[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626415":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Rawalpindi Institute of Cardiology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group Nalbuphine","ACTIVE_COMPARATOR","Participants will receive an injection of nalbuphine 0.2 mg\u002Fkg intravenous slowly over 5 minutes before induction.",[13],"Drug: Nalbuphine",{"label":15,"type":10,"description":16,"interventionNames":17},"Group Fentanyl","Participants will receive an injection of fentanyl 3 µg\u002Fkg intravenous slowly over 5 min before induction.",[18],"Drug: Fentanyl",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Nalbuphine","IV Nalbuphine at dose of 0.2 mg\u002Fkg will be given 5 minutes before induction of anesthesia",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Fentanyl","3 Microgram per kilogram body weight IV Fentanyl will be given 5 minutes before induction of anesthesia",[15],[31],{"name":32,"affiliation":33,"role":34},"Qudsia Qureshi, MBBS","Head of Department of Anesthesia","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Ayemon Principal Investigator, MBBS","CONTACT","+923211579066","ayemonfatima@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Deparment of Anesthesia, Rawalpindi Institute of Cardiology, Rawalpindi","RECRUITING","Rawalpindi","Punjab Province","46000","Pakistan","PK",{"type":51,"coordinates":52},"Point",[53,54],73.0479,33.59733,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":25,"email":40},"Ayemon Fatima Principal Investigator, MBBS","+92 321 1579066",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Dr Ayemon Fatima","Principal Investigator","100626415","phase-4-effect-of-nalbuphine-versus-fentanyl-on-hemdoynamic-effects-of-laryngoscopy-100626415",false,"NCT07435337","Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy","COMPARISON OF HEMODYNAMIC EFFECTS OF NALBUPHINE VERSUS FENTANYL: A RANDOMIZED, DOUBLE-BLINDED INTERVENTIONAL STUDY IN PATIENTS ON CARDIOPULMONARY BYPASS AT RAWALPINDI INSTITUTE OF CARDIOLOGY, RAWALPINDI","Inclusion Criteria:\n\n* Weighing 40-70kg\n\n  * ASA III of either sex\n  * Undergoing cardiac surgery with CPB\n\nExclusion Criteria:\n\n• History of Drug Allergy • Pre-existing Asthma • Renal or Hepatic dysfunction • Extreme obesity • Pregnant \u002F lactating patients • Difficult intubation\u002Fprolonged intubation",true,"ALL","40 Years","60 Years",{"count":76,"type":77},98,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG, breathing monitor, and temperature) will be applied. A central venous catheter and an arterial line will be inserted under local anesthesia using sterile technique.\n\nBefore anesthesia induction, patients will receive premedication including midazolam and an opioid pain-relief injection given slowly through the vein. General anesthesia will then be induced with etomidate. After adequate sedation, a muscle relaxant (atracurium) will be administered, and the patient will be ventilated with 100% oxygen using a face mask. The breathing tube will then be inserted and correct placement confirmed.\n\nDuring surgery, anesthesia will be maintained with oxygen, sevoflurane gas, and a continuous atracurium infusion. Hemodynamic parameters such as heart rate and blood pressure will be monitored throughout the peri-intubation and intraoperative period.",[83,84],"Laryngoscopy","Hemodynamic Changes",[86],"Laryngoscopic stress response","2026-02-20",{"date":89,"type":90},"2026-02-27","ACTUAL",{"date":92,"type":90},"2026-02-21",{"date":94,"type":77},"2026-05-21",{"name":5,"class":6},1]