[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549027":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":12,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":12,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":12,"enrollmentInfo":66,"targetDuration":12,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":39,"whyStopped":12,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"No nitropaste group","NO_INTERVENTION","Participants get standard of care chest masculinizing surgery utilizing double incision and free nipple grafting surgery. They will get standard dressing applied, which includes Xeroform bolster over the nipple grafts + Tegederm over the bolster and surgical site and instructed not to remove the dressing until they come to clinic on POD5 for bolster take down.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Nitropaste group","EXPERIMENTAL","Participants get standard of care chest masculinizing surgery utilizing double incision and free nipple grafting surgery. They will then get 2 packets of nitropaste applied (1 on each chest) around the free nipple graft and surgical sites. They will then get standard dressing applied, which includes Xeroform bolster over the nipple grafts + Tegederm over the bolster and surgical site and instructed not to remove the dressing until they come to clinic on POD5 for bolster take down.",[18],"Drug: Nitro-Bid 2 % Topical Ointment",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DRUG","Nitro-Bid 2 % Topical Ointment","Intervention group will get 30mg of Nitro-Bid topical ointment applied over the chest (15mg\u002F 1 packet on each side) one time intra-operatively",[14],[26],{"name":27,"affiliation":28,"role":29},"John T Stranix, MD","UVA","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":12,"email":35},"Rachel H Park, MD","CONTACT","434-327-2140","rhp7gu@hscmail.mcc.virginia.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University of Virginia Medical Center","RECRUITING","Charlottesville","Virginia","22902","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-78.47668,38.02931,{"lat":49,"lon":48},[52],{"name":32,"role":33,"phone":53,"phoneExt":12,"email":35},"571-428-7278",{"type":29,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"John Stranix","Assistant Professor, Department of Plastic Surgery","100549027","phase-4-effect-of-nitropaste-in-chest-masculinizing-surgery-100549027",false,"NCT06428669","Effect of Nitropaste in Chest Masculinizing Surgery","The Effect of Nitropaste in Chest Masculinizing Surgery: Randomized, Prospective Trial","Inclusion Criteria:\n\n* Any adult (18 or older) patients of any gender identity who are undergoing chest masculinizing surgery with double incision and free nipple grafting.\n\nExclusion Criteria:\n\n* Minor patients (younger than 18)\n* Anyone who's not getting free nipple grafting\n* Anyone who's not utilizing double incision pattern\n* Prisoners, anyone who is allergic to nitropaste\n* Anyone who is taking phosphodiesterase inhibitor (ex)Sildenafil, tadalafil, vardenafil)\n* Anyone who's taking soluble guanylate cyclase stimulator riociguatdz","FEMALE","18 Years",{"count":67,"type":68},256,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","Nitropaste is a topical agent that contains 2% nitroglycerin. It is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature. While its main indication is for angina pectoris, there have been many studies showing improved survival of axial and random pattern flaps. Furthermore, recent clinical studies highlight significantly decreased mastectomy flap wound complication and need for sharp debridement. Nitropaste has low rates of side effects and is very well tolerated in general. To this date, there's no study that investigates its utility on patients who are undergoing chest masculinizing surgery. The purpose of this study is to investigate the potential utility of nitropaste in reducing rates of wound complications in patients undergoing chest masculinizing surgery.",[74],"Gender Dysphoria",[76,77,78,79],"Gender affirming surgery","Chest masculinizing Surgery","Nitropaste","Wound healing","2024-06-03",{"date":82,"type":83},"2024-06-06","ACTUAL",{"date":85,"type":83},"2022-08-15",{"date":87,"type":68},"2025-11",{"name":5,"class":6},1]