[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100434562":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":61,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":41,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Loma Linda University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Magnesium sulfate arm","EXPERIMENTAL","MgSo4 diluted to 20% will be administered at 40 mg\u002Fkg dosed to ideal body weight over 10min to the study arm followed by 10mg\u002Fkg\u002Fhr infusion.",[13],"Drug: Magnesium sulfate",{"label":15,"type":16,"description":17,"interventionNames":18},"Normal Saline","PLACEBO_COMPARATOR","20 ml of normal saline bolus will be administered to the control group over 10 mins.",[19],"Drug: Normal Saline",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Magnesium sulfate","Effect of 40mg\u002Fkg Magnesium sulfate bolus dosed to ideal body weight on intraoperative neuromonitoring",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":28,"otherNames":26},[15],[30],{"name":31,"affiliation":5,"role":32},"Rashmi Vandse, MD","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":26,"email":37},"CONTACT","9095584000","rvandse@llu.edu",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Loma linda University Medical Center","RECRUITING","Loma Linda","California","92354","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-117.26115,34.04835,{"lat":51,"lon":50},[54,57],{"name":31,"role":35,"phone":55,"phoneExt":56,"email":37},"909-558-4000","88054",{"name":58,"role":35,"phone":59,"phoneExt":26,"email":60},"Penelope Garcia","909.558.5966","pegarcia@llu.edu",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100434562","phase-4-effect-of-magnesium-sulfate-bolus-on-intraoperative-neuromonitoring-100434562",false,"NCT04938765","Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring","Randomized and Placebo Controlled Study to Evaluate the Effect of Magnesium Sulfate on Intraoperative Neuromonitoring.","Inclusion Criteria.\n\n* Patients aged 18 to 80 years\n* Belonging to American Society of Anesthesiologists physical status (ASA) I, II\n* Undergoing elective spine or cranial surgery where intraoperative neuromonitoring including short latency somatosensory evoked potentials (SSEP or SEP) and transcranial electrical muscle motor evoked potentials recording from muscles (TceMEP or TcMEP or mMEP or MEP) is planned.\n\nExclusion Criteria:\n\n* Magnesium use within the last 2 days, either intravenous or oral supplements.\n* Patients with known electrolyte imbalances (Sodium \\\u003C135 or \\>145 mmol\u002FL OR Potassium \\\u003C 3.5 or \\> 5.0 mmol\u002FL, Magnesium \\>1.2 mmol\u002FL.\n* Severe cardiac or cardiac conduction disorders.\n* Severe pulmonary disease.\n* Patients with significant neuromuscular disorders or preexisting motor or sensory deficits other than focal upper limb neuropathy or focal cervical radiculopathy or mild cervical myelopathy.\n* Severe Renal disease - serum creatinine of \\> 2 mg\u002Fdl.\n* Pregnant or breastfeeding patients.\n* Unable to obtain adequate baseline SSEPs and MEPs.","ALL","18 Years","80 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to assess the functional integrity of the neural pathways. The effect of Magnesium sulfate on IONM has not been studied.\n\nThis is a prospective, double blind, randomized placebo controlled trial to study the effect of Magnesium sulfate bolus on the amplitude and latency of somatosensory(SSEPs) and motor evoked potentials(MEPs) in patients undergoing surgery requiring IONM.",[81,82],"Intraoperative Neurophysiological Monitoring","Magnesium Sulfate",[84],"multimodal analgesia","2026-04-21",{"date":87,"type":88},"2026-04-24","ACTUAL",{"date":90,"type":88},"2022-03-18",{"date":92,"type":75},"2027-03",{"name":5,"class":6},1]