[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628239":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":30,"locations":36,"responsibleParty":56,"collaborators":11,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":11,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":11,"enrollmentInfo":68,"targetDuration":11,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":39,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Baghdad","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group: Undergo Conventional Non-Surgical Periodontal Therapy and not receiving Ibuprofen","ACTIVE_COMPARATOR",null,[13],"Procedure: Non surgical root surface debridement in one stage without receiving Ibuprofen",{"label":15,"type":16,"description":11,"interventionNames":17},"Test group: Undergo Conventional Non-Surgical Periodontal Therapy and receiving Ibuprofen","EXPERIMENTAL",[18],"Drug: Non surgical root surface debridement in one stage with receiving Ibuprofen",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Non surgical root surface debridement in one stage without receiving Ibuprofen","Control group: After one week from baseline visit which include supragingival debridement by using ultrasonic device . sites will receive root surface debridement (RSD) using area specific (Gracey) curettes (Medesy, Italy). Without receiving Ibuprofen.",[9],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"DRUG","Non surgical root surface debridement in one stage with receiving Ibuprofen","Test group: After one week from baseline visit which include supragingival debridement by using ultrasonic device . Test group will receive first dose of Ibuprofen (400 mg) administer one hour before root surface debridement and the subsequent doses will be taken 3 times daily for a duration of 3 days after RSD.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":11,"email":35},"Nabaa Ismail Ibrahim, B.D.S","CONTACT","009647740580458","naba.ismail2405@codental.uobaghdad.edu.iq",[37],{"facility":38,"status":39,"city":40,"state":11,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"College of Dentistry, University of Baghdad","RECRUITING","Baghdad","10047","Iraq","IQ",{"type":45,"coordinates":46},"Point",[47,48],44.40088,33.34058,{"lat":48,"lon":47},[51,54],{"name":38,"role":33,"phone":52,"phoneExt":11,"email":53},"0096414169394","master@codental.uobaghdad.edu.iq",{"name":32,"role":55,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"type":55,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Nabaa Ismail Ibrahim","Principal Investigator","100628239","phase-4-effect-of-ibuprofen-on-acute-inflammatory-response-after-one-stage-periodontal-therapy-100628239",false,"NCT07459049","\"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy\"","Efficacy Of Ibuprofen In Reducing Acute Inflammatory Response Following One Stage Non- Surgical Periodontal Therapy (A Randomized Clinical Trial )","Inclusion Criteria:\n\n1. systemically healthy patients.\n2. having a minimum of 20 teeth.\n3. Generalized unstable periodontitis.\n4. Pocket depth \\[≥ 4 mm\\].\n5. All included participants should be adults aged more than 18 years .\n6. smokers and non smokers\n\nExclusion Criteria:\n\n1. Allergy or hypersensitivity to Ibuprofen or other NSAIDs.\n2. current systemic anti-inflammatory or antibiotic therapy (\\\u003C3 months).\n3. peptic ulcer disease.\n4. recent periodontal therapy (\\\u003C3 months).\n5. Asthma.\n6. Renal impairment .\n7. Hepatic impairment.\n8. Severe cardiac disease (heart failure, hypertension (.\n9. Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .\n10. Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.\n11. pregnant or lactating females.\n12. those being unable to provide written informed consent.","ALL","18 Years",{"count":69,"type":70},30,"ESTIMATED","INTERVENTIONAL",[73],"PHASE4","The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy.\n\nThe main question it aims to answer is:\n\n\"Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?\"",[76],"Periodontitis",[78,79,80,81],"Ibuprofen","Acute inflammatory response","One stage periodontal therapy","Non-surgical periodontal therapy","2026-03-06",{"date":84,"type":85},"2026-03-09","ACTUAL",{"date":87,"type":85},"2025-12-01",{"date":89,"type":70},"2026-08",{"name":5,"class":6},1]