breast cancer operation;\n* American Society of Anaesthesiologists (ASA) risk classification I-II.\n* Montgomery-asberg Depression Rating Scale (MADRS) score ≥22\n\nExclusion Criteria:\n\n* Cognitive difficulties\n* Partial or complete gastrectomy\n* Previous esophageal surgery\n* Inability to conform to the study's requirements\n* Ongoing participation or participation in another study \\\u003C1 month ago","FEMALE","18 Years","65 Years",{"count":65,"type":66},72,"ESTIMATED","INTERVENTIONAL",[69],"PHASE4","This study is a prospective, randomized, controlled (randomized, parallel group, concealed allocation), double-blinded trial. All depression patients undergoing breast cancer operation will be randomized 1:1 to the treatment intervention with general anesthesia as an adjunct to esketamine or saline. The objective of the trial is to evaluate the postoperative depression、gut microbiota、bispectral index data of patients undergoing breast cancer operation with esketamine or saline.",[72],"Depression",[74,75,76,77],"depression","sleep deprivation","gut microbiota","bispectral index","2024-07-18",{"date":80,"type":81},"2024-07-22","ACTUAL",{"date":83,"type":81},"2021-10-08",{"date":85,"type":66},"2024-12-30",{"name":5,"class":6},1]