[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632357":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":45,"responsibleParty":64,"collaborators":43,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":43,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":43,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":48,"whyStopped":43,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Sanming First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","ACTIVE_COMPARATOR","30 mL of 0.25% bupivacaine hydrochloride was administered by the surgeon under thoracoscopy to perform intercostal nerve block at the 3rd to 8th intercostal spaces, with 5 mL injected into each intercostal space prior to the start of the procedure.",[13],"Drug: Bupivacaine Hydrochloride",{"label":15,"type":16,"description":17,"interventionNames":18},"Liposome bupivacaine group","EXPERIMENTAL","A 30 mL solution was prepared by diluting 15 mL of bupivacaine liposome with 15 mL of 0.9% sodium chloride. Prior to the procedure, the surgeon performed intercostal nerve blockage at the 3rd to 8th intercostal spaces under thoracoscopy, injecting 5 mL into each intercostal space.",[19],"Drug: Bupivacaine liposome",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Bupivacaine Hydrochloride","Single-dose, pre-procedural intercostal nerve block with bupivacaine hydrochloride, administered by thoracoscopy prior to surgery.",[9],[27],"Marcaine, Sensorcaine",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Bupivacaine liposome","Single-dose, pre-procedural intercostal nerve block with bupivacaine liposome, administered by thoracoscopy prior to surgery.",[15],[33],"Exparel, liposomal bupivacaine",[35],{"name":36,"affiliation":37,"role":38},"Huifen Lin, MD","No. 15, Liedong Street, Sanyuan District, Sanming City, Fujian Province","PRINCIPAL_INVESTIGATOR",[40],{"name":36,"role":41,"phone":42,"phoneExt":43,"email":44},"CONTACT","（0598）8803263",null,"smyhb0598@163.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":43,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"SanMing First Hospital","RECRUITING","Sanming","Fujian","China","CN",{"type":54,"coordinates":55},"Point",[56,57],117.61861,26.24861,{"lat":57,"lon":56},[60],{"name":61,"role":41,"phone":62,"phoneExt":43,"email":63},"Huifen Lin, PHD","0591-5183881","306246774@qq.com",{"type":38,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Lin Huifen","Associate Professor of Anesthesiology","100632357","phase-4-effect-of-intercostal-nerve-block-with-liposomal-bupivacaine-on-quality-of-recovery-in-vats-partial-pneumonectomy-100632357",false,"NCT07512635","Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Quality of Recovery in VATS Partial Pneumonectomy","Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Postoperative Quality of Recovery in Patients Undergoing Video-assisted Thoracoscopic Partial Pneumonectomy","Inclusion Criteria:\n\n* Patients scheduled for thoracic surgery under general anesthesia via thoracoscopic approach;\n* Age 18-65 years;\n* Classified as Grade I-II by the American Society of Anesthesiologists (ASA).\n\nExclusion Criteria:\n\n* History of local anesthetic allergy.\n* Chronic opioid users.\n* Contraindications for nerve block, including infection at the puncture site and coagulation disorders;\n* Language communication impairment.\n* Other conditions unsuitable for inclusion in the trial.","ALL","18 Years","65 Years",{"count":78,"type":79},96,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","Video-assisted thoracoscopic surgery (VATS) is a minimally invasive approach for partial pneumonectomy, but postoperative pain remains a major challenge affecting recovery. Intercostal nerve block (ICNB) with conventional local anesthetics provides limited duration of analgesia, often insufficient to cover the peak pain period after surgery. Liposomal bupivacaine is a long-acting formulation designed to provide extended analgesia up to 72 hours. This study aims to evaluate the effect of preoperative ICNB with liposomal bupivacaine compared with conventional bupivacaine hydrochloride on postoperative quality of recovery in patients undergoing VATS partial pneumonectomy. The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours postoperatively. We hypothesize that liposomal bupivacaine ICNB results in superior recovery quality compared with conventional bupivacaine, with reduced postoperative pain and opioid consumption.",[85,86],"Pulmonary Nodule","Liposomal Bupivacaine",[88,89],"Liposomal bupivacaine","Intercostal nerve block","2026-06-17",{"date":92,"type":93},"2026-06-18","ACTUAL",{"date":95,"type":93},"2026-04-06",{"date":97,"type":79},"2027-04-30",{"name":5,"class":6},1]